{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:25:55Z","timestamp":1771637155977,"version":"3.50.1"},"reference-count":50,"publisher":"Informa UK Limited","issue":"30","funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"crossref","award":["ZR2019MH098, ZR2020MH408"],"award-info":[{"award-number":["ZR2019MH098, ZR2020MH408"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine (Lond.)"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.2217\/nnm-2022-0208","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T09:56:32Z","timestamp":1679046992000},"page":"2215-2229","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":6,"title":["5-Fluorouracil-Caffeic Acid Cocrystal Delivery Agent with Long-Term and Synergistic High-Performance Antitumor Effects"],"prefix":"10.1080","volume":"17","author":[{"given":"Yue-Ming","family":"Yu","sequence":"first","affiliation":[{"name":"School of Medicine &amp; Pharmacy &amp; College of Marine Life Science, Ocean University of China, Qingdao, Shandong, 266003, China"},{"name":"Laboratory for Marine Drugs &amp; Bioproducts, Qingdao National Laboratory for Marine Science &amp; Technology, Shandong, 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan-Zhi","family":"Bu","sequence":"additional","affiliation":[{"name":"School of Medicine &amp; Pharmacy &amp; College of Marine Life Science, Ocean University of China, Qingdao, Shandong, 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yu","sequence":"additional","affiliation":[{"name":"Qingdao Institute for Food &amp; Drug Control, Qingdao, Shandong, 266071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui-Wei","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Medicine &amp; Pharmacy &amp; College of Marine Life Science, Ocean University of China, Qingdao, Shandong, 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yong","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine &amp; Pharmacy &amp; College of Marine Life Science, Ocean University of China, Qingdao, Shandong, 266003, China"},{"name":"Laboratory for Marine Drugs &amp; Bioproducts, Qingdao National Laboratory for Marine Science &amp; Technology, Shandong, 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7475-5591","authenticated-orcid":false,"given":"Yan-Tuan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine &amp; Pharmacy &amp; College of Marine Life Science, Ocean University of China, Qingdao, Shandong, 266003, China"},{"name":"Laboratory for Marine Drugs &amp; Bioproducts, Qingdao National Laboratory for Marine Science &amp; Technology, Shandong, 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/0889311X.2021.1978079"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200720114638"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.2c00052"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.1c00022"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2020.01.021"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CE00407G"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2021.08.015"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201002588"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13020127"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2017.11.014"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2012.08.005"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.107447"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jced.8b00425"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-020-01672-6"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2008.00280.x"},{"issue":"1","key":"e_1_3_5_19_1","first-page":"728","article-title":"Synergistic effect of kaempferol and 5 fluorouracil on the growth of colorectal cancer cells by regulating the PI3K\/Akt signaling pathway","volume":"20","author":"Li Q","year":"2019","unstructured":"Li Q , WeiL, LinS, ChenY, LinJ, PengJ. Synergistic effect of kaempferol and 5 fluorouracil on the growth of colorectal cancer cells by regulating the PI3K\/Akt signaling pathway. Mol. Med. Rep.20(1), 728\u2013734 (2019).","journal-title":"Mol. Med. Rep."},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA03105B"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2014.04.062"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cryst8020101"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CE01297A"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2019.e00370"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105759"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c03009"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2009.08.006"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.1c01143"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.105883"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.9b00591"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2012.02.110"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1119\/1.19375"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.22885"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3382344"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/00268977000101561"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2009.12.007"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2016.01.012"},{"issue":"11","key":"e_1_3_5_38_1","first-page":"1","article-title":"Thermal analysis, structure, spectroscopy and DFT calculations of a pharmaceutical cocrystal of salicylic acid and salicylamide","volume":"138","author":"Phetmung H","year":"2019","unstructured":"Phetmung H , MusikapongK, SrichanaT. Thermal analysis, structure, spectroscopy and DFT calculations of a pharmaceutical cocrystal of salicylic acid and salicylamide. J. Therm. Anal. Calorim.138(11), 1\u201314 (2019).","journal-title":"J. Therm. Anal. Calorim."},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.130215"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00324-4"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja954283k"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CE02089E"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2022.106241"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2009.08.032"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2nr30924f"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1878-3317(10)60002-2"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00396-004-1243-8"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S33607"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9451-9"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.05.053"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1295\/polymj.PJ2006172"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.05.059"}],"container-title":["Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/nnm-2022-0208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:49:39Z","timestamp":1716493779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/nnm-2022-0208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":50,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.2217\/nnm-2022-0208"],"URL":"https:\/\/doi.org\/10.2217\/nnm-2022-0208","relation":{},"ISSN":["1743-5889","1748-6963"],"issn-type":[{"value":"1743-5889","type":"print"},{"value":"1748-6963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}