{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:20:45Z","timestamp":1781133645426,"version":"3.54.1"},"reference-count":17,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Pharmacogenomics"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.2217\/pgs-2018-0144","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T10:52:10Z","timestamp":1547117530000},"page":"85-93","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":15,"title":["Validation of a Clinical Pharmacogenetic Model to Predict Methotrexate Nonresponse in Rheumatoid Arthritis Patients"],"prefix":"10.1080","volume":"20","author":[{"given":"Frank","family":"Eektimmerman","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy &amp; Toxicology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Leiden Network for Personalised Therapeutics (LNPT), Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia F","family":"Allaart","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna MW","family":"Hazes","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Erasmus Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moenira B","family":"Madhar","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy &amp; Toxicology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfons A","family":"den Broeder","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap","family":"Fransen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse J","family":"Swen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy &amp; Toxicology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Leiden Network for Personalised Therapeutics (LNPT), Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk-Jan","family":"Guchelaar","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy &amp; Toxicology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Leiden Network for Personalised Therapeutics (LNPT), Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22783"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22640"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.12.83"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41397-018-0017-5"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7594"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012799"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204788"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203243"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket166"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390105"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.12.009"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.088237"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2016.36"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00020"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38113"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev421"}],"updated-by":[{"DOI":"10.2217\/pgs-2018-0144e","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000}}],"container-title":["Pharmacogenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/pgs-2018-0144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T23:31:00Z","timestamp":1715988660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/pgs-2018-0144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.2217\/pgs-2018-0144"],"URL":"https:\/\/doi.org\/10.2217\/pgs-2018-0144","relation":{"correction":[{"id-type":"doi","id":"10.2217\/pgs-2018-0144e","asserted-by":"object"}]},"ISSN":["1462-2416","1744-8042"],"issn-type":[{"value":"1462-2416","type":"print"},{"value":"1744-8042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipgs20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipgs20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}