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Materials &amp; methods: In this open-label, uncontrolled, Phase IIb study, women (aged 18\u201335 years) used the patch for 13 cycles of 28 days. The primary variable was histologic endometrial effects at cycle 13. Secondary objectives included contraceptive efficacy and safety. Results: Overall, 89 women were treated. At all visits, endometrial biopsies were devoid of any abnormalities. One woman became pregnant. The patch was well tolerated, with no safety concerns. Conclusion: The ethinyl estradiol and gestodene patch had an endometrial effect consistent with suppression of endometrial proliferation in most patients. No endometrial abnormalities or other concerns were reported; compliance was good. <\/jats:p>","DOI":"10.2217\/whe.13.71","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T14:10:26Z","timestamp":1386771026000},"page":"37-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of an Ethinyl Estradiol\/Gestodene Transdermal Contraceptive Patch on the Endometrium: A Single-Center, Uncontrolled Study"],"prefix":"10.1177","volume":"10","author":[{"given":"Martin","family":"Merz","sequence":"first","affiliation":[{"name":"Bayer Pharma AG, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Grunert","sequence":"additional","affiliation":[{"name":"Bayer Pharma AG, 42096 Wuppertal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"bibr1a-WHE.13.71","unstructured":"Papers of special note have been highlighted as: \u2022 of interest"},{"key":"bibr1-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.13.1610"},{"key":"bibr2-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1080\/13625180400017776"},{"key":"bibr3-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1080\/13697130500148875"},{"key":"bibr4-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(90)90050-6"},{"key":"bibr5-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90550-Q"},{"key":"bibr6-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.04.027"},{"key":"bibr7-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1080\/13625180400008940"},{"key":"bibr9a-WHE.13.71","unstructured":"Reports data from a short study of a previous formulation of the ethinyl estradiol\/gestodene patch."},{"key":"bibr8-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2003.11.009"},{"key":"bibr9-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2005.06.057"},{"key":"bibr10-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1177\/106002809502907-817"},{"key":"bibr11-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199550020-00010"},{"key":"bibr14a-WHE.13.71","unstructured":"Provides a comprehensive review of gestodene as used in combined contraceptives."},{"key":"bibr12-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1080\/13625180400007736"},{"key":"bibr13-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)30692-2"},{"key":"bibr14-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1290.033"},{"key":"bibr15-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-005-9003-z"},{"key":"bibr16-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.suppl_1.101"},{"key":"bibr17-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70120-1"},{"key":"bibr18-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(99)00012-8"},{"key":"bibr19-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.3109\/13625189909085264"},{"key":"bibr23a-WHE.13.71","unstructured":"Reports data from a short study of a previous formulation of the ethinyl estradiol\/gestodene patch."},{"key":"bibr20-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.3109\/13625189709167476"},{"key":"bibr21-WHE.13.71","doi-asserted-by":"publisher","DOI":"10.3109\/13625189609150678"},{"key":"bibr101-WHE.13.71","unstructured":"Janssen\u2013Cilag Ltd. 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