{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:33:13Z","timestamp":1791232393436,"version":"4.1.0"},"reference-count":92,"publisher":"Informa UK Limited","issue":"14","funder":[{"name":"Pfizer and Novartis"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacogenomics"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.2217\/pgs.12.142","type":"journal-article","created":{"date-parts":[[2012,11,13]],"date-time":"2012-11-13T18:27:26Z","timestamp":1352831246000},"page":"1621-1633","source":"Crossref","is-referenced-by-count":10,"title":["Constitutional Genetic Variants as Predictors of Antiangiogenic Therapy Outcome in Renal Cell Carcinoma"],"prefix":"10.1080","volume":"13","author":[{"given":"Cristina","family":"Rodr\u00edguez-Antona","sequence":"first","affiliation":[{"name":"Hereditary Endocrine Cancer Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, 28029, Madrid, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Garc\u00eda-Donas","sequence":"additional","affiliation":[{"name":"Genitourinary, Neuroendocrine & Rare Tumors Programme, Centro Integral Oncol\u00f3gico Clara Campal, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2012,11,13]]},"reference":[{"key":"e_1_3_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_3_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_3_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.12.001"},{"key":"e_1_3_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011023431804"},{"key":"e_1_3_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.06.049"},{"key":"e_1_3_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0382"},{"key":"e_1_3_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493574"},{"key":"e_1_3_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0597-68"},{"key":"e_1_3_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00104-6"},{"key":"e_1_3_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/376435"},{"key":"e_1_3_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043172"},{"key":"e_1_3_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cad.0000390768.93282.65"},{"key":"e_1_3_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.06.047"},{"key":"e_1_3_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60229-4"},{"key":"e_1_3_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.061"},{"key":"e_1_3_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002312"},{"key":"e_1_3_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059796"},{"key":"e_1_3_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.16.4298"},{"key":"e_1_3_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/35017054"},{"key":"e_1_3_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/20459"},{"key":"e_1_3_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10595"},{"key":"e_1_3_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.016"},{"key":"e_1_3_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2007.64"},{"key":"e_1_3_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70380-8"},{"key":"e_1_3_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(99)00005-0"},{"key":"e_1_3_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200105000-00012"},{"key":"e_1_3_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.29.15_suppl.4506"},{"key":"e_1_3_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2530"},{"key":"e_1_3_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.1.289"},{"key":"e_1_3_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq342"},{"key":"e_1_3_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.4809"},{"key":"e_1_3_2_3_32_1","first-page":"CD001425","volume":"1","author":"Coppin C","year":"2005","unstructured":"Coppin C , PorzsoltF, AwaA, KumpfJ, ColdmanA, WiltT. Immunotherapy for advanced renal cell cancer. Cochrane Database Syst. Rev.1 , CD001425 (2005).","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.122"},{"key":"e_1_3_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.5.6.1031"},{"key":"e_1_3_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.57"},{"key":"e_1_3_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24241"},{"key":"e_1_3_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.30.15_suppl.4501"},{"key":"e_1_3_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.06.017"},{"key":"e_1_3_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61613-9"},{"key":"e_1_3_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61039-9"},{"key":"e_1_3_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2323"},{"key":"e_1_3_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0708842"},{"key":"e_1_3_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02626"},{"key":"e_1_3_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.126"},{"key":"e_1_3_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3722"},{"key":"e_1_3_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61904-7"},{"key":"e_1_3_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.9847"},{"key":"e_1_3_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.7849"},{"key":"e_1_3_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.5561"},{"key":"e_1_3_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1612"},{"key":"e_1_3_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03896.x"},{"key":"e_1_3_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-247"},{"key":"e_1_3_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2011.37"},{"key":"e_1_3_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0351"},{"key":"e_1_3_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.11.011"},{"key":"e_1_3_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70231-0"},{"key":"e_1_3_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060655"},{"key":"e_1_3_2_3_58_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.5511"},{"key":"e_1_3_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-009-1096-4"},{"key":"e_1_3_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2484"},{"key":"e_1_3_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-29-95"},{"key":"e_1_3_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065044"},{"key":"e_1_3_2_3_63_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.1293"},{"key":"e_1_3_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.06.032"},{"key":"e_1_3_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.30.5_suppl.359"},{"key":"e_1_3_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70266-2"},{"key":"e_1_3_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26491"},{"key":"e_1_3_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq150"},{"key":"e_1_3_2_3_69_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-1828"},{"key":"e_1_3_2_3_70_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.7679"},{"key":"e_1_3_2_3_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605813"},{"key":"e_1_3_2_3_72_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2010.543696"},{"key":"e_1_3_2_3_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.05.034"},{"key":"e_1_3_2_3_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-120"},{"key":"e_1_3_2_3_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-695"},{"key":"e_1_3_2_3_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.72"},{"key":"e_1_3_2_3_77_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.9764"},{"key":"e_1_3_2_3_78_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.9110"},{"key":"e_1_3_2_3_79_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3965"},{"key":"e_1_3_2_3_80_1","first-page":"S7505","article-title":"Association of single nucleotide polymorphisms (SNPs) in VEGF pathway genes with progression-free survival (PFS) and blood pressure (BP) in metastatic renal cell carcinoma (mRCC) in the Phase 3 trial of axitinib versus sorafenib (AXIS trial) cell carcinoma (mRCC) in the Phase 3 trial of axitinib versus sorafenib (AXIS trial).","volume":"47","author":"Escudier B","year":"2011","unstructured":"Escudier B , LoomisAK, KaprinA et al. Association of single nucleotide polymorphisms (SNPs) in VEGF pathway genes with progression-free survival (PFS) and blood pressure (BP) in metastatic renal cell carcinoma (mRCC) in the Phase 3 trial of axitinib versus sorafenib (AXIS trial) cell carcinoma (mRCC) in the Phase 3 trial of axitinib versus sorafenib (AXIS trial). Eur. J. Cancer 47(Suppl. 1) , S7505 (2011) (Abstract 7103).","journal-title":"Eur. J. Cancer"},{"key":"e_1_3_2_3_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1171-8"},{"key":"e_1_3_2_3_82_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066838"},{"key":"e_1_3_2_3_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr511"},{"key":"e_1_3_2_3_84_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37539"},{"key":"e_1_3_2_3_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2009.01198.x"},{"key":"e_1_3_2_3_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31820ae4ac"},{"key":"e_1_3_2_3_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.723"},{"key":"e_1_3_2_3_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr551"},{"key":"e_1_3_2_3_89_1","article-title":"Association of genetic markers in angiogenesis- or exposure-related genes with overall survival in pazopanib (P) treated patients (Pts) with advanced renal cell carcinoma.","volume":"29","author":"Xu C","year":"2011","unstructured":"Xu C , BallHA, BingN et al. Association of genetic markers in angiogenesis- or exposure-related genes with overall survival in pazopanib (P) treated patients (Pts) with advanced renal cell carcinoma. J. Clin. Oncol. 29(Suppl. 7) , Abstract 303 (2011).","journal-title":"J. Clin. Oncol."},{"key":"e_1_3_2_4_2_1","unstructured":"International HapMap Project. www.hapmap.org"},{"key":"e_1_3_2_4_3_1","unstructured":"The 1000 Genomes Project. www.1000genomes.org"},{"key":"e_1_3_2_4_4_1","unstructured":"European Collaborative Project EuroTARGET. www.eurotargetproject.eu"}],"container-title":["Pharmacogenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/pgs.12.142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T22:25:22Z","timestamp":1715984722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/pgs.12.142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":92,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.2217\/pgs.12.142"],"URL":"https:\/\/doi.org\/10.2217\/pgs.12.142","relation":{},"ISSN":["1462-2416","1744-8042"],"issn-type":[{"value":"1462-2416","type":"print"},{"value":"1744-8042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}