{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:57:12Z","timestamp":1781881032239,"version":"3.54.5"},"reference-count":67,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:p> For decades, hormone-replacement therapy (HRT) was considered safe and was the first choice in prevention of postmenopausal osteoporosis induced by estrogen deficiency. Numerous experimental and epidemiological studies further supported a protective effect of exogenous female sex hormones on atherogenesis and coronary heart disease (CHD) in women after the menopause. However, the fact that these promising results were not translated into lower incidences of CHD events in hormone-treated women compared with placebo in subsequent, large, randomized studies of healthy subjects as well as women with known CHD raised a very intense debate concerning the safety of HRT in terms of cardiovascular risk. A critical mass of data points toward a protective influence of HRT on cardiovascular disease end points in early postmenopausal women, but increased harm in elderly women, especially those with abdominal adiposity or metabolic syndrome. Once the quasi-hysterical reaction to the largest of the randomized studies (the Women's Health Initiative) has abated, a future strategy should be to concentrate on identifying those relatively few individuals who are not suitable for HRT, as HRT still remains the most thoroughly investigated pharmacological prevention strategy of osteoporosis. <\/jats:p>","DOI":"10.2217\/whe.09.52","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T09:09:58Z","timestamp":1265188198000},"page":"637-647","source":"Crossref","is-referenced-by-count":11,"title":["Long-Term Prevention with Hormone-Replacement Therapy after the Menopause: Which Women should be Targeted?"],"prefix":"10.1177","volume":"5","author":[{"given":"Peter","family":"Alexandersen","sequence":"first","affiliation":[{"name":"Peter Alexandersen, Center for Clinical & Basic Research a\/s, Ballerup Byvej 222, DK-2750 Ballerup, Denmark, Tel.: +45 44 684 600, Fax: +45 44 684 220,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten A","family":"Karsdal","sequence":"additional","affiliation":[{"name":"Morten A Karsdal, Nordic Bioscience a\/s, Herlev Hovedgade 207, 2730 Herlev, Denmark, Tel.: +45 44 525 252, Fax: +45 44 535 251,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Claus Christiansen, Nordic Bioscience a\/s, Herlev Hovedgade 207, 2730 Herlev, Denmark, Tel.: +45 44 525 252, Fax: +45 44 535 251,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,11,1]]},"reference":[{"key":"bibr0101-WHE.09.52","unstructured":"Papers of special note have been highlighted as:"},{"key":"bibr0102-WHE.09.52","unstructured":"of interest"},{"key":"bibr0103-WHE.09.52","unstructured":"of considerable interest"},{"key":"bibr1-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1508"},{"key":"bibr2-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-200301000-00008"},{"key":"bibr3-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1702-6"},{"key":"bibr4-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"bibr0108-WHE.09.52","unstructured":"Initial report on the results of the Women's Health Initiative (WHI) study, the largest randomized, placebocontrolled study ever undertaken on combined estrogen plus progestin on cardiovascular outcomes. The design and the results of this study have stimulated an intense debate for many years after its publication, but this study was conducted in a population of woman substantially older than those for whom hormone-replacement therapy (HRT) is normally prescribed for symptom relief."},{"key":"bibr5-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050061"},{"key":"bibr6-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256280"},{"key":"bibr7-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050224"},{"key":"bibr8-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.03.048"},{"key":"bibr9-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2006.05.011"},{"key":"bibr10-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070007"},{"issue":"3","key":"bibr11-WHE.09.52","first-page":"155","volume":"4","author":"Delmas PD","year":"1999","journal-title":"J. Epidemiol. 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Results differ from those of the combined estrogen plus progestin trial on several important points."},{"key":"bibr26-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.13.1465"},{"key":"bibr01033-WHE.09.52","unstructured":"Post hoc analysis of the WHI showing the importance of years since menopause for the cardiovascular benefit\/harm ratio of HRT."},{"key":"bibr27-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39266.425069.AD"},{"key":"bibr28-WHE.09.52","first-page":"CD004143","volume":"2","author":"Farquhar C","year":"2009","journal-title":"Cochrane Database Syst. 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HRT was associated with significantly less all-cause and cardiovascular mortality as well as aortic calcification."},{"key":"bibr41-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.8.980"},{"key":"bibr01051-WHE.09.52","unstructured":"Follow-up analysis on the WHI study reported that the cardiovascular events that related to HRT occurred in women with elevated metabolic risk at baseline despite being clinically healthy."},{"key":"bibr42-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1080\/13697130500042417"},{"issue":"23","key":"bibr43-WHE.09.52","first-page":"III27","volume":"109","author":"Davignon J","year":"2004","journal-title":"Circulation"},{"key":"bibr44-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.10.6.1051"},{"key":"bibr45-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(03)00123-5"},{"key":"bibr46-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000131262.98040.65"},{"key":"bibr47-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.018"},{"key":"bibr48-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2005.02.016"},{"key":"bibr01059-WHE.09.52","unstructured":"Excellent interpretation of the HRT effects observed in epidemiological and clinical studies based on results obtained from his groups' many experimental studies in cynomolgus monkeys."},{"key":"bibr49-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00319-1"},{"key":"bibr50-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2008.02.008"},{"key":"bibr51-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2009.01.1949"},{"key":"bibr52-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2005.02.019"},{"key":"bibr01064-WHE.09.52","unstructured":"European Menopause and Andropause Society statement following the WHI results from 2002."},{"key":"bibr53-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.8.1042"},{"key":"bibr01066-WHE.09.52","unstructured":"Well-conducted study showing the efficacy and safety of an unopposed, ultra-low-dose of estogen daily in women with an intact uterus."},{"key":"bibr54-WHE.09.52","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000137833.43248.79"}],"container-title":["Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2217\/WHE.09.52","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2217\/WHE.09.52","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2217\/WHE.09.52","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T10:28:32Z","timestamp":1741688912000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2217\/WHE.09.52"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.2217\/WHE.09.52"],"URL":"https:\/\/doi.org\/10.2217\/whe.09.52","relation":{},"ISSN":["1745-5057","1745-5065"],"issn-type":[{"value":"1745-5057","type":"print"},{"value":"1745-5065","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}