{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T10:44:34Z","timestamp":1742381074622},"reference-count":73,"publisher":"Informa UK Limited","issue":"7","funder":[{"name":"NAGEMP (Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional","award":["573993\/2008-4"],"award-info":[{"award-number":["573993\/2008-4"]}]},{"name":"FIPE\/HCPA","award":["10-0410"],"award-info":[{"award-number":["10-0410"]}]},{"name":"Coordena\u00e7\u00e3o Brasileira de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Pharmacogenomics"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.2217\/pgs-2018-0192","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T09:52:18Z","timestamp":1558691538000},"page":"503-516","update-policy":"http:\/\/dx.doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["<i>NR3C1<\/i>\n            ,\n            <i>ABCB1<\/i>\n            ,\n            <i>TNF<\/i>\n            and\n            <i>CYP2C19<\/i>\n            Polymorphisms Association with the Response to the Treatment of Erythema Nodosum Leprosum"],"prefix":"10.1080","volume":"20","author":[{"given":"Perp\u00e9tua","family":"do Socorro Silva Costa","sequence":"first","affiliation":[{"name":"Postgraduate Program in Genetics &amp; Molecular Biology,\u00a0Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"},{"name":"INAGEMP, Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional, Porto Alegre, RS, Brazil"},{"name":"Center of Social Sciences, Health &amp; Technology, Universidade Federal do Maranh\u00e3o, Imperatriz, MA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thayne","family":"Woycinck Kowalski","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Genetics &amp; Molecular Biology,\u00a0Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"},{"name":"INAGEMP, Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional, Porto Alegre, RS, Brazil"},{"name":"Department of Morphological Sciences, Institute of Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"},{"name":"Teratogen Information Service, Medical Genetics Service, Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Rosa Fraga","sequence":"additional","affiliation":[{"name":"INAGEMP, Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional, Porto Alegre, RS, Brazil"},{"name":"Department of Morphological Sciences, Institute of Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"},{"name":"Teratogen Information Service, Medical Genetics Service, Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maril\u00e9a","family":"Furtado Feira","sequence":"additional","affiliation":[{"name":"INAGEMP, Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional, Porto Alegre, RS, Brazil"},{"name":"Center of Experimental Research, Genomics Medicine Laboratory &amp; Laboratory of Research in Bioethics &amp; Ethics in Research (LAPEBEC), Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Naz\u00e1rio","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre, Porto Alegre, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"MarceloAranha Camargo","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences-5, Universidade de S\u00e3o Paulo, Monte Negro, Rond\u00f4nia, Brazil"},{"name":"Center for Research in Tropical Medicine, Porto Velho, Rond\u00f4nia, Brazil"},{"name":"National Institute of Science and Technology-EpiAmo, Rond\u00f4nia, Brazil"},{"name":"Department of Medicine, Centro Universit\u00e1rio S\u00e3o Lucas, Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Iop de Oliveira Caldoncelli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Centro Universit\u00e1rio S\u00e3o Lucas, Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Irismar da Silva Silveira","sequence":"additional","affiliation":[{"name":"National Reference Center for Health Dermatology Dona Lib\u00e2nia \u2013 CDERM, Fortaleza, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara Helena","family":"Hutz","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Genetics &amp; Molecular Biology,\u00a0Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lav\u00ednia","family":"Sch\u00fcler-Faccini","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Genetics &amp; Molecular Biology,\u00a0Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"},{"name":"INAGEMP, Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional, Porto Alegre, RS, Brazil"},{"name":"Teratogen Information Service, Medical Genetics Service, Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Sales Luiz Vianna","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Genetics &amp; Molecular Biology,\u00a0Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"},{"name":"INAGEMP, Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional, Porto Alegre, RS, Brazil"},{"name":"Teratogen Information Service, Medical Genetics Service, Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre, RS, Brazil"},{"name":"Center of Experimental Research, Genomics Medicine Laboratory &amp; Laboratory of Research in Bioethics &amp; Ethics in Research (LAPEBEC), Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"issue":"3","key":"e_1_3_5_2_1","first-page":"255","article-title":"Classification of leprosy according to immunity. A five-group system","volume":"34","author":"Ridley DS","year":"1966","unstructured":"Ridley DS , JoplingWH. Classification of leprosy according to immunity. A five-group system. Int. J. Lepr. Other Mycobact. Dis.34(3), 255\u2013273 (1966).","journal-title":"Int. J. Lepr. Other Mycobact. Dis."},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762012000900020"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis208"},{"key":"e_1_3_5_5_1","unstructured":"Brazilian Ministry of Health . Diretrizes para vigil\u00e2ncia aten\u00e7\u00e3o e eliminacao da hansen\u00edase como problema de sa\u00fade p\u00fablica: manual t\u00e9cnico-operacional hanseniase (2016). http:\/\/portalsaude.saude.gov.br\/images\/pdf\/2016\/fevereiro\/04\/diretrizes-eliminacao-hanseniase-4fev16-web.pdf"},{"issue":"5","key":"e_1_3_5_6_1","doi-asserted-by":"crossref","DOI":"10.4269\/ajtmh.2006.74.868","article-title":"Clinical course of erythema nodosum leprosum: an 11-year cohort study in Hyderabad, India","volume":"74","author":"Pocaterra L","year":"2006","unstructured":"Pocaterra L , JainS , ReddyRet al. Clinical course of erythema nodosum leprosum: an 11-year cohort study in Hyderabad, India. Am. J. Trop. Med. Hyg.74(5), 868\u2013879 (2006).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962008000100010"},{"key":"e_1_3_5_8_1","first-page":"103","article-title":"Serum levels of tumour necrosis factor-alpha and interleukin-1 beta during leprosy reactional states","volume":"84","author":"Sarno EN","year":"1991","unstructured":"Sarno EN , GrauGE , VieiraLM , NeryJA. Serum levels of tumour necrosis factor-alpha and interleukin-1 beta during leprosy reactional states. Clin. Exp. Immunol.84, 103\u2013108 (1991).","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.01.026"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.47276\/lr.82.3.213"},{"issue":"189","key":"e_1_3_5_11_1","article-title":"The effects of prednisolone treatment on cytokine expression in patients with erythema nodosum leprosum reactions","volume":"9","author":"Negera E","year":"2018","unstructured":"Negera E , WalkerSL , BoboshaKet al. The effects of prednisolone treatment on cytokine expression in patients with erythema nodosum leprosum reactions. Front. Immunol.9(189), (2018).","journal-title":"Front. Immunol."},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.47276\/lr.80.4.355"},{"issue":"1","key":"e_1_3_5_13_1","first-page":"10","article-title":"Leprosy reactions \u2013 complications of steroid therapy","volume":"66","author":"Sugumaran DS","year":"1998","unstructured":"Sugumaran DS . Leprosy reactions \u2013 complications of steroid therapy. Int. J. Lepr. Other Mycobact. Dis.66(1), 10\u201315 (1998).","journal-title":"Int. J. Lepr. Other Mycobact. Dis."},{"key":"e_1_3_5_14_1","first-page":"389","article-title":"Erythema nodosum leprosum: clinical and therapeutic update","volume":"77","author":"Guerra J","year":"2002","unstructured":"Guerra J , PennaG , de CastroL , MartelliC , StefaniM. Erythema nodosum leprosum: clinical and therapeutic updateAn Bras Dermatol.77, 389\u2013407 (2002).","journal-title":"An Bras Dermatol."},{"key":"e_1_3_5_15_1","unstructured":"Penna GO MartelliCMT MarojaMDF. Thalidomide in the treatment of erythema nodosum leprosum (ENL): systematic review of clinical trials and prospects of new investigation. 80(5) 511\u2013522 (2005)."},{"key":"e_1_3_5_16_1","first-page":"1","article-title":"Projeto diretrizes hansen\u00edase: epis\u00f3dios reacionais projeto diretrizes","author":"Sociedade Brasileira de Hansenologia","year":"2003","unstructured":"Sociedade Brasileira de Hansenologia , SociedadeBrasileira de Dermatologia. Projeto diretrizes hansen\u00edase: epis\u00f3dios reacionais projeto diretrizes. Associa\u00e7\u00e3o M\u00e9dica Brasileira e Conselho Federal de Medicina1\u201319 (2003). www.saudedireta.com.br\/docsupload\/1331325697056.pdf","journal-title":"Associa\u00e7\u00e3o M\u00e9dica Brasileira e Conselho Federal de Medicina"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.47276\/lr.79.3.254"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.6.1675"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.3.699"},{"issue":"4","key":"e_1_3_5_20_1","first-page":"253","article-title":"The management of erythema nodosum leprosum: current and future options","volume":"67","author":"Lockwood DN","year":"1996","unstructured":"Lockwood DN . The management of erythema nodosum leprosum: current and future options. Lepr. Rev.67(4), 253\u2013259 (1996).","journal-title":"Lepr. Rev."},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06747.x"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.09.039"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/41231"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2014.07.015"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206948"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22163"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.6.2263"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.01.011"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2016.17.3.1009"},{"issue":"6","key":"e_1_3_5_30_1","first-page":"1964","article-title":"Thalidomide metabolism by the CYP2C subfamily","volume":"8","author":"Ando Y","year":"2002","unstructured":"Ando Y , FuseE , FiggWD. Thalidomide metabolism by the CYP2C subfamily. Clin. Cancer Res.8(6), 1964\u20131973 (2002).","journal-title":"Clin. Cancer Res."},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.992"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2018.02.026"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2016-0131"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.13"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.7.3195"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.08.049"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1998.tb03002.x"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1086\/319501"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1086\/379378"},{"key":"e_1_3_5_41_1","volume-title":"Desequil\u00edbrio de liga\u00e7\u00f5es e blocos de hapl\u00f3tipos determinados pelas an\u00e1lises de 250k SNPS em tr\u00eas remanescentes de Quilombos [Doctoral dissertation]","author":"Andrade E. S.","year":"2013","unstructured":"Andrade E. S. . Desequil\u00edbrio de liga\u00e7\u00f5es e blocos de hapl\u00f3tipos determinados pelas an\u00e1lises de 250k SNPS em tr\u00eas remanescentes de Quilombos [Doctoral dissertation]. Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil (2013)."},{"key":"e_1_3_5_42_1","unstructured":"Brazilian Ministry of Health . Guia pr\u00e1tico sobre a Hansen\u00edase1 (2017). http:\/\/portalarquivos2.saude.gov.br\/images\/pdf\/2017\/novembro\/22\/Guia-Pratico-de-Hanseniase-WEB.pdf"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.11.034"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2016.0253"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i31.3888"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05013.x"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00184"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21608"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)35757-0"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200308000-00006"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000308"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.7.3473"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00542"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200104000-00005"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.114164"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2011.02602.x"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15028199"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir521"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(97)00052-7"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1996.d01-65.x"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.06.021"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20170806"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.11.1281"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.41984"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-010-0641-x"},{"issue":"3","key":"e_1_3_5_66_1","first-page":"325","article-title":"Tumor necrosis factor promoter polymorphism (TNF2) seems to protect against development of severe forms of leprosy in a pilot study in Brazilian patients","volume":"68","author":"Santos AR","year":"2000","unstructured":"Santos AR , AlmeidaAS , SuffysPNet al. Tumor necrosis factor promoter polymorphism (TNF2) seems to protect against development of severe forms of leprosy in a pilot study in Brazilian patients. Int. J. Lepr. Other Mycobact. Dis.68(3), 325\u2013327 (2000).","journal-title":"Int. J. Lepr. Other Mycobact. Dis."},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2011.0285"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.47276\/lr.87.2.221"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822004000500003"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1489\/1544-581X(2004)072<0125:ECOLRY>2.0.CO;2"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002440"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004065"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003431"},{"key":"e_1_3_5_74_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2007000200011"}],"container-title":["Pharmacogenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/pgs-2018-0192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:44:41Z","timestamp":1715993081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/pgs-2018-0192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":73,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.2217\/pgs-2018-0192"],"URL":"https:\/\/doi.org\/10.2217\/pgs-2018-0192","relation":{},"ISSN":["1462-2416","1744-8042"],"issn-type":[{"value":"1462-2416","type":"print"},{"value":"1744-8042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipgs20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipgs20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}