{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:35:20Z","timestamp":1747208120236,"version":"3.40.5"},"reference-count":28,"publisher":"Informa UK Limited","issue":"19","funder":[{"name":"Programa Operacional Regional do Norte","award":["NORTE-01-0145-FEDER-072678"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-072678"]}]},{"name":"Research Center of Portuguese Oncology Institute of Porto","award":["CI-IPOP-27-2016","PI 160-CI-IPOP-2021"],"award-info":[{"award-number":["CI-IPOP-27-2016","PI 160-CI-IPOP-2021"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Epigenomics"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.2217\/epi-2021-0333","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T10:39:00Z","timestamp":1633603140000},"page":"1514-1521","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Epigenetic extracellular vesicle-based biomarkers for urological malignancies: is the hope worth the hype?"],"prefix":"10.1080","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-4589","authenticated-orcid":false,"given":"Diana","family":"Montezuma","sequence":"first","affiliation":[{"name":"Cancer Biology & Epigenetics Group, Research Center of IPO Porto (CI-IPOP) \/ RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), R. Dr. António Bernardino de Almeida, Porto, 4200-072, Portugal."},{"name":"Doctoral Programme in Medical Sciences, School of Medicine & Biomedical Sciences, University of Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira 228, Porto, 4050-513, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1396-3466","authenticated-orcid":false,"given":"Ana","family":"Teixeira-Marques","sequence":"additional","affiliation":[{"name":"Cancer Biology & Epigenetics Group, Research Center of IPO Porto (CI-IPOP) \/ RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), R. Dr. António Bernardino de Almeida, Porto, 4200-072, Portugal."},{"name":"Master in Medicine & Molecular Oncology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto, 4200-319, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-5345","authenticated-orcid":false,"given":"Carmen","family":"Jerónimo","sequence":"additional","affiliation":[{"name":"Cancer Biology & Epigenetics Group, Research Center of IPO Porto (CI-IPOP) \/ RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), R. Dr. António Bernardino de Almeida, Porto, 4200-072, Portugal."},{"name":"Department of Pathology & Molecular Immunology, ICBAS, School of Medicine & Biomedical Sciences, University of Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira 228, Porto, 4050-513, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3171-4666","authenticated-orcid":false,"given":"Rui","family":"Henrique","sequence":"additional","affiliation":[{"name":"Cancer Biology & Epigenetics Group, Research Center of IPO Porto (CI-IPOP) \/ RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), R. Dr. António Bernardino de Almeida, Porto, 4200-072, Portugal."},{"name":"Department of Pathology & Molecular Immunology, ICBAS, School of Medicine & Biomedical Sciences, University of Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira 228, Porto, 4050-513, Portugal"},{"name":"Department of Pathology, Portuguese Oncology Institute of Porto (IPOP), R. Dr. António Bernardino de Almeida, Porto, 4200-072, Portugal"}]}],"member":"301","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/649161"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-01891-0"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI146431"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6899"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2016.2359"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.08.019"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.01.074"},{"key":"e_1_3_2_12_1","unstructured":"ClinicalTrials.gov\n. Clinical evaluation of the miR Sentinel BCa™ test to diagnose bladder cancer in hematuria patients (2019). www.clinicaltrials.gov\/ct2\/show\/NCT04155359?term=exosomes&cond=bladder&draw=2&rank=1"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188570"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147236"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau-20-1039"},{"issue":"11","key":"e_1_3_2_16_1","first-page":"2500","article-title":"A non-invasive miRNA based assay to detect bladder cancer in cell-free urine","volume":"7","author":"Long JD","year":"2015","unstructured":"Long JD , SullivanTB , HumphreyJet al. A non-invasive miRNA based assay to detect bladder cancer in cell-free urine. Am. J. Transl. Res.7(11), 2500–2509 (2015).","journal-title":"Am. J. Transl. Res."},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.11.018"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13071529"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12093"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau-20-1210"},{"key":"e_1_3_2_21_1","first-page":"168","article-title":"Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease","volume":"6","author":"Işın M","year":"2015","unstructured":"Işın M , UysalerE , ÖzgürEet al. Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease. Front. Genet. 6, 168 (2015).","journal-title":"Front. Genet"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605512"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2020_191130N1234"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0036-9"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00258-9"},{"issue":"1","key":"e_1_3_2_26_1","first-page":"4","article-title":"Urinary exosomal and cell-free DNA detects somatic mutation and copy number alteration in urothelial carcinoma of bladder","volume":"8","author":"Lee DH","year":"2018","unstructured":"Lee DH , YoonH , ParkSet al. Urinary exosomal and cell-free DNA detects somatic mutation and copy number alteration in urothelial carcinoma of bladder. Sci. Rep.8(1), 4–10 (2018).","journal-title":"Sci. Rep."},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-3313"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7LC00592J"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79139-8"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2019.1665508"}],"container-title":["Epigenomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/epi-2021-0333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T23:43:43Z","timestamp":1715989423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/epi-2021-0333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":28,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.2217\/epi-2021-0333"],"URL":"https:\/\/doi.org\/10.2217\/epi-2021-0333","relation":{},"ISSN":["1750-1911","1750-192X"],"issn-type":[{"type":"print","value":"1750-1911"},{"type":"electronic","value":"1750-192X"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iepi20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}