{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:11:20Z","timestamp":1784099480079,"version":"3.55.0"},"reference-count":41,"publisher":"Informa UK Limited","issue":"5-6","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81373838"],"award-info":[{"award-number":["81373838"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Pharmacogenomics"],"published-print":{"date-parts":[[2026,6,3]]},"DOI":"10.2217\/pgs-2017-0203","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T11:19:40Z","timestamp":1509621580000},"page":"227-235","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["Impact of\n                    <i>CYP2D6<\/i>\n                    and\n                    <i>ADRB1<\/i>\n                    polymorphisms on heart rate of post-PCI patients treated with metoprolol"],"prefix":"10.1080","volume":"27","author":[{"given":"Xiaofeng","family":"Gao","sequence":"first","affiliation":[{"name":"Fujian Provincial Cardiovascular Disease Institute, Fujian Medical University, Fuzhou, Fujian, P.R. China\u00a0"},{"name":"Ningde Hospital affiliated to Fujian Medical University,13 Mingdong East Road, Ningde, Fujian 352100, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Cardiovascular Disease Institute, Fujian Medical University, Fuzhou, Fujian, P.R. China\u00a0"},{"name":"Department of Internal Medicine, Fujian Provincal Cardiovascular Disease Institute, Provincial Clinical College of Fujian Medical University, 134 East Street, Fuzhou, Fujian 350001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Fujian Provincal Cardiovascular Disease Institute, Provincial Clinical College of Fujian Medical University, 134 East Street, Fuzhou, Fujian 350001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"issue":"7","key":"e_1_3_4_2_1","first-page":"552","article-title":"Summary of report on cardiovascular diseases in China, 2012","volume":"27","author":"Wang W","year":"2014","unstructured":"Wang W, Hu SS, Kong LZ et al. Summary of report on cardiovascular diseases in China, 2012. Biomed. Environ. Sci. 27(7), 552\u2013558 (2014).","journal-title":"Biomed. Environ. Sci."},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62216-9"},{"issue":"28","key":"e_1_3_4_4_1","first-page":"2272","article-title":"Effect of pathway training on rest heart rate and the application of beta-blocker in coronary heart disease patients: an open-label, multicenter, prospective study","volume":"95","author":"Li D","year":"2015","unstructured":"Li D, Dong W, Chen Y et al. Effect of pathway training on rest heart rate and the application of beta-blocker in coronary heart disease patients: an open-label, multicenter, prospective study. Zhonghua yi xue za zhi 95(28), 2272\u20132276 (2015).","journal-title":"Zhonghua yi xue za zhi"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212163072505"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.2.115"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00224-8"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-009-0076-5"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.10.1.17"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270004268128"},{"issue":"3","key":"e_1_3_4_11_1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0026-895X(25)09721-4","article-title":"Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation","volume":"46","author":"Johansson I","year":"1994","unstructured":"Johansson I, Oscarson M, Yue QY, Bertilsson L, Sjoqvist F, Ingelman-Sundberg M. Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol. Pharmacol. 46(3), 452\u2013459 (1994).","journal-title":"Mol. Pharmacol."},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.09.004"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.172"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.127111"},{"key":"e_1_3_4_15_1","unstructured":"Institute of Clinical Pharmacology Central South University. www.csupharmacol.com."},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2008.00945.x"},{"issue":"11","key":"e_1_3_4_17_1","first-page":"1256","article-title":"Simultaneous determination of metoprolol and its metabolites, alpha-hydroxymetoprolol and O-desmethylmetoprolol, in human plasma by liquid chromatography with tandem mass spectrometry: application to the pharmacokinetics of metoprolol associated with CYP2D6 genotypes","volume":"37","author":"Bae SH","year":"2014","unstructured":"Bae SH, Lee JK, Cho DY, Bae SK. Simultaneous determination of metoprolol and its metabolites, alpha-hydroxymetoprolol and O-desmethylmetoprolol, in human plasma by liquid chromatography with tandem mass spectrometry: application to the pharmacokinetics of metoprolol associated with CYP2D6 genotypes. J. Clin. Pharm. Ther. 37(11), 1256\u20131264 (2014).","journal-title":"J. Clin. Pharm. Ther."},{"key":"e_1_3_4_18_1","volume-title":"Hypertension: Management in Adults in Primary Care: Pharmacological Update","author":"National Collaborating Centre for Chronic Conditions","year":"2006","unstructured":"National Collaborating Centre for Chronic Conditions. Hypertension: Management in Adults in Primary Care: Pharmacological Update. Royal College of Physicians of London., London, UK (2006)."},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328333146d"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2011.562884"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001364"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs195"},{"issue":"28","key":"e_1_3_4_23_1","first-page":"2272","article-title":"Effect of pathway training on rest heart rate and the application of \u03b2-blocker in coronary heart disease patients: an open-label, multicenter, prospective study","volume":"95","author":"Dangdang L","year":"2015","unstructured":"Dangdang L, Wei D, Yundai C et al. Effect of pathway training on rest heart rate and the application of \u03b2-blocker in coronary heart disease patients: an open-label, multicenter, prospective study. Natl Med. J. China 95(28), 2272\u20132276 (2015).","journal-title":"Natl Med. J. China"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp358"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036284"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0250-8"},{"issue":"3","key":"e_1_3_4_27_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0090-9556(25)07354-4","article-title":"Metoprolol metabolism via cytochrome P450 2D6 in ethnic populations","volume":"24","author":"Johnson JA","year":"1996","unstructured":"Johnson JA, Burlew BS. Metoprolol metabolism via cytochrome P450 2D6 in ethnic populations. Drug Metab. Disposit. Biol. Fate Chem. 24(3), 350\u2013355 (1996).","journal-title":"Drug Metab. Disposit. Biol. Fate Chem."},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270004269582"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-2483-1"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2013.02.014"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.06.169"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.2165\/11318030-000000000-00000"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.02.007"},{"issue":"12","key":"e_1_3_4_34_1","first-page":"1780","article-title":"Genetic polymorphisms of CYP2D6 in Chinese mainland","volume":"115","author":"Ji L","year":"2002","unstructured":"Ji L, Pan S, Wu J, Marti-Jaun J, Hersberger M. Genetic polymorphisms of CYP2D6 in Chinese mainland. Chinese Med. J. 115(12), 1780\u20131784 (2002).","journal-title":"Chinese Med. J."},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/09540261.2013.825581"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199802000-00003"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.96"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.193"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.07.004"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.08.020"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67661-1"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12363"}],"container-title":["Pharmacogenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/pgs-2017-0203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.2217\/pgs-2017-0203","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/pgs-2017-0203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:54:58Z","timestamp":1784098498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/pgs-2017-0203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":41,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2026,6,3]]}},"alternative-id":["10.2217\/pgs-2017-0203"],"URL":"https:\/\/doi.org\/10.2217\/pgs-2017-0203","relation":{},"ISSN":["1462-2416","1744-8042"],"issn-type":[{"value":"1462-2416","type":"print"},{"value":"1744-8042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,31]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipgs20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipgs20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}