{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:27:56Z","timestamp":1741753676838,"version":"3.38.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p> Although it has been known for a long time that uterine fibroids respond to changes in sex steroid concentrations, it is the availability of selective progesterone receptor modulators such as ulipristal acetete that has provided the gynecologist with a novel option for medical management of uterine fibroids. Ulipristal acetate is presently licensed in Europe for use in women with symptomatic fibroids up to 3 months prior to surgery and has demonstrated good clinical efficacy and safety for this indication. Future trials will define the long-term safety of this drug and its role in medical management of uterine fibroids. <\/jats:p>","DOI":"10.2217\/whe.14.60","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T10:09:38Z","timestamp":1418033378000},"page":"565-570","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ulipristal Acetate for Use in Moderate to Severe Symptoms of Uterine Fibroids"],"prefix":"10.1177","volume":"10","author":[{"given":"Vikram Sinai","family":"Talaulikar","sequence":"first","affiliation":[{"name":"St George's Hospital & University of London, Cranmer Terrace, London, SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Manyonda","sequence":"additional","affiliation":[{"name":"St George's Hospital & University of London, Cranmer Terrace, London, SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,11,1]]},"reference":[{"key":"bibr1a-WHE.14.60","unstructured":"Papers of special note have been highlighted as:"},{"key":"bibr2a-WHE.14.60","unstructured":"of interest; \u2022\u2022 of considerable interest."},{"key":"bibr1-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32832e07e8"},{"key":"bibr4a-WHE.14.60","unstructured":"Provides mechanisms of action of ulipristal and its effects on body tissues."},{"key":"bibr2-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(00)00171-9"},{"volume-title":"Translational Research In Uterine Biology.","year":"2008","author":"Ohara N","key":"bibr3-WHE.14.60"},{"key":"bibr7a-WHE.14.60","unstructured":"Provides mechanisms of action of ulipristal and its effects on body tissues."},{"key":"bibr4-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gan004"},{"key":"bibr9a-WHE.14.60","unstructured":"Provides mechanisms of action of ulipristal and its effects on body tissues."},{"key":"bibr5-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1251483"},{"key":"bibr11a-WHE.14.60","unstructured":"Provides mechanisms of action of ulipristal and its effects on body tissues."},{"key":"bibr6-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181705d0e"},{"key":"bibr7-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.09.059"},{"key":"bibr14a-WHE.14.60","unstructured":"Forms the core clinical evidence for use of ulipristal."},{"key":"bibr8-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103182"},{"key":"bibr16a-WHE.14.60","unstructured":"Forms the core clinical evidence for use of ulipristal."},{"key":"bibr9-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103180"},{"key":"bibr18a-WHE.14.60","unstructured":"Forms the core clinical evidence for use of ulipristal."},{"key":"bibr10-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.02.008"},{"key":"bibr20a-WHE.14.60","unstructured":"Forms the core clinical evidence for use of ulipristal."},{"key":"bibr11-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-012-0206-0"},{"key":"bibr12-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm023"},{"key":"bibr13-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.19"},{"key":"bibr14-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.07.023"},{"key":"bibr15-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-012-0042-8"},{"key":"bibr16-WHE.14.60","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des221"},{"key":"bibr17-WHE.14.60","unstructured":"European Medicines Agency. Esmya \u2013 summary of product characteristics. www.ema.europa.eu"}],"container-title":["Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2217\/WHE.14.60","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2217\/WHE.14.60","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2217\/WHE.14.60","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T08:50:54Z","timestamp":1741683054000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2217\/WHE.14.60"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.2217\/WHE.14.60"],"URL":"https:\/\/doi.org\/10.2217\/whe.14.60","relation":{},"ISSN":["1745-5057","1745-5065"],"issn-type":[{"type":"print","value":"1745-5057"},{"type":"electronic","value":"1745-5065"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}