{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:30:43Z","timestamp":1789871443585,"version":"4.0.1"},"reference-count":106,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p> Women who inherit a mutation in either the BRCA1 or BRCA2 gene have greatly elevated lifetime risks of ovarian cancer, fallopian tube cancer and breast cancer. Preventive surgical removal of the ovaries and fallopian tubes (salpingo-oophorectomy) is recommended to these women, often prior to natural menopause, to prevent cancer. The ensuing hormone deprivation may impact on health and quality of life. Most of these women experience menopausal symptoms shortly after surgery; however, there may also be longer term consequences that are less well understood. In this review, we highlight recent studies that examine the implications of salpingo-oophorectomy on health and quality of life in BRCA-positive women and we discuss the care of women following prophylactic surgery. <\/jats:p>","DOI":"10.2217\/whe.12.41","type":"journal-article","created":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T09:15:31Z","timestamp":1346404531000},"page":"543-555","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["<i>BRCA<\/i> Carriers, Prophylactic Salpingo-Oophorectomy and Menopause: Clinical Management Considerations and Recommendations"],"prefix":"10.1177","volume":"8","author":[{"given":"Amy","family":"Finch","sequence":"first","affiliation":[{"name":"Women's College Research Institute, Women's College Hospital, 790 Bay Street, Suite 700, Toronto, ON, M5G 1N8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, The University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 0JH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A","family":"Narod","sequence":"additional","affiliation":[{"name":"Women's College Research Institute, Women's College Hospital, 790 Bay Street, Suite 700, Toronto, ON, M5G 1N8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,9,1]]},"reference":[{"key":"bibr1a-WHE.12.41","unstructured":"Papers of special note have been highlighted as:"},{"key":"bibr2a-WHE.12.41","unstructured":"of interest"},{"key":"bibr3a-WHE.12.41","unstructured":"of considerable interest"},{"key":"bibr1-WHE.12.41","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088759"},{"issue":"1","key":"bibr2-WHE.12.41","first-page":"265","volume":"56","author":"Easton DF","year":"1995","journal-title":"Am. 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