{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:51:08Z","timestamp":1777593068588,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p> Our hypothesis was that thrombosis occurring in postmenopausal women given testosterone (T) or testosterone\u2013estradiol (TE) to improve libido was associated with a prothrombotic interaction between T or TE with underlying inherited procoagulants. In three previously healthy, postmenopausal, Caucasian women with no antecedent thrombosis and previously undiagnosed G20210A prothrombin gene heterozygosity, hyperhomocysteinemia and 4G4G homozygosity of the PAI-1 gene, we describe central retinal vein thrombosis and osteonecrosis that developed at 16 days, 2 months and 11 months in the three cases, respectively, after T or TE therapy was started. Exogenous T or TE in postmenopausal women may be associated with thrombosis, speculatively when it is superimposed on underlying procoagulants. This small observational case series can serve as a starting point for a larger observational study with greater detail on patient history, serum T and estradiol levels, and detailed PCR and serologic assessment of thrombophilia and hypofibrinolysis. <\/jats:p>","DOI":"10.2217\/whe.13.31","type":"journal-article","created":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T10:26:28Z","timestamp":1373019988000},"page":"405-410","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Thrombosis in Three Postmenopausal Women Receiving Testosterone Therapy for Low Libido"],"prefix":"10.1177","volume":"9","author":[{"given":"Charles J","family":"Glueck","sequence":"first","affiliation":[{"name":"Jewish Hospital Cholesterol Center, Keystone Parke, 2135 Dana Avenue, Cincinnati, OH 45207, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dedrick","family":"Bowe","sequence":"additional","affiliation":[{"name":"Jewish Hospital Cholesterol Center, Keystone Parke, 2135 Dana Avenue, Cincinnati, OH 45207, USA"},{"name":"Internal Medical Residency Program, Jewish Hospital of Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Valdez","sequence":"additional","affiliation":[{"name":"Jewish Hospital Cholesterol Center, Keystone Parke, 2135 Dana Avenue, Cincinnati, OH 45207, USA"},{"name":"Internal Medical Residency Program, Jewish Hospital of Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Jewish Hospital Cholesterol Center, Keystone Parke, 2135 Dana Avenue, Cincinnati, OH 45207, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,7,1]]},"reference":[{"key":"bibr1-WHE.13.31","unstructured":"Papers of special note have been highlighted as:"},{"key":"bibr2-WHE.13.31","unstructured":"of considerable interest"},{"key":"bibr3-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2011.06.003"},{"key":"bibr4-WHE.13.31","unstructured":"Initial publication describing thrombotic events after starting exogenous testosterone in men with previously undiagnosed familial thrombophilia."},{"key":"bibr5-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0148-0"},{"key":"bibr6-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1080\/tam.5.2.98.102"},{"key":"bibr7-WHE.13.31","unstructured":"Important emphasis on aromatization of testosterone to estradiol."},{"key":"bibr8-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000149639.25136.CA"},{"key":"bibr9-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.639"},{"key":"bibr10-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00467.2005"},{"key":"bibr11-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.11.003"},{"key":"bibr12-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S34627"},{"key":"bibr13-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-008-0049-2"},{"key":"bibr14-WHE.13.31","doi-asserted-by":"crossref","unstructured":"Glueck CJ, Richardson-Royer C, Schultz R,  Testosterone, thrombophilia, and thrombosis. Clin. Appl. Thromb. Hemost. doi:10.1177\/1076029613485154 (2013) (Epub ahead of print).","DOI":"10.1177\/1076029613485154"},{"key":"bibr15-WHE.13.31","unstructured":"Second publication describing thrombotic events after starting exogenous testosterone in men with previously undiagnosed familial thrombophilia."},{"key":"bibr16-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80072-2"},{"key":"bibr17-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2011.01.005"},{"key":"bibr18-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.2217\/WHE.12.27"},{"key":"bibr19-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.14.1582"},{"key":"bibr20-WHE.13.31","unstructured":"Important randomized controlled clinical trial of the effects of testosterone supplementation on libido."},{"key":"bibr21-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000158103.27672.0d"},{"key":"bibr22-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1747"},{"key":"bibr23-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.2217\/17455057.2.3.459"},{"key":"bibr24-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000227400.60816.52"},{"key":"bibr25-WHE.13.31","doi-asserted-by":"crossref","unstructured":"Glueck CJ, Richardson-Royer C, Schultz R,  Testosterone, thrombophilia, thrombosis. Clin. Acquired Thromb. Hemost. doi:10.1177\/1076029613485154 (2013) (Epub ahead of print).","DOI":"10.1177\/1076029613485154"},{"key":"bibr26-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200412000-00009"},{"key":"bibr27-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614564"},{"key":"bibr28-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1177\/107602960501100404"},{"key":"bibr29-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2005.04.024"},{"key":"bibr30-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(93)90042-M"},{"key":"bibr31-WHE.13.31","doi-asserted-by":"crossref","unstructured":"Glueck CJ, Freiberg RA, Fontaine RN, Tracy T, Wang P. Hypofibrinolysis, thrombophilia, osteonecrosis. Clin. Orthop. Relat. Res. 19\u201333 (2001).","DOI":"10.1097\/00003086-200105000-00004"},{"key":"bibr32-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-004-0760-8"},{"key":"bibr33-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.00616"},{"key":"bibr34-WHE.13.31","doi-asserted-by":"crossref","unstructured":"Glueck CJ, Freiberg RA, Boriel G,  The role of the factor V leiden mutation in osteonecrosis of the hip. Clin. Appl. Thromb. Hemost. doi:10.1177\/1076029612449901 (2012) (Epub ahead of print).","DOI":"10.1177\/1076029612449901"},{"key":"bibr35-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540400055031"},{"key":"bibr36-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.150"},{"key":"bibr37-WHE.13.31","first-page":"76","volume":"151","author":"Kvasnicka J","year":"2012","journal-title":"Cas. Lek. Cesk"},{"key":"bibr38-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000485"},{"key":"bibr39-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2012.651925"},{"key":"bibr40-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2012.11.004"},{"key":"bibr41-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0888"},{"key":"bibr42-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.4.795"},{"key":"bibr43-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2007.03.016"},{"key":"bibr44-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-4-22"},{"key":"bibr45-WHE.13.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.05.057"}],"container-title":["Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2217\/WHE.13.31","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2217\/WHE.13.31","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2217\/WHE.13.31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T19:44:56Z","timestamp":1741635896000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2217\/WHE.13.31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.2217\/WHE.13.31"],"URL":"https:\/\/doi.org\/10.2217\/whe.13.31","relation":{},"ISSN":["1745-5057","1745-5065"],"issn-type":[{"value":"1745-5057","type":"print"},{"value":"1745-5065","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}