{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:07:28Z","timestamp":1776859648193,"version":"3.51.2"},"reference-count":113,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p> Uterine leiomyomas are present in 30\u201370% of women of reproductive age. In addition to causing menstrual disorders and pain, uterine fibroids negatively affect fertility and pregnancy outcome for patients pursuing assisted reproduction. The two questions that have to be addressed are: which fibroids should be treated and how should they be treated? Submucosal fibroids are associated with a 70% reduction in delivery rate. Intramural fibroids had a lesser effect and reduced the delivery rate by approximately 30%. By contrast, studies have demonstrated that subserosal fibroids did not negatively impact fertility. Furthermore, both submucosal and intramural fibroids were associated with an increased risk of spontaneous miscarriage. Myomectomy is considered the treatment of choice to alleviate these detrimental effects. Further research is needed before alternative treatments can be recommended. <\/jats:p>","DOI":"10.2217\/whe.09.29","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T09:09:58Z","timestamp":1265188198000},"page":"413-421","source":"Crossref","is-referenced-by-count":30,"title":["Management of Uterine Fibroids in the Patient Pursuing Assisted Reproductive Technologies"],"prefix":"10.1177","volume":"5","author":[{"given":"Mohammad","family":"Ezzati","sequence":"first","affiliation":[{"name":"Mohammad Ezzati, MD, Department of Obstetrics & Gynecology, Washington Hospital Center, Washington, DC, USA, Tel.: +1 202 877 8035, Fax: +1 202 877 5435,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M","family":"Norian","sequence":"additional","affiliation":[{"name":"John M Norian, MD, Reproductive Biology & Medicine Branch, NICHD, NIH, Building 10, CRC, 1 East, Room 1-3140, 10 Center Drive, Bethesda, MD 20892, USA, Tel.: +1 301 496 5800, Fax: +1 301 402 0884,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H","family":"Segars","sequence":"additional","affiliation":[{"name":"James H Segars, MD, Reproductive Biology & Medicine Branch, NICHD, NIH, Building 10, CRC, 1 East, Room 1-3140, 10 Center Drive, Bethesda, MD 20892, USA, Tel.: +1 301 496 5800, Fax: +1 301 402 0884,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,7,1]]},"reference":[{"key":"bibr00101-WHE.09.29","unstructured":"Papers of special note have been highlighted as:"},{"key":"bibr00102-WHE.09.29","unstructured":"of interest"},{"key":"bibr00103-WHE.09.29","unstructured":"of considerable interest"},{"key":"bibr1-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/94.4.435"},{"key":"bibr0105-WHE.09.29","unstructured":"An original paper including histological evaluation of fibroids in hysterectomy specimens."},{"key":"bibr2-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00534-6"},{"key":"bibr3-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.99"},{"key":"bibr0108-WHE.09.29","unstructured":"Large sample study investigating the effects of race on fibroid incidence."},{"key":"bibr4-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh407"},{"key":"bibr5-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2005.12.004"},{"key":"bibr6-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)02207-6"},{"key":"bibr7-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112063"},{"key":"bibr01013-WHE.09.29","unstructured":"Excellent review outlining the general burden caused by uterine fibroids."},{"key":"bibr8-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/6.6.614"},{"key":"bibr01015-WHE.09.29","unstructured":"Comprehensive review of early studies evaluating the effects of fibroids on reproductive outcome."},{"key":"bibr9-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200108000-00022"},{"key":"bibr01017-WHE.09.29","unstructured":"Meta-analyses and structured review of the existing studies of the effects of fibroids on fertility."},{"key":"bibr10-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.012"},{"key":"bibr11-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1159\/000084513"},{"key":"bibr100-WHE.09.29","unstructured":"Meta-analyses and structured review of the existing studies of the effects of fibroids on fertility."},{"key":"bibr12-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm013"},{"key":"bibr01022-WHE.09.29","unstructured":"Meta-analyses and structured review of the existing studies of the effects of fibroids on fertility."},{"key":"bibr13-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.12.039"},{"key":"bibr14-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.01.051"},{"key":"bibr01025-WHE.09.29","unstructured":"Meta-analyses and structured review of the existing studies of the effects of fibroids on fertility."},{"key":"bibr15-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b126"},{"key":"bibr16-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2005.12.008"},{"key":"bibr17-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2008.01.009"},{"key":"bibr18-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60536-6"},{"key":"bibr19-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03807.x"},{"key":"bibr20-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.09.015"},{"key":"bibr21-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.09.069"},{"key":"bibr22-WHE.09.29","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90194-4"},{"key":"bibr23-WHE.09.29","first-page":"41","volume":"75","author":"Davis JL","year":"1990","journal-title":"Obstet. 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