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Materials &amp; methods: FRET-LNCs of 85\u00a0or 50\u00a0nm with or without\u00a0a pegylated surface were injected and collected in the blood or urine of rats at different time points. Quantitative analysis was performed to measure intact FRET-LNCs. Results &amp; conclusion: No\u00a0intact LNCs were found in urine (0\u00a0particles\/ml) for all formulations. The\u00a050-nm pegylated LNCs were eliminated faster from the\u00a0blood, whereas 85-nm pegylated LNCS were eliminated slower than nonpegylated LNCs. 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