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There is widespread variation of practice in the management of hypertensive disease in pregnancy, which may lead to substandard care. The use of aspirin in preventing pre-eclampsia, the lack of correlation between urinary protein and adverse outcome, and the ineffectiveness of corticosteroids in the management of hemolysis and elevated liver enzymes and low platelets syndrome are a few of the developments that will alter the way this condition is managed. This article aims to provide a general overview of pre-eclampsia, eclampsia and hemolysis, hemolysis and elevated liver enzymes and low platelets syndrome supported by the latest evidence, which will help the care provider adopt a focused approach and use the latest knowledge to understand and manage this old condition. <\/jats:p>","DOI":"10.2217\/whe.11.57","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T15:53:47Z","timestamp":1314806027000},"page":"555-569","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Pre-Eclampsia, Severe Pre-Eclampsia and Hemolysis, Elevated Liver Enzymes and Low Platelets Syndrome: What is New?"],"prefix":"10.1177","volume":"7","author":[{"given":"Etienne","family":"Ciantar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Leeds Institute of Molecular Medicine, Level 8, Clinical Science Building, St James University Hospital, Beckett Street, Leeds, LS9 7TL, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"key":"bibr1a-WHE.11.57","unstructured":"Papers of special note have been highlighted as:"},{"key":"bibr1b-WHE.11.57","unstructured":"of interest"},{"key":"bibr2b-WHE.11.57","unstructured":"of considerable interest"},{"key":"bibr1-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"bibr2-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01423.x"},{"key":"bibr3-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90090-7"},{"key":"bibr4-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02800-2"},{"key":"bibr5-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2255"},{"key":"bibr6-WHE.11.57","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.1111\/j.1471-0528.2011.03104.x","volume":"118","author":"Draycott T","year":"2011","journal-title":"BJOG"},{"key":"bibr3b-WHE.11.57","unstructured":"Highlights the substandard care in the management of pre-eclampsia, mainly due to inadequate control of systolic blood pressure"},{"key":"bibr7-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a45b25"},{"key":"bibr8-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02507.x"},{"key":"bibr4b-WHE.11.57","unstructured":"Following from the Centre for Maternal and Child Enquiries report, this paper demonstrates the wide variation in the prevention and management of pre-eclampsia in the UK, emphasising the need for a national guideline"},{"volume-title":"Hypertension in Pregnancy: the Management of Hypertensive Disorders During Pregnancy.","year":"2010","author":"National Collaborating Centre for Women's and Children's Health.","key":"bibr9-WHE.11.57"},{"key":"bibr5b-WHE.11.57","unstructured":"The NICE guideline on the management of hypertensive disorders in pregnancy issued in August 2010, providing thorough evidence-based information on the appropriate management and reducing the risk of hypertensive disease in pregnancy as well as follow-up care"},{"key":"bibr10-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1991.tb13450.x"},{"key":"bibr11-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1038\/nri1897"},{"key":"bibr12-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(98)90054-6"},{"key":"bibr13-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2006.11.008"},{"key":"bibr14-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(80)90051-9"},{"key":"bibr15-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91199-0"},{"key":"bibr16-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)32330-4"},{"key":"bibr17-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70254-6"},{"key":"bibr18-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2000.0560"},{"key":"bibr19-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.066"},{"key":"bibr20-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031884"},{"key":"bibr21-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00820.x"},{"key":"bibr22-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055352"},{"key":"bibr23-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70341-8"},{"key":"bibr24-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.660134"},{"key":"bibr25-WHE.11.57","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(11)70020-2"},{"key":"bibr26-WHE.11.57","first-page":"CD004659","volume":"2","author":"Duley L","year":"2007","journal-title":"Cochrane Database Syst. 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