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For women with a history of a prior spontaneous preterm birth between 20 weeks and 36 weeks and 6 days of gestation, the use of 17-\u03b1 hydroxyprogesterone caproate has been shown to reduce the risk of recurrent preterm birth by more than 30%. This medication is the only Drug currently FDA approved for the prevention of preterm birth, and it is the first Drug the FDA has approved for use exclusively during pregnancy in approximately 15 years. <\/jats:p>","DOI":"10.2217\/whe.11.78","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T16:13:11Z","timestamp":1323965591000},"page":"21-30","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["17-\u03b1 Hydroxyprogesterone Caproate for the Prevention of Preterm Birth"],"prefix":"10.1177","volume":"8","author":[{"given":"Simi","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, NYU School of Medicine, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley S","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, NYU School of Medicine, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"bibr1a-WHE.11.78","unstructured":"Papers of special note have been highlighted as:"},{"key":"bibr2a-WHE.11.78","unstructured":"of interest."},{"key":"bibr3a-WHE.11.78","unstructured":"of considerable interest."},{"key":"bibr1-WHE.11.78","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3175"},{"key":"bibr2-WHE.11.78","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2001.00010.x"},{"key":"bibr3-WHE.11.78","volume-title":"Preterm Birth: Causes, Consequences and Prevention","author":"Behrman RE","year":"2007"},{"key":"bibr4-WHE.11.78","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70225-9"},{"key":"bibr5-WHE.11.78","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035140"},{"key":"bibr4a-WHE.11.78","unstructured":"Clinical Phase III trial that was the basis for US FDA approval of 17-\u03b1 hydroxyprogesterone caproate (17OHPC) for the prevention of recurrent singleton spontaneous preterm birth."},{"key":"bibr6-WHE.11.78","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31820eee00"},{"key":"bibr7-WHE.11.78","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181d4ffa5"},{"key":"bibr8-WHE.11.78","first-page":"CD004661","volume":"1","author":"Doyle LW","year":"2009","journal-title":"Cochrane Database Syst. 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