{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:33:18Z","timestamp":1791307998399,"version":"4.3.1"},"reference-count":66,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p> Preeclampsia (PE) is a multisystem disorder of pregnancy classically characterized with the onset of hypertension after 20 weeks gestation in the presence of proteinuria. PE typically affects 2\u20138% of pregnancies and is a leading cause of maternal and perinatal morbidity and mortality. This article reviews the most effective biomarkers used in first trimester screening for PE. It explores their use both in isolation and as part of an algorithm to yield the best detection rates. Screening by a combination of maternal risk factors, uterine artery Doppler, mean arterial pressure, maternal serum PAPP-A and PlGF can identify about 75% of cases of preterm PE for a false-positive rate of 10%. By identifying these patients at high risk for PE, appropriately tailored antenatal surveillance can be instigated and prophylactic pharmacological interventions can be prescribed to improve placentation and ultimately, the outcome for both the mother and fetus. <\/jats:p>","DOI":"10.2217\/whe.15.95","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T17:22:49Z","timestamp":1456161769000},"page":"199-207","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["The Use of Ultrasound and other Markers for Early Detection of Preeclampsia"],"prefix":"10.1177","volume":"12","author":[{"given":"Neil","family":"O'Gorman","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kypros H","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liona CY","family":"Poon","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"key":"bibr1a-whe.15.95","unstructured":"Papers of special note have been highlighted as: \u2022 of interest; \u2022\u2022 of considerable interest"},{"key":"bibr1-whe.15.95","volume-title":"Make Every Mother and Child Count. World Health Report, 2005","author":"WHO","year":"2005"},{"key":"bibr2-whe.15.95","volume-title":"England, Wales and Northern Ireland","author":"Confidential Enquiry into Maternal and Child Health (CEMACH) Perinatal Mortality 2006","year":"2008"},{"key":"bibr3-whe.15.95","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"bibr3a-whe.15.95","unstructured":"This article provides an excellent background of preeclampsia (PE). It describes the seriousness of the disorder and its impact on a global scale."},{"key":"bibr4-whe.15.95","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5252"},{"key":"bibr5-whe.15.95","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.104224"},{"key":"bibr6-whe.15.95","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7323.1213"},{"key":"bibr7-whe.15.95","doi-asserted-by":"publisher","DOI":"10.1081\/PRG-120021060"},{"key":"bibr8-whe.15.95","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e9322a"},{"key":"bibr8a-whe.15.95","unstructured":"This meta-analysis shows that low-dose aspirin started before 16 weeks significantly reduces the incidence of preterm PE, gestational hypertension, preterm birth and IUGR."},{"key":"bibr9-whe.15.95","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.034"},{"key":"bibr9a-whe.15.95","unstructured":"A prospective analysis of a 1st trimester screening model for PE. This study has large numbers with excellent detection rates, especially for PE <34 weeks."},{"key":"bibr10-whe.15.95","doi-asserted-by":"publisher","DOI":"10.1159\/000341264"},{"key":"bibr11-whe.15.95","volume-title":"Hypertensionin Pregnancy: The Management of Hypertensive Disorders During Pregnancy.","author":"National Collaborating Centre for Women's and Children's Health (UK)","year":"2010"},{"key":"bibr12-whe.15.95","unstructured":"WHO, Department. of Reproductive Health and Research, Department. of Maternal, Newborn, Child and Adolescent Health, Department. of Nutrition for Health and Development. WHO recommendations for prevention and treatment of pre-eclampsia and eclampsia (2011). www.preeclampsia.org"},{"key":"bibr13-whe.15.95","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32776-1"},{"key":"bibr14-whe.15.95","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/01.AOG.0000437382.03963.88","volume":"122","author":"American College of Obstetricians and Gynecologists","year":"2013","journal-title":"Obstet. 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