{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:55:17Z","timestamp":1791456917298,"version":"4.3.4"},"reference-count":79,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T00:00:00Z","timestamp":1458000000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Hereditary angioedema (HAE) is a rare disorder resulting from decreased functional levels of C1 -inhibitor (C1-INH), which manifests as periodic episodes of localized edema which can be extremely painful, debilitating and even fatal if the swelling affects the larynx. HAE can complicate many aspects of obstetric\/gynecologic care, and an awareness of the disease is critical for clinicians involved in the care of women because of potential HAE-related complications pertaining to pregnancy, labor and delivery, and other women's health issues. This article provides a review of published literature specific to HAE and its management in female patients, including important concerns regarding obstetric\/gynecologic care. A growing body of relevant experience is presented to help guide the care of women with HAE.<\/jats:p>","DOI":"10.2217\/whe.16.6","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T10:21:12Z","timestamp":1458037272000},"page":"351-361","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Managing the Female Patient with Hereditary Angioedema"],"prefix":"10.1177","volume":"12","author":[{"given":"Aleena","family":"Banerji","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital, Cox 201, 55 Fruit Street, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Riedl","sequence":"additional","affiliation":[{"name":"University of California, San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"bibr1a-whe.16.6","unstructured":"Papers of special note have been highlighted as: \u2022 of interest; \u2022 \u2022 of considerable interest"},{"key":"bibr1-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0803977"},{"key":"bibr2-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.064"},{"key":"bibr3-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.01.007"},{"key":"bibr4-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111326"},{"key":"bibr5-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02483-1"},{"key":"bibr6-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.108106"},{"key":"bibr7-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.06.004"},{"key":"bibr8-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.02.020"},{"key":"bibr9-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2012.05.022"},{"key":"bibr10-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1086\/509899"},{"key":"bibr11-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2011.07.002"},{"key":"bibr12-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.03.038"},{"key":"bibr13-whe.16.6","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3627"},{"key":"bibr1b-whe.16.6","unstructured":"\u2022 Recent consensus document on hereditary angioedema (HAE) with normal C1 inhibitor, a type of HAE with higher prevalence in females and often difficult to diagnose"},{"key":"bibr14-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2014.05.010"},{"key":"bibr15-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb05858.x"},{"key":"bibr16-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.04.034"},{"key":"bibr1c-whe.16.6","unstructured":"\u2022 Large questionnaire-based, international study of the course of HAE in women"},{"key":"bibr17-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40822-5"},{"key":"bibr18-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09716.x"},{"key":"bibr19-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb12956.x"},{"key":"bibr20-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.5.1404"},{"key":"bibr21-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1097\/00042192-200105000-00011"},{"key":"bibr22-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(92)90069-C"},{"key":"bibr23-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1210\/endo.136.11.7588244"},{"key":"bibr24-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V66.3.602.602"},{"key":"bibr25-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(96)00037-2"},{"key":"bibr26-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701255"},{"key":"bibr27-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.06.047"},{"key":"bibr28-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2009.12.004"},{"key":"bibr29-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1097\/NAN.0000000000000049"},{"key":"bibr30-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00492.x"},{"key":"bibr31-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2003.08.007"},{"key":"bibr32-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.12.791"},{"key":"bibr33-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.08.021"},{"key":"bibr34-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.20.2417"},{"key":"bibr35-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.03.034"},{"key":"bibr36-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.07.002"},{"key":"bibr37-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12584"},{"key":"bibr38-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.11.025"},{"key":"bibr1d-whe.16.6","unstructured":"\u2022\u2022 The most recent consensus document on the management of female patients with HAE (6th C1 Inhibitor Deficiency Workshop, Budapest, Hungary, 2009)"},{"key":"bibr39-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02751.x"},{"key":"bibr40-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.08.017"},{"key":"bibr41-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e318279affa"},{"key":"bibr42-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.03.003"},{"key":"bibr1e-whe.16.6","unstructured":"\u2022 Observational study of disease patterns 22 women (35 pregnancies) with HAE"},{"key":"bibr43-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.05.008"},{"key":"bibr1f-whe.16.6","unstructured":"\u2022 Retrospective study analyzing attack patterns and outcomes among 188 pregnancies in 41 women with HAE"},{"key":"bibr44-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2008.00945.x"},{"key":"bibr45-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.03.004"},{"issue":"2","key":"bibr46-whe.16.6","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0022-3565(25)38423-5","volume":"266","author":"Schriefer JA","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"bibr47-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1996.418764000.x"},{"key":"bibr48-whe.16.6","first-page":"54","volume":"69","author":"McGlinchey PG","year":"2000","journal-title":"Ulster Med. J."},{"key":"bibr49-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701411851"},{"key":"bibr50-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-007-0329-1"},{"key":"bibr51-whe.16.6","first-page":"365","volume":"54","author":"Gorman PJ","year":"2008","journal-title":"Can. Fam. Physician"},{"key":"bibr52-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.05.008"},{"key":"bibr53-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2012.09.009"},{"key":"bibr54-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.07.010"},{"key":"bibr55-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-6-24"},{"key":"bibr56-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2012.10.008"},{"key":"bibr57-whe.16.6","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2013.34.3645"},{"key":"bibr58-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02726.x"},{"key":"bibr59-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649475"},{"key":"bibr60-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-006-0183-6"},{"key":"bibr61-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1080\/01443619964427"},{"key":"bibr62-whe.16.6","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2013.34.3635"},{"key":"bibr63-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1157\/13106781"},{"key":"bibr64-whe.16.6","first-page":"287","volume":"58","author":"Raychaudhuri K","year":"1997","journal-title":"Brit. J. Hosp. Med."},{"key":"bibr65-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.05.016"},{"key":"bibr66-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0771-z"},{"key":"bibr67-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01526-7"},{"key":"bibr68-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1159\/000068456"},{"key":"bibr69-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12055"},{"key":"bibr70-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3117"},{"key":"bibr71-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.01038"},{"key":"bibr72-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70301-2"},{"key":"bibr73-whe.16.6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp295"}],"container-title":["Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2217\/whe.16.6","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2217\/whe.16.6","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2217\/whe.16.6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T16:01:56Z","timestamp":1748793716000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2217\/whe.16.6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,15]]},"references-count":79,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.2217\/whe.16.6"],"URL":"https:\/\/doi.org\/10.2217\/whe.16.6","relation":{},"ISSN":["1745-5057","1745-5065"],"issn-type":[{"value":"1745-5057","type":"print"},{"value":"1745-5065","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,15]]}}}