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cells in the rat gut identified by expression of alpha-gustducin. <i>Proc Natl Acad Sci USA <\/i><b>93<\/b>, 6631\u20136634.","DOI":"10.1073\/pnas.93.13.6631"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, <i>et al.<\/i> (2016) Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. <i>Science <\/i><b>351<\/b>, 1329\u20131333.","DOI":"10.1126\/science.aaf1648"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Jarvi O and Keyrilainen O (1956) On the cellular structures of the epithelial invasions in the glandular stomach of mice caused by intramural application of 20-methylcholantren. <i>Acta Pathol Microbiol Scand Suppl <\/i><b>39<\/b>, 72\u201373.","DOI":"10.1111\/j.1600-0463.1956.tb06739.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Kaji I, Roland JT, Engevik AC, Goldstein AE and Goldenring JR (2019) Lysophosphatidic acid treatment ameliorates the function of apical 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