{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:07:50Z","timestamp":1792508870985,"version":"4.5.0"},"reference-count":168,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine (Lond.)"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.2217\/nnm-2022-0261","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T07:29:57Z","timestamp":1678433397000},"page":"67-84","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":27,"title":["Nanodrug Delivery Systems for Metabolic Chronic Liver Diseases: Advances and Perspectives"],"prefix":"10.1080","volume":"18","author":[{"given":"Foteini","family":"Athanasopoulou","sequence":"first","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, W12 0BZ, UK"},{"name":"MRC London Institute of Medical Sciences, Du Cane Road, London, W12 0NN, UK"},{"name":"Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail","family":"Manolakakis","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, W12 0BZ, UK"},{"name":"MRC London Institute of Medical Sciences, Du Cane Road, London, W12 0NN, UK"},{"name":"Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Vernia","sequence":"additional","affiliation":[{"name":"MRC London Institute of Medical Sciences, Du Cane Road, London, W12 0NN, UK"},{"name":"Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazila","family":"Kamaly","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, W12 0BZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00523-4"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-313884"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.312"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.11.039"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29085"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.012"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.052"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010617-052545"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.003"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.005"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0104-9"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.012"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29273"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1712191"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.32.20180045"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i33.4169"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2012.01.010"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060947"},{"issue":"6","key":"e_1_3_4_22_1","first-page":"440","article-title":"Nonalcoholic steatohepatitis: clinical presentation, diagnosis, and treatment","volume":"2","author":"Stengel JZ","year":"2006","unstructured":"Stengel JZ , HarrisonSA. Nonalcoholic steatohepatitis: clinical presentation, diagnosis, and treatment. Gastroenterol. Hepatol. (NY)2(6), 440\u2013449 (2006).","journal-title":"Gastroenterol. Hepatol. (NY)"},{"key":"e_1_3_4_23_1","unstructured":"Ferguson D FinckBN. Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus. www.nature.com\/nrendo"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/07388551.2014.930017"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0392-8"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn900002m"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.0c00606"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2013.02.020"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200019c"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10143"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.04.016"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.08.039"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10311-018-00841-1"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S38378"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S68861"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9040359"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120586"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.601626"},{"key":"e_1_3_4_39_1","article-title":"Polymer nanoparticles for smart drug delivery","author":"Bennet D","year":"2014","unstructured":"Bennet D , KimS, BennetD, KimS. Polymer nanoparticles for smart drug delivery. Appl. Nanotechnol. Drug Deliv. (2014). www.intechopen.com\/state.item.id","journal-title":"Appl. Nanotechnol. Drug Deliv."},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA05889A"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-102680-9.00013-5"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2019-0010"},{"key":"e_1_3_4_44_1","first-page":"321","article-title":"Nanosystems for drug delivery: design, engineering, and applications","author":"Dhapte V","year":"2019","unstructured":"Dhapte V , PokharkarV. Nanosystems for drug delivery: design, engineering, and applications. Green Synth. Charact. Appl. Nanoparticles321\u2013345 (2019).","journal-title":"Green Synth. Charact. Appl. Nanoparticles"},{"key":"e_1_3_4_45_1","first-page":"225","article-title":"Gel-based delivery of neurotherapeutics via naso-brain pathways","author":"Mahajan HS","year":"2021","unstructured":"Mahajan HS , PatilPH. Gel-based delivery of neurotherapeutics via naso-brain pathways. Direct Nose-to-Brain Drug Deliv. Mech. Technol. Adv. Appl. Regul. Updat.225\u2013245 (2021).","journal-title":"Direct Nose-to-Brain Drug Deliv. Mech. Technol. Adv. Appl. Regul. Updat."},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2018.00360"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.156"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.16.5"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.01.013"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.02.011"},{"key":"e_1_3_4_51_1","unstructured":"Tsoi KM MacParlandSA MaX-Zet al. Mechanism of hard-nanomaterial clearance by the liver. (2016). www.nature.com\/naturematerials"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114238"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-017-0206-4"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173832"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4638192"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S129300"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2016.1178134"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40336-014-0053-3"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2009.06.022"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S185574"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b03184"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7PY01603D"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.12.017"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2010.06.007"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.01.020"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23081848"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.08.029"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn101643u"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10971-014-3494-2"},{"key":"e_1_3_4_70_1","first-page":"91","volume-title":"Chapter 4 - Multifunctional nanocrystals for cancer therapy: a potential nanocarrier [Internet]. Grumezescu AMBT-N for DD and T (Ed.)","author":"Joseph E","year":"2019","unstructured":"Joseph E , SinghviG. Chapter 4 - Multifunctional nanocrystals for cancer therapy: a potential nanocarrier [Internet]. Grumezescu AMBT-N for DD and T (Ed.), William Andrew Publishing, 91\u2013116 (2019). Available from: www.sciencedirect.com\/science\/article\/pii\/B9780128165058000072"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.01.065"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.01.021"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071811-150124"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.03.048"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.01.222"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2010.12.029"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB01611D"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.13.191"},{"key":"e_1_3_4_80_1","volume-title":"Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences.","author":"Ye H","year":"2018","unstructured":"Ye H , ShenZ, YuL, WeiM, LiY. Manipulating nanoparticle transport within blood flow through external forces: an exemplar of mechanics in nanomedicine. In: Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences.Royal Society Publishing, London, UK (2018)."},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801763105"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13591-x"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.10.014"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SM02686A"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16510-2"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8MH01527A"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S36111"},{"key":"e_1_3_4_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.110989"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2021.1992589"},{"key":"e_1_3_4_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.08.050"},{"key":"e_1_3_4_91_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2016.1276232"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2009.10.004"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S158696"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01238"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2018.01.015"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.01.016"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3776"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-2433"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29721"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2010.00471.x"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.06.013"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8101279"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S138108"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.02.019"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21358"},{"issue":"1","key":"e_1_3_4_106_1","first-page":"1053","article-title":"Nanomedicine: a new therapeutic approach in liver diseases","volume":"7","author":"Sharma H","year":"2019","unstructured":"Sharma H , Flora SJS PA, Naqvi S. Nanomedicine: a new therapeutic approach in liver diseases. Austin J. Nanomed. Nanotechnol.7(1), 1053 (2019).","journal-title":"Austin J. Nanomed. Nanotechnol."},{"key":"e_1_3_4_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.01.011"},{"key":"e_1_3_4_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00407"},{"key":"e_1_3_4_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31604"},{"key":"e_1_3_4_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.10.044"},{"key":"e_1_3_4_111_1","first-page":"1","article-title":"Association between bilirubin and risk of non-alcoholic fatty liver disease based on a prospective cohort study","volume":"6","author":"Tian J","year":"2016","unstructured":"Tian J , ZhongR, LiuCet al. Association between bilirubin and risk of non-alcoholic fatty liver disease based on a prospective cohort study. Sci. Rep.6, 1\u20139 (2016).","journal-title":"Sci. Rep."},{"key":"e_1_3_4_112_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2012.18.4.383"},{"key":"e_1_3_4_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.594574"},{"key":"e_1_3_4_114_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2015.21.4.319"},{"key":"e_1_3_4_115_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/21\/30\/305102"},{"key":"e_1_3_4_116_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S202821"},{"key":"e_1_3_4_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.02.027"},{"key":"e_1_3_4_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.11.003"},{"key":"e_1_3_4_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29881"},{"key":"e_1_3_4_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.09.004"},{"key":"e_1_3_4_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.10.030"},{"key":"e_1_3_4_122_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat0344"},{"key":"e_1_3_4_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c01007"},{"key":"e_1_3_4_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16991-2"},{"key":"e_1_3_4_125_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.38834"},{"key":"e_1_3_4_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2012.00996.x"},{"issue":"12","key":"e_1_3_4_127_1","first-page":"1022","article-title":"Experimental therapeutics: targeting the redox Achilles heel of cancer","volume":"8","author":"Cabello CM","year":"2007","unstructured":"Cabello CM , BairWB, WondrakGT. Experimental therapeutics: targeting the redox Achilles heel of cancer. Curr. Opin. Investig. Drugs8(12), 1022\u20131037 (2007).","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"e_1_3_4_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2614"},{"key":"e_1_3_4_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.04.011"},{"key":"e_1_3_4_130_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2015-0135"},{"key":"e_1_3_4_131_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.15.87"},{"key":"e_1_3_4_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7080097"},{"key":"e_1_3_4_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49262-2"},{"key":"e_1_3_4_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.10.020"},{"key":"e_1_3_4_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79479-5"},{"key":"e_1_3_4_136_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13163949"},{"key":"e_1_3_4_137_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S101285"},{"key":"e_1_3_4_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.37"},{"key":"e_1_3_4_139_1","doi-asserted-by":"publisher","DOI":"10.1080\/08982100701528047"},{"key":"e_1_3_4_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.02.029"},{"key":"e_1_3_4_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2018.11.018"},{"key":"e_1_3_4_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00445-3"},{"key":"e_1_3_4_143_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b00709"},{"key":"e_1_3_4_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00913"},{"key":"e_1_3_4_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.09.004"},{"key":"e_1_3_4_146_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1399301"},{"key":"e_1_3_4_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00651"},{"key":"e_1_3_4_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.07.046"},{"key":"e_1_3_4_149_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2018.1453830"},{"key":"e_1_3_4_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.03.039"},{"key":"e_1_3_4_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.02.042"},{"key":"e_1_3_4_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0669-6"},{"key":"e_1_3_4_153_1","first-page":"4041415","article-title":"The emerging role of nanomedicine in the management of nonalcoholic fatty liver disease: a state-of-the-art review","author":"Moosavian SA","year":"2021","unstructured":"Moosavian SA , SathyapalanT, JamialahmadiT, SahebkarA. The emerging role of nanomedicine in the management of nonalcoholic fatty liver disease: a state-of-the-art review. Bioinorg. Chem. Appl.4041415 (2021).","journal-title":"Bioinorg. Chem. Appl."},{"issue":"3","key":"e_1_3_4_154_1","first-page":"288","article-title":"Non-alcoholic fatty liver disease: controlling an emerging epidemic, challenges, and future directions","volume":"31","author":"Ofosu A","year":"2018","unstructured":"Ofosu A , RamaiD, ReddyM. Non-alcoholic fatty liver disease: controlling an emerging epidemic, challenges, and future directions. Ann. Gastroenterol.31(3), 288\u2013295 (2018).","journal-title":"Ann. Gastroenterol."},{"key":"e_1_3_4_155_1","first-page":"382184","article-title":"Efficient hepatic delivery of drugs: novel strategies and their significance","author":"Mishra N","year":"2013","unstructured":"Mishra N , YadavNP, RaiVKet al. Efficient hepatic delivery of drugs: novel strategies and their significance. Biomed Res. Int.382184 (2013).","journal-title":"Biomed Res. Int."},{"key":"e_1_3_4_156_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.181457"},{"key":"e_1_3_4_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00358-0"},{"key":"e_1_3_4_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.06.038"},{"key":"e_1_3_4_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.06.008"},{"key":"e_1_3_4_160_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082986"},{"key":"e_1_3_4_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.3"},{"key":"e_1_3_4_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0009-6"},{"key":"e_1_3_4_163_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112799857558"},{"key":"e_1_3_4_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154320"},{"issue":"1","key":"e_1_3_4_165_1","article-title":"Identification of 90 NAFLD GWAS loci and establishment of NAFLD PRS and causal role of NAFLD in coronary artery disease","volume":"3","author":"Miao Z","year":"2021","unstructured":"Miao Z , GarskeKM, PanDZet al. Identification of 90 NAFLD GWAS loci and establishment of NAFLD PRS and causal role of NAFLD in coronary artery disease. HGG Adv.3(1), (2021).","journal-title":"HGG Adv."},{"key":"e_1_3_4_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00502-9"},{"key":"e_1_3_4_167_1","doi-asserted-by":"publisher","DOI":"10.20517\/2394-5079.2020.92"},{"key":"e_1_3_4_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2020.02.040"},{"key":"e_1_3_4_169_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P056002"},{"key":"e_1_3_4_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109526"}],"container-title":["Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/nnm-2022-0261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:50:18Z","timestamp":1716479418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/nnm-2022-0261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":168,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.2217\/nnm-2022-0261"],"URL":"https:\/\/doi.org\/10.2217\/nnm-2022-0261","relation":{},"ISSN":["1743-5889","1748-6963"],"issn-type":[{"value":"1743-5889","type":"print"},{"value":"1748-6963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}