{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:56:51Z","timestamp":1760785011791,"version":"3.40.5"},"reference-count":82,"publisher":"Informa UK Limited","issue":"6","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Per. Med."],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.2217\/pme-2021-0031","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T09:13:59Z","timestamp":1634894039000},"page":"613-627","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["A Personalized Approach to Pancreatic Ductal Adenocarcinoma and its Application in Surgical Practice"],"prefix":"10.1080","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7046-0112","authenticated-orcid":false,"given":"Dimitrios","family":"Schizas","sequence":"first","affiliation":[{"name":"First Department of Surgery, National &amp; Kapodistrian University of Athens, Laikon General Hospital, Athens, 11527, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-1783","authenticated-orcid":false,"given":"Alkmini","family":"Koumpoura","sequence":"additional","affiliation":[{"name":"First Department of Surgery, National &amp; Kapodistrian University of Athens, Laikon General Hospital, Athens, 11527, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5907-6216","authenticated-orcid":false,"given":"Meropi","family":"Galari","sequence":"additional","affiliation":[{"name":"First Department of Surgery, National &amp; Kapodistrian University of Athens, Laikon General Hospital, Athens, 11527, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8871-3264","authenticated-orcid":false,"given":"Panagiota","family":"Economopoulou","sequence":"additional","affiliation":[{"name":"Oncology Unit, Second Propaideutic Department of Internal Medicine, National &amp; Kapodistrian University of Athens, Attikon University Hospital, Athens, 12462, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7357-6532","authenticated-orcid":false,"given":"Michail","family":"Vailas","sequence":"additional","affiliation":[{"name":"First Department of Surgery, National &amp; Kapodistrian University of Athens, Laikon General Hospital, Athens, 11527, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5628-137X","authenticated-orcid":false,"given":"Maria","family":"Sotiropoulou","sequence":"additional","affiliation":[{"name":"First Department of Surgery, National &amp; Kapodistrian University of Athens, Laikon General Hospital, Athens, 11527, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1466-7856","authenticated-orcid":false,"given":"Dimitrios","family":"Dimitroulis","sequence":"additional","affiliation":[{"name":"Second Propaedeutic Department of Surgery, National &amp; Kapodistrian University of Athens, Laikon General Hospital, Athens, 11527, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6221-6099","authenticated-orcid":false,"given":"Ioannis","family":"Maroulis","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Patras, University Hospital of Patras, Rio, 26504, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2988-4116","authenticated-orcid":false,"given":"Evangelos","family":"Felekouras","sequence":"additional","affiliation":[{"name":"First Department of Surgery, National &amp; Kapodistrian University of Athens, Laikon General Hospital, Athens, 11527, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15398285.2012.701177"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.04.030"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i31.10802"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.3019"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184504"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002223"},{"issue":"4","key":"e_1_3_3_10_1","first-page":"332","article-title":"Pancreatic cancer surgery: past, present, and future","volume":"27","author":"Griffin JF","year":"2015","unstructured":"Griffin JF , PorukKE , WolfgangCL. Pancreatic cancer surgery: past, present, and future. Chin. J. Cancer Res.27(4), 332\u2013348 (2015).","journal-title":"Chin. J. Cancer Res."},{"key":"e_1_3_3_11_1","unstructured":"NCCN Guidelines\n. Pancreatic Adenocarcinoma (Version 3.2019) (2019). http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/pancreatic.pdf"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2016.0003"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091427"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.11.040"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001383"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2018.02.002"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5072"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133149"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001092"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1008-0"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5043"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2016.01.003"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240527"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012418-012818"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.4081\/oncol.2019.410"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.418"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001744"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0479-5"},{"issue":"2","key":"e_1_3_3_29_1","first-page":"115","article-title":"Gene-by-environment interactions in pancreatic cancer: implications for prevention","volume":"88","author":"Jansen RJ","year":"2015","unstructured":"Jansen RJ , TanXL , PetersenGM. Gene-by-environment interactions in pancreatic cancer: implications for prevention. Yale J. Biol. Med.88(2), 115\u2013126 (2015).","journal-title":"Yale J. Biol. Med."},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2013.12.002"},{"key":"e_1_3_3_31_1","unstructured":"Gonzalez RS\n. WHO classification. PathologyOutlines.com (2019). www.pathologyoutlines.com\/topic\/pancreaswho.html"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41064"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2018.1453168"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164368"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2344"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16965"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3398"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14169"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.07.007"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4546-8"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2540-6"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-13-S2-S5"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000787"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0739-z"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10772"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11040497"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.02.001"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.10.024"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25459"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.09.14"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00040-6"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32557-1"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.09.030"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000867"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4632-8"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00245"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.5742"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003301"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2018.05.001"},{"issue":"5","key":"e_1_3_3_61_1","first-page":"497","article-title":"Multi-institutional experience with FOLFIRINOX in pancreatic adenocarcinoma","volume":"13","author":"Peddi PF","year":"2012","unstructured":"Peddi PF , LubnerS , McwilliamsRet al. Multi-institutional experience with FOLFIRINOX in pancreatic adenocarcinoma. JOP13(5), 497\u2013501 (2012).","journal-title":"JOP"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003468"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001850"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.648"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.209"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.07.007"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30327-9"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.4505"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02274"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3486-z"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz073"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)00172-8"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000378"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyy190"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-014-0737-7"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000251"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2211-4"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000267"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12295"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30175-X"},{"issue":"3","key":"e_1_3_3_81_1","first-page":"161","article-title":"Significance of precision medicine in pancreatic cancer prevention and treatment","volume":"38","author":"Wang CF","year":"2016","unstructured":"Wang CF . Significance of precision medicine in pancreatic cancer prevention and treatment. Zhonghua Zhong Liu Za Zhi38(3), 161\u2013164 (2016).","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002957"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-0426"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2019.08.007"}],"container-title":["Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/pme-2021-0031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T21:05:31Z","timestamp":1715979931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/pme-2021-0031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":82,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.2217\/pme-2021-0031"],"URL":"https:\/\/doi.org\/10.2217\/pme-2021-0031","relation":{},"ISSN":["1741-0541","1744-828X"],"issn-type":[{"type":"print","value":"1741-0541"},{"type":"electronic","value":"1744-828X"}],"subject":[],"published":{"date-parts":[[2021,10,22]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipme20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ipme20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}