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Many women are reluctant to discuss painful sex and providers must proactively inquire about sexuality issues. Ospemifene has been shown to reverse changes associated with vulvovaginal atrophy and relieve symptoms of dyspareunia. Safety studies of treatment up to 52 weeks have shown ospemifene to be safe with no impact on endometrial hyperplasia\/carcinoma, venous thrombotic events or pelvic organ prolapse. Further studies are needed to evaluate its role in bone and breast health. <\/jats:p>","DOI":"10.2217\/whe.14.46","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T10:38:38Z","timestamp":1413974318000},"page":"499-503","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Ospemifene: A Novel Selective Estrogen Receptor Modulator for Treatment of Dyspareunia"],"prefix":"10.1177","volume":"10","author":[{"given":"Scott Evan","family":"Eder","sequence":"first","affiliation":[{"name":"Women's Health Research Center\/The Center for Women's Health & Wellness, LLC, 666 Plainsboro Road, Bld. 100, Suite D, Plainsboro, NJ 08536, USA, Tel.: +1 609 799 5010, Fax: +1 609 799 0819,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,9,1]]},"reference":[{"key":"bibr1a-WHE.14.46","unstructured":"Papers of special interest have been highlighted as:"},{"key":"bibr0101-WHE.14.46","unstructured":"of interest; \u2022\u2022 of considerable interest"},{"key":"bibr1-WHE.14.46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01335.x"},{"key":"bibr2-WHE.14.46","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31815a5168"},{"key":"bibr3-WHE.14.46","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12190"},{"key":"bibr4-WHE.14.46","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2010.522875"},{"key":"bibr5-WHE.14.46","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0046-y"},{"key":"bibr6-WHE.14.46","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31817b076a"},{"issue":"3","key":"bibr7-WHE.14.46","first-page":"888","volume":"20","author":"The North American Menopause Society","year":"2013","journal-title":"Menopause"},{"key":"bibr9a-WHE.14.46","unstructured":"Key overview of state of the art management of vulvovaginal atrophy."},{"key":"bibr8-WHE.14.46","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181a48c4e"},{"key":"bibr9-WHE.14.46","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000227401.98933.0b"},{"key":"bibr10-WHE.14.46","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0b013e31829755ed"},{"key":"bibr13a-WHE.14.46","unstructured":"Excellent review of selective estrogen receptor modulators and vaginal atrophy."},{"key":"bibr11-WHE.14.46","first-page":"605","volume":"5","author":"Soe LH","year":"2013","journal-title":"Int. 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