{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:12:28Z","timestamp":1777497148152,"version":"3.51.4"},"reference-count":50,"publisher":"Informa UK Limited","issue":"8","funder":[{"name":"Taiwan Department of Health Clinical Trial","award":["DOH100-TD-B-111-004"],"award-info":[{"award-number":["DOH100-TD-B-111-004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacogenomics"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.2217\/pgs.11.64","type":"journal-article","created":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T15:52:58Z","timestamp":1312213978000},"page":"1107-1117","source":"Crossref","is-referenced-by-count":53,"title":["Association of Genetic Variants in Six Candidate Genes with Valproic Acid Therapy Optimization"],"prefix":"10.1080","volume":"12","author":[{"given":"Chin-Chuan","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan"},{"name":"Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Ling","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Lun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Jen","family":"Tai","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, College of Public Health, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Jen","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, College of Public Health, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yow-Wen","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan"},{"name":"Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horng-Huei","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Pharmacology, National Taiwan University Hospital &amp; College of Medicine, National Taiwan University, Taipei, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2011,8,15]]},"reference":[{"key":"e_1_3_3_3_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00075-6"},{"key":"e_1_3_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1779"},{"key":"e_1_3_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2005.04.010"},{"key":"e_1_3_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200216100-00003"},{"key":"e_1_3_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(00)00013-9"},{"key":"e_1_3_3_3_6_1","first-page":"42","article-title":"An association between the FABP2 gene polymorphism and efficacy of valproates.","volume":"107","author":"Aksenova MG","year":"2007","unstructured":"Aksenova MG , BurdSG, KachalinEY et al. An association between the FABP2 gene polymorphism and efficacy of valproates. Zh Nevrol. Psikhiatr. Im. S S Korsakova 107 , 42\u201345 (2007).","journal-title":"Zh Nevrol. Psikhiatr. Im. S S Korsakova"},{"key":"e_1_3_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.23.13317"},{"key":"e_1_3_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00070.2001"},{"key":"e_1_3_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-198903000-00002"},{"key":"e_1_3_3_3_10_1","first-page":"25","volume":"37","author":"DeVane CL","year":"2003","unstructured":"DeVane CL . Pharmacokinetics, drug interactions, and tolerability of valproate. Psychopharmacol. Bull.37(Suppl. 2) , 25\u201342 (2003).","journal-title":"Psychopharmacol. Bull."},{"key":"e_1_3_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00076-5"},{"key":"e_1_3_3_3_12_1","first-page":"507","volume":"26","author":"Green MD","year":"1998","unstructured":"Green MD , KingCD, MojarrabiB, MackenziePI, TephlyTR. Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. Drug Metab. Dispos.26 , 507\u2013512 (1998).","journal-title":"Drug Metab. Dispos."},{"key":"e_1_3_3_3_13_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0090-9556(25)07355-6","volume":"24","author":"Green MD","year":"1996","unstructured":"Green MD , TephlyTR. Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein. Drug Metab. Dispos.24 , 356\u2013363 (1996).","journal-title":"Drug Metab. Dispos."},{"key":"e_1_3_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.022426"},{"key":"e_1_3_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2006.01.002"},{"key":"e_1_3_3_3_16_1","first-page":"73","volume":"26","author":"Coffman BL","year":"1998","unstructured":"Coffman BL , KingCD, RiosGR, TephlyTR. The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268). Drug Metab. Dispos.26 , 73\u201377 (1998).","journal-title":"Drug Metab. Dispos."},{"key":"e_1_3_3_3_17_1","first-page":"1","volume":"25","author":"Coffman BL","year":"1997","unstructured":"Coffman BL , RiosGR, KingCD, TephlyTR. Human UGT2B7 catalyzes morphine glucuronidation. Drug Metab. Dispos.25 , 1\u20134 (1997).","journal-title":"Drug Metab. Dispos."},{"key":"e_1_3_3_3_18_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0022-3565(25)10294-2","volume":"264","author":"Jin C","year":"1993","unstructured":"Jin C , MinersJO, LillywhiteKJ, MackenziePI. Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. J. Pharmacol. Exp. Ther.264 , 475\u2013479 (1993).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.10.6908"},{"key":"e_1_3_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.5.677"},{"key":"e_1_3_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200011000-00002"},{"key":"e_1_3_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000114754.08559.27"},{"key":"e_1_3_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.081968"},{"key":"e_1_3_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.1.133"},{"key":"e_1_3_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.106.009787"},{"key":"e_1_3_3_3_26_1","first-page":"2033","volume":"87","author":"Sun YP","year":"2007","unstructured":"Sun YP , TanL, WangY, SongJH. [Effect of UGT1A6 genetic polymorphisms on the metabolism of sodium valproate]. Zhonghua Yi Xue Za Zhi87 , 2033\u20132035 (2007).","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_3_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407346102"},{"key":"e_1_3_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000230114.41828.73"},{"key":"e_1_3_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/516650"},{"key":"e_1_3_3_3_30_1","author":"Depondt C","year":"2011","unstructured":"Depondt C , GodardP, EspelRS, Da Cruz AL, Lienard P, Pandolfo M. A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity. Eur.J. Neurol. (2011).","journal-title":"Eur.J. Neurol."},{"key":"e_1_3_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05316.x"},{"key":"e_1_3_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02397.x"},{"key":"e_1_3_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.10.075"},{"key":"e_1_3_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e318187972a"},{"key":"e_1_3_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000114771.78957.cb"},{"key":"e_1_3_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001152"},{"key":"e_1_3_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.83"},{"key":"e_1_3_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.102491"},{"key":"e_1_3_3_3_39_1","first-page":"921","volume":"12","author":"Excoffier L","year":"1995","unstructured":"Excoffier L , SlatkinM. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol. Biol. Evol.12 , 921\u2013927 (1995).","journal-title":"Mol. Biol. Evol."},{"key":"e_1_3_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/50.4.757"},{"key":"e_1_3_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/49.1.49"},{"key":"e_1_3_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2052"},{"key":"e_1_3_3_3_43_1","first-page":"429","volume":"12","author":"Wang Y","year":"2010","unstructured":"Wang Y , GaoL, LiuYP, HuangNN, XuSJ, MaDJ. [Effect of UGTIA6 A541G genetic polymorphism on the metabolism of valproic acid in Han epileptic children from Henan]. Zhongguo Dang Dai Er Ke Za Zhi12 , 429\u2013432 (2010).","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"e_1_3_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100324"},{"key":"e_1_3_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.023"},{"key":"e_1_3_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500139"},{"key":"e_1_3_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100073"},{"key":"e_1_3_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500327"},{"key":"e_1_3_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181ceecc6"},{"key":"e_1_3_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.10380"}],"container-title":["Pharmacogenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/pgs.11.64","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:24:29Z","timestamp":1741393469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/pgs.11.64"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.2217\/pgs.11.64"],"URL":"https:\/\/doi.org\/10.2217\/pgs.11.64","relation":{},"ISSN":["1462-2416","1744-8042"],"issn-type":[{"value":"1462-2416","type":"print"},{"value":"1744-8042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}