{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T09:05:18Z","timestamp":1782119118114,"version":"3.54.5"},"reference-count":83,"publisher":"Informa UK Limited","issue":"20","funder":[{"name":"Shaanxi Social Development Fund","award":["2020SF-067"],"award-info":[{"award-number":["2020SF-067"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine (Lond.)"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.2217\/nnm-2022-0083","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T10:09:59Z","timestamp":1667470199000},"page":"1411-1427","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":15,"title":["Targeted Activation of\n            <i>HNF4\u03b1\/HGF1\/FOXA2<\/i>\n            Reverses Hepatic Fibrosis Via Exosome-Mediated Delivery of CRISPR\/dCas9-SAM System"],"prefix":"10.1080","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8642-0238","authenticated-orcid":false,"given":"Nianan","family":"Luo","sequence":"first","affiliation":[{"name":"Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, 710038, China"},{"name":"Department of General Surgery, 943 Hospital of PLA, Wuwei, 733000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, 710038, China"},{"name":"School of Clinical Medicine, Xi\u2019an Medical University, Xi\u2019an, 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, 710038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjie","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Military Preventive Medicine, Fourth Military Medical University, Xi\u2019an, 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, 710038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, 710038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31418"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00372-7"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.02.026"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2018.09.002"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31771"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01374-X"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32285"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.008"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0342-4"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00373-7"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.026"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32209"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.04.014"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.38"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.10.026"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0511-2"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-306842"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31987"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.012"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31752"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00176"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14961"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31875"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00165"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00513"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-020-00371-5"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2019-0104"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.02.005"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47007"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1197"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.06.003"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-01071-7"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2020.10.019"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac049"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.02.005"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.02.023"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.023"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.02.003"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.01.014"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.114042"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.12.053"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2022.05.003"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114450"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-021-10217-3"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114487"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01305-4"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.52570"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.06.014"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.08.011"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221085"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15831-6"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.8b00192"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR07622H"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31995"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108117"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31457"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.05.027"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.07.004"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58739-4"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00754-w"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317872"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02346-4"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2019.1642067"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.05.001"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.05.022"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119375"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03036"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1850917"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.04.006"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-07639-9"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1706910"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000678R"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.10.018"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.03.009"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2020.12.005"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b02689"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2020.1816710"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201902686"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00427H"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.021"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715965115"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.05.032"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14136"}],"container-title":["Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/nnm-2022-0083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:49:34Z","timestamp":1716493774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/nnm-2022-0083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":83,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.2217\/nnm-2022-0083"],"URL":"https:\/\/doi.org\/10.2217\/nnm-2022-0083","relation":{},"ISSN":["1743-5889","1748-6963"],"issn-type":[{"value":"1743-5889","type":"print"},{"value":"1748-6963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}