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A recently launched combination of ethinylestradiol 20 \u03bcg and drospirenone 3 mg demonstrates the advantages of a lower estrogen dose with the antimineralocorticoid activity of drospirenone that is responsible for the drug's significant antiandrogenic and antimineralocorticoid effects, reflected clinically in lower rates of adverse events including less fluid retention. In addition to the drug's contraceptive efficacy, its effects on the skin and other classic noncontraceptive benefits, the ethinylestradiol 20 \u03bcg and drospirenone 3 mg combination has demonstrated highly satisfactory results in women with premenstrual dysphoric syndrome. <\/jats:p>","DOI":"10.2217\/whe.10.84","type":"journal-article","created":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T12:02:07Z","timestamp":1293105727000},"page":"19-30","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Drospirenone\/Ethinylestradiol: A Review on Efficacy and Noncontraceptive Benefits"],"prefix":"10.1177","volume":"7","author":[{"given":"Rog\u00e9rio Bonassi","family":"Machado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano de Melo","family":"Pompei","sequence":"additional","affiliation":[{"name":"Gynecological Endocrinology, Menopause & Family Planning Clinic, Department of Gynecology & Obstetrics, ABC School of Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ar\u00edcia Galv\u00e3o","family":"Giribela","sequence":"additional","affiliation":[{"name":"Family Planning Clinic, Teaching Hospital, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassiana Galv\u00e3o","family":"Giribela","sequence":"additional","affiliation":[{"name":"Family Planning Clinic, Teaching Hospital, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"key":"bibr1-WHE.10.84","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp030751"},{"key":"bibr2-WHE.10.84","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi046"},{"key":"bibr3-WHE.10.84","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2005.08.021"},{"key":"bibr4-WHE.10.84","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000175834.77215.2e"},{"key":"bibr5-WHE.10.84","doi-asserted-by":"publisher","DOI":"10.1080\/13625180008500407"},{"key":"bibr6-WHE.10.84","first-page":"281","volume-title":"Handbook of experimental Pharmacology.","author":"Kuhnz W","year":"1999"},{"issue":"1","key":"bibr7-WHE.10.84","first-page":"18","volume":"7","author":"Blode H","year":"2002","journal-title":"Gynaecol. 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