{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T22:36:46Z","timestamp":1774391806116,"version":"3.50.1"},"reference-count":52,"publisher":"Informa UK Limited","issue":"12","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine (Lond.)"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.2217\/nnm-2017-0023","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T13:26:34Z","timestamp":1495200394000},"page":"1385-1399","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":48,"title":["Delivery of siRNA Silencing P-gp in Peptide-Functionalized Nanoparticles Causes Efflux Modulation at the Blood\u2013Brain Barrier"],"prefix":"10.1080","volume":"12","author":[{"given":"Maria Jo\u00e3o","family":"Gomes","sequence":"first","affiliation":[{"name":"i3S, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Rua Alfredo Allen, 208, 4200\u2013135, Porto, Portugal"},{"name":"INEB, Instituto de Engenharia Biom\u00e9dica, Biocarrier Group, Rua Alfredo Allen, 208, 4200\u2013135, Porto, Portugal"},{"name":"ICBAS, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050\u2013313, Porto, Portugal"}]},{"given":"Patrick J","family":"Kennedy","sequence":"additional","affiliation":[{"name":"i3S, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Rua Alfredo Allen, 208, 4200\u2013135, Porto, Portugal"},{"name":"INEB, Instituto de Engenharia Biom\u00e9dica, Biocarrier Group, Rua Alfredo Allen, 208, 4200\u2013135, Porto, Portugal"},{"name":"ICBAS, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050\u2013313, Porto, Portugal"},{"name":"IPATIMUP, Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Alfredo Allen, 208, 4200\u2013393, Porto, Portugal"}]},{"given":"Susana","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry &amp; Pharmacy, University of Southern Denmark, Campusvej 55, Odense, DK-5230, Denmark"}]},{"given":"Bruno","family":"Sarmento","sequence":"additional","affiliation":[{"name":"i3S, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Rua Alfredo Allen, 208, 4200\u2013135, Porto, Portugal"},{"name":"INEB, Instituto de Engenharia Biom\u00e9dica, Biocarrier Group, Rua Alfredo Allen, 208, 4200\u2013135, Porto, Portugal"},{"name":"CESPU, Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade, Rua Central de Gandra, 1317, 4585\u2013116, Gandra, Portugal"}]}],"member":"301","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.03.001"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12497"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.07.030"},{"issue":"3","key":"e_1_3_3_6_1","first-page":"1","article-title":"Multifunctional nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging","volume":"7","author":"Bhaskar S","year":"2010","unstructured":"Bhaskar S Tian F Stoeger T et al. Multifunctional nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging. Part. Fibre Toxicol.7 (3), 1 \u2013 25 (2010).","journal-title":"Part. Fibre Toxicol."},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211797440221"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl1126"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.10.045"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-016-9685-6"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054182"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.07.028"},{"issue":"16","key":"e_1_3_3_13_1","first-page":"1","article-title":"The hCMEC\/D3 cell line as a model of the human blood brain barrier","volume":"10","author":"Weksler B","year":"2013","unstructured":"Weksler B Romero IA Couraud PO . The hCMEC\/D3 cell line as a model of the human blood brain barrier. Fluids Barriers CNS10 (16), 1 \u2013 10 (2013).","journal-title":"Fluids Barriers CNS"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.08.076"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm5010383"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b02762"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.01.008"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.49"},{"issue":"28","key":"e_1_3_3_19_1","first-page":"1","article-title":"Improved anticancer delivery of paclitaxel by albumin surface modification of PLGA nanoparticles","volume":"23","author":"Esfandyari-Manesh M","year":"2015","unstructured":"Esfandyari-Manesh M Mostafavi SH Majidi RF et al. Improved anticancer delivery of paclitaxel by albumin surface modification of PLGA nanoparticles. Daru23 (28), 1 \u2013 8 (2015).","journal-title":"Daru"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.05.027"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007049"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098023"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.04.050"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.02.013"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2009.12.018"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-110323"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp300668e"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.10.031"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.08.039"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/la052797j"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05730.x"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2010.12.024"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.06.029"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.10.068"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200407113"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156754"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.096"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.10.011"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.08.032"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041630314"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/oli.2004.14.191"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2014.12.006"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04410.x"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.12.023"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2005.10.014"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA25333K"},{"issue":"1653","key":"e_1_3_3_47_1","first-page":"1","article-title":"Transfection efficiency influenced by aggregation of DNA\/polyethylenimine max\/magnetic nanoparticle complexes","volume":"15","author":"Ota S","year":"2013","unstructured":"Ota S Takahashi Y Tomitaka A et al. Transfection efficiency influenced by aggregation of DNA\/polyethylenimine max\/magnetic nanoparticle complexes. J. Nanopart. Res.15 (1653), 1 \u2013 12 (2013).","journal-title":"J. Nanopart. Res."},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2013.8"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.09.048"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1124-2"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.833.3.7"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.11.93"},{"issue":"3","key":"e_1_3_3_53_1","first-page":"177","article-title":"Inhibition of P-glycoprotein expression and function by antidiabetic drugs gliclazide, metformin, and pioglitazone in vitro and in situ","volume":"11","author":"Abbasi MM","year":"2016","unstructured":"Abbasi MM Valizadeh H Hamishehkar H Zakerimilani P . Inhibition of P-glycoprotein expression and function by antidiabetic drugs gliclazide, metformin, and pioglitazone in vitro and in situ. Res. Pharm. Sci.11 (3), 177 \u2013 186 (2016).","journal-title":"Res. Pharm. Sci."},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.06.144"}],"container-title":["Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.2217\/nnm-2017-0023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:50:21Z","timestamp":1716493821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.2217\/nnm-2017-0023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,19]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.2217\/nnm-2017-0023"],"URL":"https:\/\/doi.org\/10.2217\/nnm-2017-0023","relation":{},"ISSN":["1743-5889","1748-6963"],"issn-type":[{"value":"1743-5889","type":"print"},{"value":"1748-6963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,19]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=innm20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2017-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}