{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T01:45:29Z","timestamp":1788140729492,"version":"build-2803163510"},"reference-count":70,"publisher":"Informa UK Limited","issue":"13","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201400006I"],"award-info":[{"award-number":["HHSN272201400006I"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health","award":["R01AI147731-01A1, R15NS108815-01"],"award-info":[{"award-number":["R01AI147731-01A1, R15NS108815-01"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine (Lond.)"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.2217\/nnm-2022-0043","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T04:42:50Z","timestamp":1654058570000},"page":"959-978","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":18,"title":["Effect of Drug-To-Lipid Ratio on Nanodisc-Based Tenofovir Drug Delivery to The Brain for HIV-1 Infection"],"prefix":"10.1080","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8292-8341","authenticated-orcid":false,"given":"Caroline R","family":"Garcia","sequence":"first","affiliation":[{"name":"Department of Health & Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4223-4393","authenticated-orcid":false,"given":"Armin T","family":"Rad","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA"},{"name":"Polymer Program, Institute of Materials Sciences, University of Connecticut, Storrs, CT 06269, USA"},{"name":"Encapsulate, University of Connecticut Technology Incubation Program, Farmington, CT 06032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0666-9066","authenticated-orcid":false,"given":"Farnoosh","family":"Saeedinejad","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA"},{"name":"Polymer Program, Institute of Materials Sciences, University of Connecticut, Storrs, CT 06269, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Manojkumar","sequence":"additional","affiliation":[{"name":"Department of Health & Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Health & Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansapani","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Department of Mathematical & Statistical Sciences, University of Texas Rio Grande Valley, Edinburg, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0153-6213","authenticated-orcid":false,"given":"Sue Anne","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Health & Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0402-825X","authenticated-orcid":false,"given":"Ziyaur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Texas A&M University, College Station, TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4462-8716","authenticated-orcid":false,"given":"Mu-Ping","family":"Nieh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA"},{"name":"Polymer Program, Institute of Materials Sciences, University of Connecticut, Storrs, CT 06269, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0325-567X","authenticated-orcid":false,"given":"Upal","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Health & Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3132"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425240903081705"},{"key":"e_1_3_5_5_1","unstructured":"UNAIDS. 90-90-90: an ambitious treatment target to help end the AIDS epidemic (2014). www.unaids.org\/sites\/default\/files\/media_asset\/90-90-90_en.pdf"},{"key":"e_1_3_5_6_1","unstructured":"UNAIDS. Ending AIDS: progress towards the 90-90-90 targets (2017). www.unaids.org\/en\/resources\/documents\/2017\/20170720_Global_AIDS_update_2017"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-019-09886-7"},{"issue":"4","key":"e_1_3_5_8_1","first-page":"1113","article-title":"HIV-associated neurocognitive disorder (HAND) and the prospect of brain-penetrating protease inhibitors for antiretroviral treatment","volume":"5","author":"Ghosh AK","year":"2017","unstructured":"Ghosh AK, Sarkar A, Mitsuya H. HIV-associated neurocognitive disorder (HAND) and the prospect of brain-penetrating protease inhibitors for antiretroviral treatment. Med. Res. Arch. 5(4), 1113 (2017).","journal-title":"Med. Res. Arch."},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0392-8"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2013.06.012"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.02.007"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1632"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj070"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1409"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/23080477.2016.1255293"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(02)00347-2"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2992"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-015-5519-y"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305000110"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl052396o"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2014.950564"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm5017805"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.584253"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500827"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201804227"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.09.013"},{"issue":"16","key":"e_1_3_5_28_1","first-page":"4440","article-title":"Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size","volume":"60","author":"Kong G","year":"2000","unstructured":"Kong G, Braun RD, Dewhirst MW. Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size. Cancer Res. 60(16), 4440\u20134445 (2000).","journal-title":"Cancer Res."},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10404-012-1024-5"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801763105"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.06.051"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S68861"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.15464"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2012.637916"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/22\/19\/195102"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(09)65001-1"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2016.2292"},{"key":"e_1_3_5_38_1","first-page":"273","article-title":"Stable discoidal bicelles: a platform of lipid nanocarriers for cellular delivery","volume":"1522","author":"Liu Y","year":"2017","unstructured":"Liu Y, Xia Y, Rad AT, Aresh W, Nieh MP. Stable discoidal bicelles: a platform of lipid nanocarriers for cellular delivery. Methods Protoc. 1522, 273\u2013282 (2017).","journal-title":"Methods Protoc."},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/la2023314"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/la0508994"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b21609"},{"key":"e_1_3_5_42_1","unstructured":"World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach. (2016)."},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2014.02.004"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202100080"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR03667A"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202009750"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.02.017"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016024005429"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0013178"},{"key":"e_1_3_5_50_1","first-page":"030049","volume-title":"AIP Conference Proceedings.","author":"DiFabio J","year":"2016","unstructured":"DiFabio J, Chodankar S, Pjerov S et al. The life science x-ray scattering beamline at NSLS-II. AIP Conference Proceedings. AIP Publishing LLC, NY USA, 030049 (2016)."},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0909049512048984"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16703-9"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.15.160"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075374"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S27830"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.09.71"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S68348"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.16.1"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2013.07.019"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002858"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.08.022"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12111057"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S55805"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.34172\/apb.2020.021"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2016.1153568"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-018-2728-6"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.12.013"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare8040417"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.12.022"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.2147\/CPAA.S119875"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz187"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2018.07.003"}],"container-title":["Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/nnm-2022-0043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:50:11Z","timestamp":1716479411000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/nnm-2022-0043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":70,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.2217\/nnm-2022-0043"],"URL":"https:\/\/doi.org\/10.2217\/nnm-2022-0043","relation":{},"ISSN":["1743-5889","1748-6963"],"issn-type":[{"value":"1743-5889","type":"print"},{"value":"1748-6963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}