{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:39:41Z","timestamp":1792517981890,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p> Spontaneous preterm birth (sPTB) is the leading cause of neonatal morbidity and mortality globally. Accurate prediction of sPTB would enable targeting of interventions such as admission to hospital, antenatal corticosteroids, magnesium sulphate and in utero transfer as well as guiding prophylactic treatment (e.g., cerclage or progesterone). Measurement of fetal fibronectin concentration in the cervicovaginal fluid is a known predictor of sPTB. Traditionally a positive\/negative test (defined by a threshold of 50 ng\/ml), recent work has demonstrated improved prediction when used as a quantitative test, whereby the concentration of fetal fibronectin is measured by an automated bedside reader. This review examines the evidence surrounding the use of quantitative fetal fibronectin in asymptomatic women at high risk of sPTB, as well as those with symptoms of threatened sPTB. <\/jats:p>","DOI":"10.2217\/whe.15.74","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T16:29:48Z","timestamp":1449851388000},"page":"121-128","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Quantitative Fetal Fibronectin to Predict Spontaneous Preterm Birth: A Review"],"prefix":"10.1177","volume":"12","author":[{"given":"Natasha L","family":"Hezelgrave","sequence":"first","affiliation":[{"name":"Division of Women's Health, Kings College London, Women's Health Academic Centre, Kings Health Partners, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H","family":"Shennan","sequence":"additional","affiliation":[{"name":"Division of Women's Health, Kings College London, Women's Health Academic Centre, Kings Health Partners, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"bibr1a-whe.15.74","unstructured":"Papers of special note have been highlighted as: \u2022 of interest; \u2022\u2022 of considerable interest"},{"key":"bibr1-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"key":"bibr1b-whe.15.74","unstructured":"An excellent review of the most recent epidemiology of preterm birth in a global context."},{"key":"bibr2-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"bibr3-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"bibr4-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000168435.17200.53"},{"key":"bibr5-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.12.003"},{"key":"bibr6-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60030-0"},{"key":"bibr7-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.06.055"},{"key":"bibr8-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109053251001"},{"key":"bibr9-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00035-X"},{"key":"bibr10-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7359.301"},{"key":"bibr11-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70431-9"},{"key":"bibr12-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00420.x"},{"issue":"4","key":"bibr13-whe.15.74","first-page":"CD006843","author":"Berghella V","year":"2008","journal-title":"Cochrane Database Syst. Rev."},{"key":"bibr13a-whe.15.74","unstructured":"Cochrane review synthesising the effect of fetal fibronectin (fFN) testing on rates of spontaneous preterm birth."},{"key":"bibr14-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.01.018"},{"key":"bibr15-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000754"},{"key":"bibr15a-whe.15.74","unstructured":"First prospective study to evaluate predictive potential of fFN using a bedside reader, for prediction of preterm birth in asymptomatic women at high risk of preterm birth between 22 and 27 weeks of gestation."},{"key":"bibr16-whe.15.74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.10.890"},{"key":"bibr16a-whe.15.74","unstructured":"First prospective study to evaluate predictive potential of fFN using a bedside reader, for prediction of preterm birth in women symptomatic of preterm labor as between 22 and 35 weeks of gestation."},{"key":"bibr17-whe.15.74","doi-asserted-by":"crossref","unstructured":"Kuhrt K, Hezelgrave N, Foster C, Seed PT, Shennan AH. Development and validation of a predictive tool for spontaneous preterm birth, incorporating quantitative fetal fibronectin, in symptomatic women. Ultrasound Obstetr. Gynecol. doi:10.1002\/uog.14894 (2015) (Epub ahead of print).","DOI":"10.1002\/uog.14894"},{"key":"bibr17a-whe.15.74","unstructured":"Validation of predictive algorithm incorporating quantitative fFN, prior history and gestational age to predict individual risk of preterm birth in symptomatic women."},{"key":"bibr18-whe.15.74","doi-asserted-by":"crossref","unstructured":"Kuhrt K, Smout E, Hezelgrave N, Seed PT, Carter J, Shennan AH. Development and validation of a predictive tool for spontaneous preterm birth incorporating cervical length and quantitative fetal fibronectin in asymptomatic high-risk women. Ultrasound Obstetr. 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