{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:31:57Z","timestamp":1777347117266,"version":"3.51.4"},"reference-count":101,"publisher":"Informa UK Limited","issue":"6","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Pharmacogenomics"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.2217\/pgs-2017-0195","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T08:25:24Z","timestamp":1522139124000},"page":"577-587","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":16,"title":["Pharmacogenetics of Oral Antidiabetic Therapy"],"prefix":"10.1080","volume":"19","author":[{"given":"Anna-Maria","family":"Ordelheide","sequence":"first","affiliation":[{"name":"Institute for Diabetes Research & Metabolic Diseases of the Helmholtz Centre Munich at the Eberhard Karls University T\u00fcbingen, Germany"},{"name":"German Center for Diabetes Research (DZD), Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hrab\u011b de Angelis","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"Institute of Experimental Genetics, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Neuherberg, Germany"},{"name":"Chair for Experimental Genetics, Technical University Munich, Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Ulrich","family":"H\u00e4ring","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research & Metabolic Diseases of the Helmholtz Centre Munich at the Eberhard Karls University T\u00fcbingen, Germany"},{"name":"German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Angiology, Nephrology & Clinical Chemistry, University Hospital T\u00fcbingen, Germany"},{"name":"Interfaculty Center for Pharmacogenomics & PharmaResearch at the Eberhard Karls University T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Staiger","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research & Metabolic Diseases of the Helmholtz Centre Munich at the Eberhard Karls University T\u00fcbingen, Germany"},{"name":"German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"Interfaculty Center for Pharmacogenomics & PharmaResearch at the Eberhard Karls University T\u00fcbingen, Germany"},{"name":"Institute of Pharmaceutical Sciences, Department of Pharmacy & Biochemistry, Eberhard Karls University T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2018,3,27]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00037"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12963-016-0110-4"},{"key":"e_1_3_3_4_1","unstructured":"IDF Diabetes Atlas \u2013 7th Edition . www.diabetesatlas.org ."},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05838.x"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1942"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2013.06.003"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-46314-3_9"},{"issue":"10","key":"e_1_3_3_9_1","first-page":"624","article-title":"The role of pharmacogenomic biomarkers in predicting and improving drug response: part 2: challenges impeding clinical implementation","volume":"38","author":"Ventola CL","year":"2013","unstructured":"Ventola CL . The role of pharmacogenomic biomarkers in predicting and improving drug response: part 2: challenges impeding clinical implementation . PT38 ( 10 ), 624 \u2013 627 ( 2013 ).","journal-title":"PT"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2016.05.002"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.02.008"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3182a562b7"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-2991-0"},{"issue":"4","key":"e_1_3_3_14_1","doi-asserted-by":"crossref","first-page":"6S28","DOI":"10.1016\/S1262-3636(03)72785-2","article-title":"Reducing insulin resistance with metformin: the evidence today","volume":"29","author":"Giannarelli R","year":"2003","unstructured":"Giannarelli R , AragonaM , CoppelliA , Del PratoS . Reducing insulin resistance with metformin: the evidence today . Diabetes Metab.29 ( 4 Pt 2 ), 6S28 \u2013 6S35 ( 2003 ).","journal-title":"Diabetes Metab."},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4372-6"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.3855"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07037-8"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.03.024"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.144"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1367"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066224"},{"issue":"7","key":"e_1_3_3_22_1","first-page":"658","article-title":"Metformin: current knowledge","volume":"19","author":"Nasri H","year":"2014","unstructured":"Nasri H , Rafieian-KopaeiM . Metformin: current knowledge . J. Res. Med. Sci.19 ( 7 ), 658 \u2013 664 ( 2014 ).","journal-title":"J. Res. Med. Sci."},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70050-6"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2012.11.005"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2015.12.363"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1388"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.20.379"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200309000-00007"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32832cc7e9"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.61"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328302cd41"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2015.01.024"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0347"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.210"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1028"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0543"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32834c0010"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.567"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-014-1774-y"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.735"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3632"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.7.2256"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.109"},{"key":"e_1_3_3_44_1","doi-asserted-by":"crossref","first-page":"374549","DOI":"10.1155\/2008\/374549","article-title":"PPAR genomics and pharmacogenomics: implications for cardiovascular disease","author":"Cresci S","year":"2008","unstructured":"Cresci S . PPAR genomics and pharmacogenomics: implications for cardiovascular disease . PPAR Res.2008 , 374549 ( 2008 ).","journal-title":"PPAR Res."},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-016-1135-1"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12567"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13144"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13075"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.21.2005"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109333"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2013.02.033"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X167354"},{"issue":"3","key":"e_1_3_3_53_1","first-page":"166","article-title":"Path to personalized medicine for Type 2 diabetes mellitus: reality and hope","volume":"55","author":"Aghaei Meybodi HR","year":"2017","unstructured":"Aghaei Meybodi HR , HasanzadM , LarijaniB . Path to personalized medicine for Type 2 diabetes mellitus: reality and hope . Acta Med. Iran55 ( 3 ), 166 \u2013 174 ( 2017 ).","journal-title":"Acta Med. Iran"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-017-6733-2"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2013.752813"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00006"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.suppl_2.S108"},{"issue":"1","key":"e_1_3_3_58_1","first-page":"e35","article-title":"Second-line therapy in patients with Type 2 diabetes inadequately controlled with metformin monotherapy: a systematic review and mixed-treatment comparison meta-analysis","volume":"5","author":"McIntosh B","year":"2011","unstructured":"McIntosh B , CameronC , SinghSRet al. Second-line therapy in patients with Type 2 diabetes inadequately controlled with metformin monotherapy: a systematic review and mixed-treatment comparison meta-analysis . Open Med.5 ( 1 ), e35 \u2013 e48 ( 2011 ).","journal-title":"Open Med."},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1943"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2015.95"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20150096"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2323"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.10.018"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-2248"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0440"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920009789375388"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2003.11.006"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12665"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2527"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2008.12.005"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0331-3"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706082"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.2147\/pgpm.s5806"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.108.000604"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1184"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3276-y"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0227"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181880"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154369"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005155"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12682"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.05.018"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14951"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1876-8"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.072884"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000152"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3828"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0393"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611925"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177148"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0000000000000268"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.11.69"},{"key":"e_1_3_3_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2015.39"},{"key":"e_1_3_3_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.281"},{"key":"e_1_3_3_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.119"},{"key":"e_1_3_3_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256426"},{"key":"e_1_3_3_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2016.03.008"},{"key":"e_1_3_3_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-663-4_7"},{"key":"e_1_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v4.i4.114"},{"key":"e_1_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0926-y"},{"key":"e_1_3_3_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(11)70008-0"},{"key":"e_1_3_3_102_1","unstructured":"US FDA . Table of pharmacogenomic biomarkers in drug labeling . www.fda.gov\/drugs\/scienceresearch\/researchareas\/pharmacogenetics\/ucm083378.htm ."}],"container-title":["Pharmacogenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/pgs-2017-0195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T10:24:12Z","timestamp":1719915852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/pgs-2017-0195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,27]]},"references-count":101,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.2217\/pgs-2017-0195"],"URL":"https:\/\/doi.org\/10.2217\/pgs-2017-0195","relation":{},"ISSN":["1462-2416","1744-8042"],"issn-type":[{"value":"1462-2416","type":"print"},{"value":"1744-8042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,27]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipgs20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipgs20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2017-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}