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Infertile women undergoing assisted reproduction are at a greater risk of having a miscarriage especially at an advanced age compared with women conceiving naturally. Aberrant expression of immunological factors and chromosomal abnormalities underlie both infertility and miscarriage. Common risk factors include increased maternal age, obesity, smoking, alcohol, pre-existing medical conditions and anatomical abnormalities of the reproductive system. Management pathways of both conditions may be similar with pre-implantation genetic testing and assisted reproductive technology used in both conditions. This paper discusses the synergies and differences between the two conditions in terms of their epidemiology, etiopathogenesis, risk factors and management strategies. The two conditions are related as degrees of severity of reproductive failure with common pathways in manifestation and management.<\/jats:p>","DOI":"10.2217\/whe.15.19","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T05:28:36Z","timestamp":1438666116000},"page":"527-541","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":69,"title":["Infertility and Miscarriage: Common Pathways in Manifestation and Management"],"prefix":"10.1177","volume":"11","author":[{"given":"Angena","family":"Agenor","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynaecology, University of Aberdeen Medical School, Foresterhill, Aberdeen, AB25 2ZD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohinee","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Dugald Baird Centre for Research on Women's Health, Aberdeen Maternity Hospital, Cornhill Road, Aberdeen, AB25 2ZL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"bibr1-WHE.15.19","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.2.113"},{"key":"bibr2-WHE.15.19","doi-asserted-by":"publisher","DOI":"10.1576\/toag.9.2.102.27311"},{"key":"bibr3-WHE.15.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2009.02.004"},{"key":"bibr4-WHE.15.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1995.tb00880.x"},{"issue":"5","key":"bibr5-WHE.15.19","first-page":"1510","volume":"172","author":"Hakim RB","year":"1995","journal-title":"Obstet. 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