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We propose changing T to specify exact tumor size (a tumor of pathological diameter 1.7 cm would be pT1.7); changing N to specify the number of metastatic lymph nodes over the total number removed (e.g., pN5\/21); adding suffixes to M to indicate metastatic site; removing in situ neoplasms from the classification, since they are not carcinomas and are incapable of metastasizing; and removing the terms \u2018infiltrating\u2019 and \u2018invasive\u2019 since they are redundant. Finally, we would include hormone receptor, HER2, and other biological indicators of prognosis, as they are verified, in a placeholder system appended to the TNM. These proposals shift the emphasis from the quantity of tumor present to the quality of the cancer. <\/jats:p>","DOI":"10.2217\/whe.10.82","type":"journal-article","created":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T12:02:07Z","timestamp":1293105727000},"page":"41-49","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A New TNM Classification for Breast Cancer to Meet the Demands of the Present and the Challenges of the Future"],"prefix":"10.1177","volume":"7","author":[{"given":"Stefano","family":"Zurrida","sequence":"first","affiliation":[{"name":"Senology Department, Istituto Europeo di Oncologia, Via Ripamonti 435, 20141 Milan, Italy"},{"name":"University of Milan, School of Medicine, Via Festa del Perdono, 7, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Veronesi","sequence":"additional","affiliation":[{"name":"Scientific Director, Istituto Europeo di Oncologia, Via Ripamonti 435, 20141 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"issue":"15","key":"bibr1-WHE.10.82","first-page":"415","volume":"85","author":"Denoix PF","year":"1959","journal-title":"Mem. 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