{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T04:27:46Z","timestamp":1741667266547,"version":"3.38.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p> Beyaz\u00ae (Bayer Healthcare Pharmaceuticals, Berlin, Germany) consists of 28 film-coated tablets: 24 tablets each containing 3 mg drospirenone plus 20 \u00b5g ethinylestradiol (EE) and 451 \u00b5g levomefolate calcium followed by four tablets, each containing 451 \u00b5g levomefolate calcium. It has the same indications of the parent compound 20 \u00b5g EE\/3 mg drospirenone in a 24\/4-day regimen (i.e., contraception, moderate acne, premenstrual dysforic disorder). In addition, the 24-day regimen with 20 \u00b5g EE\/3 mg drospirenone\/levomefolate calcium assure significant increases in red blood cell and plasma folate levels reaching values indicated to be protective in reducing the risk of neural tube defects. A progressive decrease in folate levels has been observed in women taking a 30 \u00b5g EE pill fortified with the same dose of levomefolate calcium upon discontinuation. At 4 and 8 weeks following cessation of the oral contraceptive, red blood cell folate levels &gt;906 nmol\/l were measured in 85 and 60% of women respectively. Because of this, the folate-containing pill may aid in reducing the risk of neural tube defects in a pregnancy conceived during use or shortly after the discontinuation of the product. <\/jats:p>","DOI":"10.2217\/whe.11.68","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T16:13:11Z","timestamp":1323965591000},"page":"13-19","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyaz\u00ae: An Oral Contraceptive Fortified with Folate"],"prefix":"10.1177","volume":"8","author":[{"given":"Franca","family":"Fruzzetti","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynecology, Santa Chiara Hospital, via Roma 35, 56100 Pisa, Italy, Tel.: +39 328 783 5816,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"bibr1-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(94)00015-O"},{"key":"bibr2-WHE.11.68","first-page":"13","volume":"3","author":"Foidart JM","year":"1995","journal-title":"Gynecol. Snapshot"},{"key":"bibr3-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(96)00195-3"},{"key":"bibr4-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2003.08.008"},{"key":"bibr5-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1080\/13625180008500376"},{"key":"bibr6-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(00)00133-5"},{"key":"bibr7-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.8.7.989"},{"key":"bibr8-WHE.11.68","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/14730782.2000.12288986","volume":"5","author":"Oelkers W","year":"2000","journal-title":"Eur. J. Contracept. Reprod. Health Care"},{"key":"bibr9-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2006.10.011"},{"key":"bibr10-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2007.05.080"},{"key":"bibr11-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1080\/13625180008500387"},{"key":"bibr12-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1080\/13625180008500375"},{"key":"bibr13-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000230348.05745.7d"},{"key":"bibr14-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.08.030"},{"key":"bibr15-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(00)00083-4"},{"key":"bibr16-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200626030-00004"},{"key":"bibr17-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.2165\/00024677-200605020-00005"},{"key":"bibr18-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1080\/ejc.8.1.37.51"},{"key":"bibr19-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2004.05.013"},{"key":"bibr20-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2009.03.013"},{"key":"bibr21-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2009.01.016"},{"key":"bibr22-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2006.02.006"},{"key":"bibr23-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2004.12.012"},{"key":"bibr24-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2008.44.2.1191057"},{"key":"bibr25-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(93)90024-F"},{"key":"bibr26-WHE.11.68","first-page":"729","volume":"53","author":"Rapkin AJ","year":"2008","journal-title":"J. Reprod. Med"},{"key":"bibr27-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000175834.77215.2e"},{"key":"bibr28-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767120-00007"},{"key":"bibr29-WHE.11.68","unstructured":"Maloney JM, Kunz M, Lee-Sugh S,  Drosperinone 3 mg\/ethinylestradiol 20 \u03bcg COC in the treatment of acne vulgaris: lesion count, ISGA. Presented at: 55th Annual Clinical Meeting of the American College of Obstetricians and Gynaecologists. San Diego, CA, USA, 5\u20139 May 2007."},{"key":"bibr30-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530210052030"},{"key":"bibr31-WHE.11.68","first-page":"703","volume":"86","author":"Kirke PN","year":"1993","journal-title":"Q. J. Med"},{"key":"bibr32-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.15.1867"},{"key":"bibr33-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1970.tb01447.x"},{"key":"bibr34-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90133-A"},{"key":"bibr35-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272602"},{"key":"bibr36-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03410210053035"},{"key":"bibr37-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412006"},{"key":"bibr38-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32227-7"},{"key":"bibr39-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2001123"},{"key":"bibr40-WHE.11.68","first-page":"180","volume":"94","author":"O'Leary M","year":"2001","journal-title":"Ir. Med. J"},{"issue":"243","key":"bibr41-WHE.11.68","first-page":"1","volume":"11","author":"Wright JD","year":"1998","journal-title":"Vital Health Stat"},{"key":"bibr42-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.23.2981"},{"key":"bibr43-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11994-5"},{"key":"bibr44-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30651"},{"volume-title":"Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B-6, Folate, Vitamin B-12, Pantothenic Acid, Biotin, and Choline","year":"1998","key":"bibr45-WHE.11.68"},{"key":"bibr46-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.3.473"},{"key":"bibr47-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.11.3353"},{"key":"bibr48-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.189"},{"key":"bibr49-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00492.x"},{"key":"bibr50-WHE.11.68","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.1.156"},{"key":"bibr51-WHE.11.68","volume":"18","author":"Pietrzik K","year":"2005","journal-title":"S. Afr. J. Clin. Nutr"},{"key":"bibr52-WHE.11.68","unstructured":"Marr AJ, Sampson-Landers C, Diefenbach K, Trummer D, Bart S, Blode H. Folate and homocysteine levels after 24 weeks administration of Yaz + levomefolate calcium 0.451 mg. Presented at: The 11th Congress of the European Society of Contraception and Reproductive Health. The Hague, The Netherlands, 19\u201322 May 2010 (Abstract P178)."},{"key":"bibr53-WHE.11.68","unstructured":"Diefenbach K, Trummer D, Ebert F, Lissy M, Rohde B, Blode H. Changes in folate levels following cessation of Yasmin and levomefolate calcium 0.451 mg or folic acid 400 meg co-administration. Presented at: The 11th Congress of the European Society of Contraception and Reproductive Health. The Hague, The Netherlands, 19\u201322 May 2010 (Abstract P176)."}],"container-title":["Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2217\/WHE.11.68","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2217\/WHE.11.68","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2217\/WHE.11.68","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T18:04:24Z","timestamp":1741629864000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2217\/WHE.11.68"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.2217\/WHE.11.68"],"URL":"https:\/\/doi.org\/10.2217\/whe.11.68","relation":{},"ISSN":["1745-5057","1745-5065"],"issn-type":[{"type":"print","value":"1745-5057"},{"type":"electronic","value":"1745-5065"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}