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Comprehensive surgical staging followed by carboplatin and paclitaxel chemotherapy represents the mainstay of USC therapy. Vaginal cuff brachytherapy is also of potential benefit in USC. Recent whole-exome sequencing studies have demonstrated gain of function of the HER2\/NEU gene, as well as driver mutations in the PIK3CA\/AKT\/mTOR and cyclin E\/FBXW7 oncogenic pathways in a large number of USCs. 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