{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:04:01Z","timestamp":1780671841807,"version":"3.54.1"},"reference-count":66,"publisher":"Informa UK Limited","issue":"4","funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/25905-2, 2020\/01441-4"],"award-info":[{"award-number":["2019\/25905-2, 2020\/01441-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine (Lond.)"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.2217\/nnm-2022-0228","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T13:28:30Z","timestamp":1683206910000},"page":"331-342","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":6,"title":["Enhancing The Antischistosomal Activity of Carvacryl Acetate Using Nanoemulsion"],"prefix":"10.1080","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5466-4932","authenticated-orcid":false,"given":"Rafael L","family":"de Souza","sequence":"first","affiliation":[{"name":"Laboratory of Synthesis & Drug Delivery, State University of Para\u00edba, Jo\u00e3o Pessoa, 58071-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-425X","authenticated-orcid":false,"given":"Ana C","family":"Mengarda","sequence":"additional","affiliation":[{"name":"Research Center for Neglected Diseases, Guarulhos University, Guarulhos, 07023-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2625-8811","authenticated-orcid":false,"given":"Daniel B","family":"Roquini","sequence":"additional","affiliation":[{"name":"Research Center for Neglected Diseases, Guarulhos University, Guarulhos, 07023-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7256-8891","authenticated-orcid":false,"given":"Camila O","family":"Melo","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis & Drug Delivery, State University of Para\u00edba, Jo\u00e3o Pessoa, 58071-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5967-9554","authenticated-orcid":false,"given":"Mayara C","family":"de Morais","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa, 58051-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"C Esp\u00edrito-Santo","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology of Schistosomiasis (LIM-06), Department of Infectious & Parasitic Diseases, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, 01246903, Brazil"},{"name":"Laboratory of Helminthology, Institute of Tropical Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-4896","authenticated-orcid":false,"given":"Dami\u00e3o P","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa, 58051-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-7031","authenticated-orcid":false,"given":"Josu\u00e9 de","family":"Moraes","sequence":"additional","affiliation":[{"name":"Research Center for Neglected Diseases, Guarulhos University, Guarulhos, 07023-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7214-4455","authenticated-orcid":false,"given":"Elquio E","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis & Drug Delivery, State University of Para\u00edba, Jo\u00e3o Pessoa, 58071-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.635869"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812165"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0013-8"},{"key":"e_1_3_5_6_1","unstructured":"WHO . Schistosomiasis (2022). www.who.int\/news-room\/fact-sheets\/detail\/schistosomiasis"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2019.06.001"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-018-0448-x"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2021.106048"},{"issue":"4","key":"e_1_3_5_10_1","first-page":"1","article-title":"Artemether and praziquantel: origin, mode of action, impact, and suggested application for effective control of human schistosomiasis","volume":"3","author":"Bergquist R","year":"2018","unstructured":"Bergquist R , ElmorshedyH. Artemether and praziquantel: origin, mode of action, impact, and suggested application for effective control of human schistosomiasis. Trop. Med. Infect. Dis.3(4), 1\u201313 (2018).","journal-title":"Trop. Med. Infect. Dis."},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00542"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2006.74.342"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000504"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2014.09.006"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2022.2051477"},{"key":"e_1_3_5_16_1","unstructured":"WHO . Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021\u20132030. Geneva. www.who.int\/publications\/i\/item\/9789240010352 (2020)."},{"issue":"4","key":"e_1_3_5_17_1","first-page":"383","article-title":"Carvacryl acetate nanoencapsulated with chitosan\/chich\u00e1 gum exhibits reduced toxicity in mice and decreases the fecal egg count of sheep infected with gastrointestinal nematodes","volume":"19","author":"Andr\u00e9 WPP","year":"2021","unstructured":"Andr\u00e9 WPP , JuniorJRP, CavalcanteGSet al. Carvacryl acetate nanoencapsulated with chitosan\/chich\u00e1 gum exhibits reduced toxicity in mice and decreases the fecal egg count of sheep infected with gastrointestinal nematodes. Parasitology19(4), 383\u2013393 (2021).","journal-title":"Parasitology"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1984-29612019098"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2016.01.001"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-012-3172-7"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-021-07333-2"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2020.101081"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.afnr.2016.12.008"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2016.11.061"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2018.11.024"},{"key":"e_1_3_5_26_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2022.917363","article-title":"Therapeutic efficacy of carvacrol-loaded nanoemulsion in a mouse model of schistosomiasis","volume":"13","author":"Xavier ES","year":"2022","unstructured":"Xavier ES , de SouzaRL, RodriguesVCet al. Therapeutic efficacy of carvacrol-loaded nanoemulsion in a mouse model of schistosomiasis. Front. Pharmacol.13(June), 1\u20139 (2022).","journal-title":"Front. Pharmacol."},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/lam.13411"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26133899"},{"issue":"4","key":"e_1_3_5_29_1","first-page":"375","article-title":"Synthesis and in vitro antibacterial activity of new oxoethylthio-1,3,4-oxadiazole derivatives","volume":"67","author":"Mathela CS","year":"2010","unstructured":"Mathela CS , SinghKK, GuptaV. Synthesis and in vitro antibacterial activity of new oxoethylthio-1,3,4-oxadiazole derivatives. Acta Pol. Pharm. Drug Res.67(4), 375\u2013380 (2010).","journal-title":"Acta Pol. Pharm. Drug Res."},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/21691401.2014.887018"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.04.029"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01372-20"},{"key":"e_1_3_5_33_1","first-page":"7","article-title":"Flavonoids and sesquiterpene lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni worms","volume":"2016","author":"De Almeida LMS","year":"2016","unstructured":"De Almeida LMS , DeCarvalho LSA, GazollaMCet al. Flavonoids and sesquiterpene lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni worms. Evid. Based Complement. Altern. Med.2016, 7\u20139 (2016).","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2018.02.012"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c01050"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.901459"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-23110-2"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01722-18"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01208-19"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196667"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14070686"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7184"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2020.105371"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02792-0"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.energyfuels.8b00043"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2017-0112"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-019-3563-z"},{"issue":"9","key":"e_1_3_5_48_1","first-page":"1151","article-title":"Reduced efficacy of praziquantel against Schistosoma mansoni is associated with multiple rounds of mass drug administration","volume":"63","author":"Crellen T","year":"2016","unstructured":"Crellen T , WalkerM, LambertonPHLet al. Reduced efficacy of praziquantel against Schistosoma mansoni is associated with multiple rounds of mass drug administration. Clin. Infect. Dis.63(9), 1151\u20131159 (2016).","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1958-7"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.04.004"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87642-9"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SM02958A"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.01.043"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.11.016"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.03.006"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141788"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.12.022"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b04916"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.017"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S167285"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2021.108142"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105018"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2020-0311"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30977-6"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2020.105741"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-020-04140-z"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2021-0146"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2017-0308"}],"container-title":["Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/nnm-2022-0228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:49:43Z","timestamp":1716493783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/nnm-2022-0228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.2217\/nnm-2022-0228"],"URL":"https:\/\/doi.org\/10.2217\/nnm-2022-0228","relation":{},"ISSN":["1743-5889","1748-6963"],"issn-type":[{"value":"1743-5889","type":"print"},{"value":"1748-6963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}