{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:49:57Z","timestamp":1780404597266,"version":"3.54.1"},"reference-count":99,"publisher":"Informa UK Limited","issue":"12","funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health"},{"name":"Human Development of the National Institutes of Health","award":["R01HD089458"],"award-info":[{"award-number":["R01HD089458"]}]},{"name":"Human Development of the National Institutes of Health","award":["R21HD094311"],"award-info":[{"award-number":["R21HD094311"]}]},{"name":"Human Development of the National Institutes of Health","award":["R01HD096800"],"award-info":[{"award-number":["R01HD096800"]}]},{"name":"University School of Medicine"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Pharmacogenomics"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.2217\/pgs-2020-0040","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T09:33:14Z","timestamp":1595583194000},"page":"871-887","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":22,"title":["Pharmacogenomics of Methadone: A Narrative Review of the Literature"],"prefix":"10.1080","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0248-5430","authenticated-orcid":false,"given":"Senthil","family":"Packiasabapathy","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-6454","authenticated-orcid":false,"given":"Blessed W","family":"Aruldhas","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN46202, USA"},{"name":"Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN46202, USA"},{"name":"Department of Pharmacology &amp; Clinical Pharmacology, Christian Medical College, Vellore, 632002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-9916","authenticated-orcid":false,"given":"Brian R","family":"Overholser","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN46202, USA"},{"name":"Department of Pharmacy Practice, Purdue University College of Pharmacy, Indianapolis, IN\u00a047907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-0695","authenticated-orcid":false,"given":"Sara K","family":"Quinney","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN46202, USA"},{"name":"Department of Obstetrics &amp; Gynecology, Indiana University School of Medicine, Indianapolis, IN\u00a046202, USA"},{"name":"Center for Computational Biology &amp; Bioinformatics, Indiana University School of Medicine, Indianapolis, IN\u00a046202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4197-3808","authenticated-orcid":false,"given":"Janelle S","family":"Renschler","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-8313","authenticated-orcid":false,"given":"Senthilkumar","family":"Sadhasivam","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181d8a095"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001609"},{"issue":"3","key":"e_1_3_3_5_1","first-page":"1263","article-title":"Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception","volume":"274","author":"Codd EE","year":"1995","unstructured":"Codd EE , ShankRP , SchupskyJJ , RaffaRB. Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J. Pharmacol. Exp. Ther.274(3), 1263\u20131270 (1995).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2008.01990.x"},{"key":"e_1_3_3_7_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.5935\/1806-0013.20150012","article-title":"Revisiting methadone: pharmacokinetics, pharmacodynamics and clinical indication","volume":"16","author":"Barbosa Neto JO","year":"2015","unstructured":"Barbosa Neto JO , GarciaMA , GarciaJBS. Revisiting methadone: pharmacokinetics, pharmacodynamics and clinical indication. Revista Dor.16, 60\u201366 (2015).","journal-title":"Revista Dor."},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005200000180"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003025"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002755"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00270-8"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00322-2"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000099723.75548.DF"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)13391-2"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2009\/12\/679"},{"issue":"2","key":"e_1_3_3_16_1","first-page":"1048","article-title":"D-methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia","volume":"289","author":"Davis AM","year":"1999","unstructured":"Davis AM , InturrisiCE. D-methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia. J. Pharmacol. Exp. Ther.289(2), 1048\u20131053 (1999).","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"e_1_3_3_17_1","first-page":"229","article-title":"Methadone, QTc prolongation and torsades de pointes: current concepts, management and a hidden twist in the tale?","volume":"4","author":"Mujtaba S","year":"2013","unstructured":"Mujtaba S , RomeroJ , TaubCC. Methadone, QTc prolongation and torsades de pointes: current concepts, management and a hidden twist in the tale?J. Cardiovasc. Dis. Res.4(4), 229\u201335 (2013).","journal-title":"J. Cardiovasc. Dis. Res."},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpp.JPP_163_17"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.038240"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.01.040"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874473710801030297"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X11311030006"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-0590(83)80101-8"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.13.58"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.07.013"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.09.010"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2018-0017"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.07.009"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/PGPM.S29272"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.11.96"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.127"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.02.002"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2017-0072"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328320a3fd"},{"issue":"2","key":"e_1_3_3_35_1","first-page":"194","article-title":"Association between DRD2 gene polymorphisms and the dosage used on methadone maintenance treatment program","volume":"39","author":"Duan LX","year":"2018","unstructured":"Duan LX , LiXL , HuPW , LuoR , LuoX , ChenYY. Association between DRD2 gene polymorphisms and the dosage used on methadone maintenance treatment program. Zhonghua Liu Xing Bing Xue Za Zhi.39(2), 194\u2013198 (2018).","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi."},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2011.6"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00386.x"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199606000-00001"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241140-00003"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2000.tb139323.x"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2006.00289.x"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315479"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181986a9a"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-016-0415-2"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2004.02079.x"},{"issue":"7","key":"e_1_3_3_46_1","first-page":"1353","article-title":"Methadone treatment for pain states","volume":"71","author":"Toombs JD","year":"2005","unstructured":"Toombs JD , KralLA. Methadone treatment for pain states. Am. Fam. Physician71(7), 1353\u20131358 (2005).","journal-title":"Am. Fam. Physician"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.34"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1990.37"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600740718"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1081\/DMR-100104402"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199710000-00185"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-015-0137-4"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx950116m"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00921.x"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.10303"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2010.00628.x"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.104"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.276"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182423478"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.12.009"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181642938"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.117580"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.027854"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182918252"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256276"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.09.012"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086114"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000867"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000437"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00274.x"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.08.011"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e318222b5dd"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.10.014"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019527"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkw135"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32835cb2e2"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005910"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2012.0068"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bku091"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200104000-00016"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/741403"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.3109\/00952990.2016.1172078"},{"issue":"3","key":"e_1_3_3_83_1","first-page":"1021","article-title":"Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation","volume":"298","author":"Oda Y","year":"2001","unstructured":"Oda Y , KharaschED. Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. J. Pharmacol. Exp. Ther.298(3), 1021\u20131032 (2001).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2003.02053.x"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000391"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.116793"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3180592ad2"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32833947c2"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.054866"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00024"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100120"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231467"},{"key":"e_1_3_3_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.690"},{"key":"e_1_3_3_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1997"},{"key":"e_1_3_3_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00012"},{"key":"e_1_3_3_96_1","doi-asserted-by":"publisher","DOI":"10.2165\/11318030-000000000-00000"},{"key":"e_1_3_3_97_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32833225e7"},{"key":"e_1_3_3_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12385"},{"key":"e_1_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12021"},{"key":"e_1_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26207"},{"key":"e_1_3_3_101_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318238fec5"}],"container-title":["Pharmacogenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/pgs-2020-0040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T10:28:28Z","timestamp":1715941708000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/pgs-2020-0040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,24]]},"references-count":99,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.2217\/pgs-2020-0040"],"URL":"https:\/\/doi.org\/10.2217\/pgs-2020-0040","relation":{},"ISSN":["1462-2416","1744-8042"],"issn-type":[{"value":"1462-2416","type":"print"},{"value":"1744-8042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,24]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipgs20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipgs20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}