{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:21:44Z","timestamp":1773231704404,"version":"3.50.1"},"reference-count":59,"publisher":"Informa UK Limited","issue":"9","funder":[{"name":"C\u00e1tedra de Investigaci\u00f3n Fundaci\u00f3n Jim\u00e9nez D\u00edaz de Medicina Regenerativa y Bioingenier\u00eda Tisular","award":["IIS-FJD-CIEMAT-UC3M"],"award-info":[{"award-number":["IIS-FJD-CIEMAT-UC3M"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["SAF2017-86810-R"],"award-info":[{"award-number":["SAF2017-86810-R"]}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["AvanCell-CM S2017\/BMD-3692"],"award-info":[{"award-number":["AvanCell-CM S2017\/BMD-3692"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Regen. Med."],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.2217\/rme-2020-0139","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T06:26:51Z","timestamp":1606458411000},"page":"2053-2065","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["Combined Adipose Mesenchymal Stromal Cell Advanced Therapy Resolved a Recalcitrant Leg Ulcer in an 85-Year-Old Patient"],"prefix":"10.1080","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-2364","authenticated-orcid":false,"given":"Luc\u00eda","family":"Mart\u00ednez-Santamar\u00eda","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Carlos III University (UC3M)","place":["Madrid, Spain"]},{"name":"Centre for Biomedical Network Research on Rare Diseases (CIBERER)","place":["Madrid, Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria de la Fundaci\u00f3n Jim\u00e9nez D\u00edaz","place":["Madrid, Spain"]},{"name":"Centre for Energy, Environment & Technology Research (CIEMAT)","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7400-6921","authenticated-orcid":false,"given":"Carmen","family":"C\u00e1rcamo","sequence":"additional","affiliation":[{"name":"Plastic & Reconstructive Surgery Department, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3382-8608","authenticated-orcid":false,"given":"Lourdes","family":"Garc\u00eda-Pardo","sequence":"additional","affiliation":[{"name":"Plastic & Reconstructive Surgery Department, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6266-9055","authenticated-orcid":false,"given":"Mariano","family":"Garc\u00eda-Arranz","sequence":"additional","affiliation":[{"name":"New Therapy Unit, Instituto de Investigaci\u00f3n Sanitaria de la Fundaci\u00f3n Jim\u00e9nez D\u00edaz & Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]},{"name":"Department of Surgery, Medicine School, Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9743-8903","authenticated-orcid":false,"given":"Gustavo","family":"Melen","sequence":"additional","affiliation":[{"name":"Production\u00a0Unit of Advanced Therapies Medicines, Fundaci\u00f3n para la Investigaci\u00f3n Biom\u00e9dica del Hospital Infantil Universitario Ni\u00f1o Jes\u00fas","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9927-2510","authenticated-orcid":false,"given":"Sara","family":"Guerrero-Aspizua","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Carlos III University (UC3M)","place":["Madrid, Spain"]},{"name":"Centre for Biomedical Network Research on Rare Diseases (CIBERER)","place":["Madrid, Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria de la Fundaci\u00f3n Jim\u00e9nez D\u00edaz","place":["Madrid, Spain"]},{"name":"Centre for Energy, Environment & Technology Research (CIEMAT)","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3443-7182","authenticated-orcid":false,"given":"Luc\u00eda","family":"Llanos","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Instituto de Investigaci\u00f3n Sanitaria de la Fundaci\u00f3n Jim\u00e9nez D\u00edaz","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-7189","authenticated-orcid":false,"given":"Marcela del","family":"R\u00edo","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Carlos III University (UC3M)","place":["Madrid, Spain"]},{"name":"Centre for Biomedical Network Research on Rare Diseases (CIBERER)","place":["Madrid, Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria de la Fundaci\u00f3n Jim\u00e9nez D\u00edaz","place":["Madrid, Spain"]},{"name":"Centre for Energy, Environment & Technology Research (CIEMAT)","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-2338","authenticated-orcid":false,"given":"Dami\u00e1n","family":"Garc\u00eda-Olmo","sequence":"additional","affiliation":[{"name":"New Therapy Unit, Instituto de Investigaci\u00f3n Sanitaria de la Fundaci\u00f3n Jim\u00e9nez D\u00edaz & Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]},{"name":"Department of Surgery, Medicine School, Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5434-1885","authenticated-orcid":false,"given":"Mar\u00eda-Jos\u00e9","family":"Esc\u00e1mez","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Carlos III University (UC3M)","place":["Madrid, Spain"]},{"name":"Centre for Biomedical Network Research on Rare Diseases (CIBERER)","place":["Madrid, Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria de la Fundaci\u00f3n Jim\u00e9nez D\u00edaz","place":["Madrid, Spain"]},{"name":"Centre for Energy, Environment & Technology Research (CIEMAT)","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13954"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13281"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-017-0081-y"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00773"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12683"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040789"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122083"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1730296"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X13666180913123424"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEB.2019.0351"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27922"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102523"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12712"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-1044-5"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8070917"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01645"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba6884"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0627"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27737-y"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734619880055"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(98)00107-7"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000112381.80964.85"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-004-7253-4"},{"key":"e_1_3_5_26_1","first-page":"924","article-title":"Treatment of diabetic foot trophic lesions using a tissue-engineered dermal graft","volume":"14","author":"Llames S","year":"2008","unstructured":"LlamesS , Garcia-PerezE , GarciaVet al.Treatment of diabetic foot trophic lesions using a tissue-engineered dermal graft. Tissue Eng. Part A14, 924 (2008).","journal-title":"Tissue Eng. Part A"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/10430340252939069"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12097"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM01377B"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2879"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0052-6"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181973487"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-012-1581-9"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0238-3"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19-0091"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2018.09.003"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2013.02.006"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1934-z"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02344811"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.07.005"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-018-1877-5"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2541275"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689717721221"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03600-0"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/10763270260424141"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/961758"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.12.020"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19-0271"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01855-9"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00697"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020445"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197038"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0226"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001886"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041306"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0007"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.09.041"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1133"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2012.0665"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme.13.80"},{"issue":"6","key":"e_1_3_5_61_1","first-page":"2652","article-title":"Allogeneic fibroblast sheets accelerate cutaneous wound healing equivalent to autologous fibroblast sheets in mice","volume":"12","author":"Nagase T","year":"2020","unstructured":"NagaseT , UenoK , MizoguchiTet al.Allogeneic fibroblast sheets accelerate cutaneous wound healing equivalent to autologous fibroblast sheets in mice. Am. J. Transl. Res.12(6), 2652\u20132663 (2020).","journal-title":"Am. J. Transl. Res."}],"container-title":["Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/rme-2020-0139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:38:07Z","timestamp":1773157087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/rme-2020-0139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.2217\/rme-2020-0139"],"URL":"https:\/\/doi.org\/10.2217\/rme-2020-0139","relation":{},"ISSN":["1746-0751","1746-076X"],"issn-type":[{"value":"1746-0751","type":"print"},{"value":"1746-076X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=irme20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=irme20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}