{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:34:52Z","timestamp":1779262492573,"version":"3.51.4"},"reference-count":22,"publisher":"Biomedical Research Press","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomed. Res."],"published-print":{"date-parts":[[2014]]},"DOI":"10.2220\/biomedres.35.389","type":"journal-article","created":{"date-parts":[[2014,12,21]],"date-time":"2014-12-21T10:35:34Z","timestamp":1419158134000},"page":"389-395","source":"Crossref","is-referenced-by-count":21,"title":["Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose"],"prefix":"10.2220","volume":"35","author":[{"given":"Tomoya","family":"ARAI","sequence":"first","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"KOYAMA","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"YUASA","sequence":"additional","affiliation":[{"name":"Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"KITAMURA","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryushin","family":"MIZUTA","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1059","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Aruoma OI, Halliwell B, Hoey BM and Butler J (1989) The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. <i>Free Radic Biol Med <\/i><b>6<\/b>, 593\u2013597.","DOI":"10.1016\/0891-5849(89)90066-X"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 rous acid. <i>Free Radic Biol Med<\/i><b>6<\/b>, 593\u2013597. Calingasan NY, Uchida K and Gibson GE (1999) Proteinbound acrolein: a novel marker of oxidative stress in Al zheimer\u2019s disease. <i>J Neurochem <\/i><b>72<\/b>, 751\u2013756.","DOI":"10.1046\/j.1471-4159.1999.0720751.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Daimon M, Sugiyama K, Kameda W, Saitoh T, Oizumi T, Hirata A, Yamaguchi H, Ohnuma H, Igarashi M and Kato T (2003) Increased urinary levels of pentosidine, pyrraline and acrolein adduct in type 2 diabetes. <i>Endocr J <\/i><b>50<\/b>, 61\u201367.","DOI":"10.1507\/endocrj.50.61"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Hamann K, Durkes A, Ouyang H, Uchida K, Pond A and Shi R (2008) Critical role of acrolein in secondary injury following ex vivo spinal cord trauma. <i>J Neurochem <\/i><b>107<\/b>, 712\u2013721.","DOI":"10.1111\/j.1471-4159.2008.05622.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Ishida Y, Kondo T, Kimura A, Tsuneyama K, Takayasu T and Mukaida N (2006) Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury. <i>Eur J Immunol <\/i><b>36<\/b>, 1028\u20131038.","DOI":"10.1002\/eji.200535261"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Kaplowitz N (2004) Acetaminophen hepatoxicity: what do we know, what don\u2019t we know, and what do we do next? <i>Hepatology <\/i><b>40<\/b>, 23\u201326.","DOI":"10.1002\/hep.20312"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 <i>Hepatology<\/i><b>40<\/b>, 23\u201326. Kehrer JP and Biswal SS (2000) The molecular effects of acrolein. <i>Toxicol Sci <\/i><b>57<\/b>, 6\u201315.","DOI":"10.1093\/toxsci\/57.1.6"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Lovell MA, Xie C and Markesbery WR (2001) Acrolein is increased in Alzheimer\u2019s disease brain and is toxic to primary hippocampal cultures. <i>Neurobiol Aging <\/i><b>22<\/b>, 187\u2013194.","DOI":"10.1016\/S0197-4580(00)00235-9"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Mizuta R, Araki S, Furukawa M, Furukawa Y, Ebara S, Shiokawa D, Hayashi K, Tanuma S and Kitamura D (2013) DNase \u03b3 is the effector endonuclease for internucleosomal DNA fragmentation in necrosis. <i>PLoS One <\/i><b>8<\/b>, e80223.","DOI":"10.1371\/journal.pone.0080223"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Mohammad MK, Avila D, Zhang J, Barve S, Arteel G, McClain C and Joshi-Barve S (2012) Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress. <i>Toxicol Appl Pharmacol <\/i><b>265<\/b>, 73\u201382.","DOI":"10.1016\/j.taap.2012.09.021"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Perry HE and Shannon MW (1998) Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: re sults of an open-label, clinical trial. <i>J Pediatr <\/i><b>132<\/b>, 149\u2013152.","DOI":"10.1016\/S0022-3476(98)70501-3"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Saiki R, Park H, Ishii I, Yoshida M, Nishimura K, Toida T, Tatsukawa H, Kojima S, Ikeguchi Y, Pegg AE, <i>et al.<\/i> (2011) Brain infarction correlates more closely with acrolein than with reactive oxygen species. <i>Biochem Biophys Res Commun <\/i><b>404<\/b>, 1044\u20131049.","DOI":"10.1016\/j.bbrc.2010.12.107"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 <b>404<\/b>, 1044\u20131049. Sakata K, Kashiwagi K, Sharmin S, Ueda S, Irie Y, Murotani N and Igarashi K (2003) Increase in putrescine, amine oxidase, and acrolein in plasma of renal failure patients. <i>Biochem Biophys Res Commun <\/i><b>305<\/b>, 143\u2013149.","DOI":"10.1016\/S0006-291X(03)00716-2"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Sener G, Sehirli O, Cetinel S, Ye\u011fen BG, Gedik N and Ayano\u011flu-D\u00fclger G (2005) Protective effects of MESNA (2-mercaptoethane sulphonate) against acetaminophen-induced hepatorenal oxidative damage in mice. <i>J Appl Toxicol <\/i><b>25<\/b>, 20\u201329.","DOI":"10.1002\/jat.1012"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Shamoto-Nagai M, Maruyama W, Hashizume Y, Yoshida M, Osawa T, Riederer P and Naoi M (2007) In parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity. <i>J Neural Transm <\/i><b>114<\/b>, 1559\u20131567.","DOI":"10.1007\/s00702-007-0789-2"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Sharmin S, Sakata K, Kashiwagi K, Ueda S, Iwasaki S, Shirahata A and Igarashi K (2001) Polyamine cytotoxicity in the presence of bovine serum amine oxidase. <i>Biochem Biophys Res Commun <\/i><b>282<\/b>, 228\u2013235.","DOI":"10.1006\/bbrc.2001.4569"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Takahashi T, Morita K, Akagi R and Sassa S (2004) Heme oxygenase-1: a novel therapeutic target in oxidative tissue in juries. <i>Curr Med Chem <\/i><b>11<\/b>, 1545\u20131561.","DOI":"10.2174\/0929867043365080"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 juries. <i>Curr Med Chem<\/i><b>11<\/b>, 1545\u20131561. Takamoto S, Sakura N, Yashiki M and Kojima T (2003) Inactivation of acrolein by sodium 2-mercaptoethanesulfonate using headspace-solid-phase microextraction gas chromatography and mass spectrometry. <i>J Chromatogr B Analyt Technol Biomed Life Sci <\/i><b>791<\/b>, 365\u2013369.","DOI":"10.1016\/S1570-0232(03)00259-9"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Uchida K, Kanematsu M, Morimitsu Y, Osawa T, Noguchi N and Niki E (1998) Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins. <i>J Biol Chem <\/i><b>273<\/b>, 16058\u201316066.","DOI":"10.1074\/jbc.273.26.16058"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Uchida K, Kanematsu M, Sakai K, Matsuda T, Hattori N, Mizuno Y, Suzuki D, Miyata T, Noguchi N, Niki E, <i>et al.<\/i> (1998) Protein-bound acrolein: potential markers for oxidative stress. <i>Proc Natl Acad Sci USA <\/i><b>95<\/b>, 4882\u20134887.","DOI":"10.1073\/pnas.95.9.4882"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Weinhold B (2011) Acrolein and neuro disorders. <i>Environ Health Perspect <\/i><b>119<\/b>, A68.","DOI":"10.1289\/ehp.119-a68a"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Yoshida M, Tomitori H, Machi Y, Hagihara M, Higashi K, Goda H, Ohya T, Niitsu M, Kashiwagi K and Igarashi K (2009) Acrolein toxicity: Comparison with reactive oxygen species. <i>Biochem Biophys Res Commun <\/i><b>378<\/b>, 313\u2013318.","DOI":"10.1016\/j.bbrc.2008.11.054"}],"container-title":["Biomedical Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T17:30:29Z","timestamp":1566149429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/biomedres\/35\/6\/35_389\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2220\/biomedres.35.389","relation":{},"ISSN":["0388-6107","1880-313X"],"issn-type":[{"value":"0388-6107","type":"print"},{"value":"1880-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}