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Lifestyle modification is considered the first-line treatment and is associated with improved endocrine profile. Clomiphene citrate (CC) should be considered as the first line pharmacologic therapy for ovulation induction. In women who are CC resistant, second-line treatment should be considered, as adding metformin, laparoscopic ovarian drilling or treatment with gonadotropins. In CC treatment failure, Letrozole could be an alternative or treatment with gonadotropins. IVF is considered the third-line treatment; the \u2018short\u2019, antagonist-based protocol is the preferred option for PCOS patients, as it is associated with lower risk of developing ovarian hyperstimulation syndrome (specifically by using a gonadotropin-releasing hormone agonist as ovulation trigger), but with comparable outcomes as the long protocol.<\/jats:p>","DOI":"10.2217\/whe.15.40","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T05:10:09Z","timestamp":1449033009000},"page":"901-912","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Treatment Strategies for the Infertile Polycystic Ovary Syndrome Patient"],"prefix":"10.1177","volume":"11","author":[{"given":"Samer","family":"Tannus","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynecology, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yechiel Z","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahar","family":"Kol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,11,1]]},"reference":[{"key":"bibr1a-whe.15.40","unstructured":"Papers of special note have been highlighted as:"},{"key":"bibr2a-whe.15.40","unstructured":"of interest; \u2022\u2022 of considerable interest."},{"key":"bibr1-whe.15.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61345-2"},{"key":"bibr2-whe.15.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"bibr3-whe.15.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.02.011"},{"key":"bibr4-whe.15.40","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.11165"},{"issue":"2","key":"bibr5-whe.15.40","first-page":"217","volume":"67","author":"Ravn P","year":"2015","journal-title":"Minerva Ginecol."},{"key":"bibr6-whe.15.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.11.070"},{"key":"bibr7-whe.15.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.05.006"},{"key":"bibr8-whe.15.40","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.462303.80"},{"issue":"3","key":"bibr9-whe.15.40","first-page":"129","volume":"32","author":"Mart\u00ednez-Bermejo E","year":"2007","journal-title":"Minerva Endocrinol."},{"issue":"2","key":"bibr10-whe.15.40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1515\/hmbci-2015-0008","volume":"21","author":"Sam S","year":"2015","journal-title":"Horm. 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