{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:03:12Z","timestamp":1768644192528,"version":"3.49.0"},"reference-count":88,"publisher":"Informa UK Limited","issue":"8","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Pharmacogenomics"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.2217\/pgs.15.29","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T16:26:14Z","timestamp":1434126374000},"page":"891-903","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":40,"title":["Update on Thiopurine Pharmacogenetics in Inflammatory Bowel Disease"],"prefix":"10.1080","volume":"16","author":[{"given":"Rebecca L","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Dunedin School of Medicine, PO Box 56, Dunedin, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray L","family":"Barclay","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Otago Christchurch, PO Box 4345, Christchurch, New Zealand"},{"name":"Department of Gastroenterology, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2015,6,12]]},"reference":[{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.09.001"},{"key":"e_1_3_2_4_1","article-title":"Azathioprine for maintaining remission of Crohn\u2019s disease","volume":"2","author":"Pearson DC","year":"2000","unstructured":"Pearson DC , MayGR , FickG , SutherlandLR . Azathioprine for maintaining remission of Crohn\u2019s disease . Cochrane Database Syst. Rev.2 , CD000067 ( 2000 ).","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000478.pub3"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07220.x"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.926"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06472.x"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32420"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.320"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.032"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70354-4"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-9-199811010-00007"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01177.x"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.8.1081"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01690.x"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200006000-00011"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200208000-00003"},{"issue":"5","key":"e_1_3_2_19_1","first-page":"651","article-title":"Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity","volume":"32","author":"Weinshilboum RM","year":"1980","unstructured":"Weinshilboum RM , SladekSL . Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity . Am. J. Hum. Genet.32 ( 5 ), 651 \u2013 662 ( 1980 ).","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0310-8"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3060"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6790"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200403000-00006"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20004"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31828b2866"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.053157"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500421"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283449200"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31828828d3"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3093"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32835f1cc0"},{"key":"e_1_3_2_32_1","unstructured":"TPMT nomenclature committee . www.imh.liu.se\/tpmtalleles ."},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000114745.08559.db"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000174788.69991.6b"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502352102"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199902000-00006"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181d6baf5"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05917.x"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.363010"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104833200"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100380200018"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0248-y"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00521144"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(75)93685-1"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(79)90410-8"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-002-0798-z"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1139\/o76-121"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100380200095"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03421.x"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200411000-00010"},{"issue":"11","key":"e_1_3_2_51_1","first-page":"1664","article-title":"ITPA genotyping is not predictive for the development of side effects in AZA treated inflammatory bowel disease patients","volume":"54","author":"van Dieren JM","year":"2005","unstructured":"van Dieren JM , van VuurenAJ , KustersJG , NieuwenhuisEE , KuipersEJ , van der WoudeCJ . ITPA genotyping is not predictive for the development of side effects in AZA treated inflammatory bowel disease patients . Gut54 ( 11 ), 1664 ( 2005 ).","journal-title":"Gut"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2005.10.019"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.055947"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02853.x"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2307-1"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e31821a7c34"},{"issue":"3","key":"e_1_3_2_57_1","first-page":"247","article-title":"A pharmacogenetics study of TPMT and ITPA genes detects a relationship with side effects and clinical response in patients with inflammatory bowel disease receiving Azathioprine","volume":"20","author":"Zabala-Fernandez W","year":"2011","unstructured":"Zabala-Fernandez W , Barreiro-de AcostaM , EcharriAet al. A pharmacogenetics study of TPMT and ITPA genes detects a relationship with side effects and clinical response in patients with inflammatory bowel disease receiving Azathioprine . J. Gastrointest. Liver Dis.20 ( 3 ), 247 \u2013 253 ( 2011 ).","journal-title":"J. Gastrointest. Liver Dis."},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03412.x"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.057158"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.074930"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03788.x"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(76)90044-7"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.025288"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.6.3517"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27599"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200111000-00004"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj037"},{"issue":"3","key":"e_1_3_2_68_1","first-page":"593","article-title":"The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: a case\u2013control study in the Portuguese population","volume":"22","author":"Silva SN","year":"2009","unstructured":"Silva SN , AzevedoAP , TeixeiraV , PinaJE , RueffJ , GasparJF . The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: a case\u2013control study in the Portuguese population . Oncol. Rep.22 ( 3 ), 593 \u2013 598 ( 2009 ).","journal-title":"Oncol. Rep."},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200402000-00005"},{"issue":"4","key":"e_1_3_2_70_1","first-page":"192","article-title":"Impaired metabolism of azathioprine in carbon tetrachloride-injured rats","volume":"28","author":"Hobara N","year":"1981","unstructured":"Hobara N , WatanabeA . Impaired metabolism of azathioprine in carbon tetrachloride-injured rats . Hepatogastroenterology28 ( 4 ), 192 \u2013 194 ( 1981 ).","journal-title":"Hepatogastroenterology"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i13.3534"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400959"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006413"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00196-9"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3078"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00465.2004"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0492556"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/01213011-199910000-00011"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds302"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.8.15770"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.4.485"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01353.x"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00127-2"},{"issue":"1","key":"e_1_3_2_84_1","first-page":"S30","article-title":"Clinical use and practical application of TPMT enzyme and 6-mercaptopurine metabolite monitoring in IBD","volume":"3","author":"Seidman EG","year":"2003","unstructured":"Seidman EG . Clinical use and practical application of TPMT enzyme and 6-mercaptopurine metabolite monitoring in IBD . Rev. Gastroenterol. Disord.3 ( Suppl. 1 ), S30 \u2013 S38 ( 2003 ).","journal-title":"Rev. Gastroenterol. Disord."},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05084.x"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056989"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095080"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.1.640"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.6384"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e318281f28f"}],"container-title":["Pharmacogenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/pgs.15.29","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T13:36:55Z","timestamp":1715953015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/pgs.15.29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":88,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.2217\/pgs.15.29"],"URL":"https:\/\/doi.org\/10.2217\/pgs.15.29","relation":{},"ISSN":["1462-2416","1744-8042"],"issn-type":[{"value":"1462-2416","type":"print"},{"value":"1744-8042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipgs20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipgs20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2015-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}