{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:49:01Z","timestamp":1788871741315,"version":"build-2803163510"},"reference-count":30,"publisher":"Informa UK Limited","issue":"13","funder":[{"name":"HIR MOHE","award":["E000025-20001"],"award-info":[{"award-number":["E000025-20001"]}]},{"name":"Hong Kong Special Administrative Region, China","award":["CUHK4466\/06M"],"award-info":[{"award-number":["CUHK4466\/06M"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacogenomics"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.2217\/pgs.12.127","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T06:32:03Z","timestamp":1350023523000},"page":"1477-1485","source":"Crossref","is-referenced-by-count":23,"title":["<i>SCN1A<\/i>\n                    IVS5N+5 Polymorphism and Response to Sodium Valproate: A Multicenter Study"],"prefix":"10.1080","volume":"13","author":[{"given":"Batoul Sadat","family":"Haerian","sequence":"first","affiliation":[{"name":"Pharmacogenomics Laboratory, Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Baum","sequence":"additional","affiliation":[{"name":"School of Pharmacy, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Jan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kwan","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine &amp; Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azman Ali","family":"Raymond","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Saruwatari","sequence":"additional","affiliation":[{"name":"Division of Pharmacology &amp; Therapeutics, Graduate School of Medical &amp; Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Division of Pharmacology &amp; Therapeutics, Graduate School of Medical &amp; Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahurin","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Pharmacogenomics Laboratory, Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2012,10,12]]},"reference":[{"key":"e_1_3_4_3_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004418"},{"key":"e_1_3_4_3_2_1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1684\/j.1950-6945.2005.tb00145.x","volume":"7","author":"L\u00f6scher W","year":"2005","unstructured":"L\u00f6scher W . Mechanisms of drug resistance. Epileptic Disord.7(Suppl. 1) , S3\u2013S9 (2005).","journal-title":"Epileptic Disord."},{"key":"e_1_3_4_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(11)70497-2"},{"key":"e_1_3_4_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7079-x"},{"key":"e_1_3_4_3_5_1","first-page":"479364","article-title":"Molecular and therapeutic potential and toxicity of valproic acid.","author":"Chateauvieux S","year":"2010","unstructured":"Chateauvieux S , MorceauF, DicatoM et al. Molecular and therapeutic potential and toxicity of valproic acid. J. Biomed. Biotechnol. pii , 479364 (2010).","journal-title":"J. Biomed. Biotechnol."},{"key":"e_1_3_4_3_6_1","first-page":"function","volume":"1","author":"Catterall WA","year":"2012","unstructured":"Catterall WA . Voltage-gated sodium channels at 60: structure, function, and pathophysiology. J. Physiol.1 , 2577\u20132589 (2012).","journal-title":"J. Physiol."},{"key":"e_1_3_4_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2007.03.018"},{"key":"e_1_3_4_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.08.021"},{"key":"e_1_3_4_3_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10238"},{"key":"e_1_3_4_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70059-4"},{"key":"e_1_3_4_3_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802612800229206"},{"key":"e_1_3_4_3_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0601-x"},{"key":"e_1_3_4_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2004.02.001"},{"key":"e_1_3_4_3_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-13-05300.2002"},{"key":"e_1_3_4_3_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.250225"},{"key":"e_1_3_4_3_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407346102"},{"key":"e_1_3_4_3_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/516650"},{"key":"e_1_3_4_3_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000230114.41828.73"},{"key":"e_1_3_4_3_19_1","first-page":"57","article-title":"Association study of the SCN1 gene polymorphism and effective dose of lamotrigine.","volume":"109","author":"Krikova EV","year":"2009","unstructured":"Krikova EV , Val\u2018dmanEA, AvakianGN et al. Association study of the SCN1 gene polymorphism and effective dose of lamotrigine. Zh. Nevrol. Psikhiatr. Im. S S Korsakova 109 , 57\u201362 (2009).","journal-title":"Zh. Nevrol. Psikhiatr. Im. S S Korsakova"},{"key":"e_1_3_4_3_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01549_4.x"},{"key":"e_1_3_4_3_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03203.x"},{"key":"e_1_3_4_3_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283117d67"},{"key":"e_1_3_4_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2009.12.004"},{"key":"e_1_3_4_3_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03097.x"},{"key":"e_1_3_4_3_25_1","first-page":"1000","volume":"52","author":"Thompson CH","year":"2011","unstructured":"Thompson CH , KahligKM, GeorgeAL Jr. SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs. Epilepsia52 , 1000\u20131009 (2011).","journal-title":"SCN1A"},{"key":"e_1_3_4_3_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1981.tb06159.x"},{"key":"e_1_3_4_3_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03288.x"},{"key":"e_1_3_4_3_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02397.x"},{"key":"e_1_3_4_3_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-6-50"},{"key":"e_1_3_4_4_2_1","unstructured":"Meta-analysis made easy. www.meta-analysis-made-easy.com"}],"container-title":["Pharmacogenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/pgs.12.127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T07:01:15Z","timestamp":1715929275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/pgs.12.127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":30,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.2217\/pgs.12.127"],"URL":"https:\/\/doi.org\/10.2217\/pgs.12.127","relation":{},"ISSN":["1462-2416","1744-8042"],"issn-type":[{"value":"1462-2416","type":"print"},{"value":"1744-8042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}