{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T04:53:15Z","timestamp":1743828795861},"reference-count":19,"publisher":"Biomedical Research Press","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomed. Res."],"published-print":{"date-parts":[[2020,10,16]]},"DOI":"10.2220\/biomedres.41.253","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T22:08:59Z","timestamp":1602799739000},"page":"253-257","source":"Crossref","is-referenced-by-count":2,"title":["Effects of nafamostat mesilate on 5-hydroxytryptamine release from isolated ileal tissues induced by anti-cancer drugs in rats"],"prefix":"10.2220","volume":"41","author":[{"given":"Kaoru","family":"KIKUCHI","sequence":"first","affiliation":[{"name":"Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"HAMAUE","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuji","family":"MACHIDA","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"IIZUKA","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"MINAMI","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"HIRAFUJI","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1059","reference":[{"key":"1","unstructured":"Aoyama T, Ino Y, Ozeki M, Oda M, Sato T, <i>et al.<\/i> (1984) Pharmacological studies of FUT-175, nafamostat mesilate. I. Inhibition of protease activity in in vitro and in vivo experiments. <i>Jpn J Pharmacol <\/i><b>35<\/b>, 203\u2013227."},{"key":"2","doi-asserted-by":"crossref","unstructured":"Cho EY, Choi SC, Lee SH, Ahn JY, Im LR, <i>et al.<\/i> (2011) Nafamostat mesilate attenuates colonic inflammation and mast cell infiltration in the experimental colitis. <i>Int Immunopharmacol <\/i><b>11<\/b>, 412\u2013417.","DOI":"10.1016\/j.intimp.2010.12.008"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Dugina TN, Kiseleva EV, Glusa E and Strukova SM (2003) Activation of mast cells induced by agonists of protease-activated receptors under normal conditions and during acute inflammation in rats. <i>Eur J Pharmacol <\/i><b>471<\/b>, 141\u2013147.","DOI":"10.1016\/S0014-2999(03)01752-7"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Hesketh PJ (2008) Chemotherapy-induced nausea and vomiting. <i>N Engl J Med <\/i><b>358<\/b>, 2482\u20132494.","DOI":"10.1056\/NEJMra0706547"},{"key":"5","unstructured":"Hirafuji M, Minami M, Endo T, Ogawa T, Kato K, <i>et al.<\/i> (2000) Intracellular regulatory mechanisms of 5-HT release from enterochromaffin cells in intestinal mucosa. <i>Biog Amines <\/i><b>16<\/b>, 29\u201352."},{"key":"6","doi-asserted-by":"crossref","unstructured":"Isozaki Y, Yoshida N, Kuroda M, Handa O, Takagi T, <i>et al.<\/i> (2006) Anti-tryptase treatment using nafamostat mesilate has a therapeutic effect on experimental colitis. <i>Scand J Gastroenterol <\/i><b>41<\/b>, 944\u2013953.","DOI":"10.1080\/00365520500529470"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Ju C, Hamaue N, Liu Y, Machida T, Iizuka K, <i>et al.<\/i> (2008) Anti-inflammatory drugs ameliorate an opposite enzymatic change in ileal 5-hydroxytryptamine metabolism in the delayed phase after cisplatin administration to rats. <i>Eur J Pharmacol <\/i><b>589<\/b>, 281\u2013287.","DOI":"10.1016\/j.ejphar.2008.04.050"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Kawabata A, Matsunami M and Sekiguchi F (2008) Gastrointestinal roles for proteinase-activated receptors in health and disease. <i>Brit J Pharmacol <\/i><b>153<\/b>, S230-S240.","DOI":"10.1038\/sj.bjp.0707491"},{"key":"9","unstructured":"Kudo C, Minami M, Hirafuji M, Endo T, Hamaue N, <i>et al.<\/i> (2001) The effects of nabumetone, a cyclooxygenase-2 inhibitor, on cisplatin-induced 5-hydroxytryptamine release from the isolated rat ileum. <i>Res Commun Mol Pathol Pharmacol <\/i><b>110<\/b>, 117\u2013132."},{"key":"10","doi-asserted-by":"crossref","unstructured":"Li Z, Zhang XJ, Xu HX, Sung JJ and Bian ZX (2009) Intracolonical administration of protease-activated receptor-2 agonists produced visceral hyperalgesia by up-regulating serotonin in the colon of rats. <i>Eur J Pharmacol <\/i><b>606<\/b>, 199\u2013204.","DOI":"10.1016\/j.ejphar.2009.01.031"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Margolis KG and Gershon MD (2016) Enteric neuronal regulation of intestinal inflammation. <i>Trends Neurosci <\/i><b>39<\/b>, 614\u2013624.","DOI":"10.1016\/j.tins.2016.06.007"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Minami M, Endo T, Hirafuji M, Hamaue N, Liu Y, <i>et al.<\/i> (2003) Pharmacological aspects of anti-cancer drug-induced emesis with emphasis on serotonin release and vagal nerve activity. <i>Pharmacol Ther <\/i><b>99<\/b>, 149\u2013165.","DOI":"10.1016\/S0163-7258(03)00057-3"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Mori S, Itoh Y, Shinohata R, Sendo T, Oishi R, <i>et al.<\/i> (2003) Nafamostat mesilate is an extremely potent inhibitor of human tryptase. <i>J Pharmacol Sci <\/i><b>92<\/b>, 420\u2013423.","DOI":"10.1254\/jphs.92.420"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Obara Y, Machida T, Takano Y, Shiga S, Suzuki A, <i>et al.<\/i> (2018) Cisplatin increases the number of enterochromaffin cells containing substance P in rat intestine. <i>Naunyn-Schmiedeberg\u2019s Arch Pharmacol <\/i><b>391<\/b>, 847\u2013858.","DOI":"10.1007\/s00210-018-1493-5"},{"key":"15","doi-asserted-by":"crossref","unstructured":"S\u00e9bert M, Sola-Tapias N, Mas E, Barreau F and Ferrand A (2019) Protease-activated receptors in the intestine: Focus on inflammation and cancer. <i>Front Endocrinol <\/i><b>10<\/b>, Article717.","DOI":"10.3389\/fendo.2019.00717"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Takano Y, Machida T, Obara Y, Hirano M, Kudo S, <i>et al.<\/i> (2014) Methotrexate causes a change in intestinal 5-hydroxytryptamine metabolism in rats. <i>Eur J Pharmacol <\/i><b>740<\/b>, 496\u2013503.","DOI":"10.1016\/j.ejphar.2014.06.038"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Vergnolle N (2016) Protease inhibition as new therapeutic strategy for GI diseases. <i>Gut <\/i><b>65<\/b>, 1215\u20131224.","DOI":"10.1136\/gutjnl-2015-309147"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Wingren U, Enerback L, Ahlman H, Allenmark S and Dahlstr\u00f6m A (1983) Amines of the mucosal mast cell of the gut in normal and nematode infected rats. <i>Histochemistry <\/i><b>77<\/b>, 145\u2013158.","DOI":"10.1007\/BF00506557"},{"key":"19","doi-asserted-by":"crossref","unstructured":"<i>Yu PL, Fujimura M, Okuyama K, Kinoshita M, Hasegawa H, <i>et <\/i>al.<\/i> (1999) Immunohistochemical localization of tryptophan hydroxylase in the human and rat gastrointestinal tracts. <i>J Comp Neurol <\/i><b>411<\/b>, 654\u2013665.","DOI":"10.1002\/(SICI)1096-9861(19990906)411:4<654::AID-CNE9>3.0.CO;2-H"}],"container-title":["Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/biomedres\/41\/5\/41_253\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T03:33:21Z","timestamp":1602905601000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/biomedres\/41\/5\/41_253\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,16]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2220\/biomedres.41.253","relation":{},"ISSN":["0388-6107","1880-313X"],"issn-type":[{"value":"0388-6107","type":"print"},{"value":"1880-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,16]]}}}