{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:22:05Z","timestamp":1782516125928,"version":"3.54.5"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p> Aim: Evaluate efficacy\/safety of bremelanotide (BMT), a melanocortin-receptor-4 agonist, to treat female sexual dysfunctions in premenopausal women. Methods: Patients randomized to receive placebo or BMT 0.75, 1.25 or 1.75 mg self-administered subcutaneously, as desired, over 12 weeks. Primary end point was change in satisfying sexual events\/month. Secondary end points included total score changes on female sexual function index and female sexual distress scale-desire\/arousal\/orgasm. Results: Efficacy data, n = 327. For 1.25\/1.75-mg pooled versus placebo, mean changes from baseline to study end were +0.7 versus +0.2 satisfying sexual events\/month (p = 0.0180), +3.6 versus +1.9 female sexual function index total score (p = 0.0017), \u221211.1 versus \u22126.8 female sexual distress scale-desire\/arousal\/orgasm total score (p = 0.0014). Adverse events: nausea, flushing, headache. Conclusion: In premenopausal women with female sexual dysfunctions, self-administered, as desired, subcutaneous BMT was safe, effective, and well tolerated (NCT01382719). <\/jats:p>","DOI":"10.2217\/whe-2016-0018","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T12:21:20Z","timestamp":1533126080000},"page":"325-337","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":68,"title":["Bremelanotide for Female Sexual Dysfunctions in Premenopausal Women: A Randomized, Placebo-Controlled Dose-Finding Trial"],"prefix":"10.1177","volume":"12","author":[{"given":"Anita H","family":"Clayton","sequence":"first","affiliation":[{"name":"University of Virginia, 2955 Ivy Road, Northridge Suite 210, Charlottesville, VA 22903, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley E","family":"Althof","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine, 1100 Euclid Avenue, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl","family":"Kingsberg","sequence":"additional","affiliation":[{"name":"University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard R","family":"DeRogatis","sequence":"additional","affiliation":[{"name":"Maryland Center for Sexual Health, 1300 York Road, Lutherville, MD 21093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Kroll","sequence":"additional","affiliation":[{"name":"Seattle Women's Health, Research, Gynecology, 3216 NE 45th Place, Seattle, WA 98105, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin","family":"Goldstein","sequence":"additional","affiliation":[{"name":"San Diego Sexual Medicine\/Alvarado Hospital & Medical Center, 6655 Alvarado Road, San Diego, CA 92120, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jed","family":"Kaminetsky","sequence":"additional","affiliation":[{"name":"Manhattan Medical Research, 215 Lexington Avenue, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Spana","sequence":"additional","affiliation":[{"name":"Palatin Technologies, Inc., 4C Cedar Brook Drive, Cranbury, NJ 08512, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johna","family":"Lucas","sequence":"additional","affiliation":[{"name":"Palatin Technologies, Inc., 4C Cedar Brook Drive, Cranbury, NJ 08512, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jordan","sequence":"additional","affiliation":[{"name":"Palatin Technologies, Inc., 4C Cedar Brook Drive, Cranbury, NJ 08512, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Portman","sequence":"additional","affiliation":[{"name":"Columbus Center for Women's Health Research, 99 North Brice Road, Columbus, OH 43213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,6,1]]},"reference":[{"key":"bibr1a-whe-2016-0018","volume-title":"Papers of special note have been highlighted as: \u2022 of interest; 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