{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:32:03Z","timestamp":1790253123941,"version":"4.1.0"},"reference-count":31,"publisher":"Biomedical Research Press","issue":"6","funder":[{"DOI":"10.13039\/501100001700","name":"the Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","award":["26462289|15K10487"],"award-info":[{"award-number":["26462289|15K10487"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomed. Res."],"published-print":{"date-parts":[[2022,12,1]]},"DOI":"10.2220\/biomedres.43.211","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T22:10:09Z","timestamp":1670969409000},"page":"211-221","source":"Crossref","is-referenced-by-count":5,"title":["Selective estrogen receptor modulators, acting as agonists of estrogen receptor \u03b1 in osteoblasts, reduce the TGF-\u03b2-induced synthesis of macrophage colony-stimulating factor via inhibition of JNK signaling pathway"],"prefix":"10.2220","volume":"43","author":[{"given":"Tomoyuki","family":"HIOKI","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Gifu University Graduate School of Medicine"},{"name":"Department of Dermatology, Central Japan International Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"MATSUSHIMA-NISHIWAKI","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Gifu University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"TOKUDA","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Gifu University Graduate School of Medicine"},{"name":"Department of Metabolic Research, National Center for Geriatrics and Gerontology"},{"name":"Department of Clinical Laboratory\/Medical Genome Center, National Center for Geriatrics and Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"KOZAWA","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Gifu University Graduate School of Medicine"},{"name":"Department of Metabolic Research, National Center for Geriatrics and Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1059","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"An K (2016) Selective estrogen receptor modulators. <i>Asian Spine J <\/i>10, 787-791<i>.<\/i>","DOI":"10.4184\/asj.2016.10.4.787"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Amarasekara DS, Yun H, Kim S, Lee N, Kim H, <i>et al.<\/i> (2018) Regulation of osteoclast differentiation by cytokine networks. <i>Immune Netw<\/i> 18, e8.","DOI":"10.4110\/in.2018.18.e8"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Doi T, Hioki T, Tachi J, Ueda K, Matsushima-Nishiwaki R, <i>et al.<\/i> (2022) Oncostatin M reduces the synthesis of macrophage- colony stimulating factor stimulated by TGF-\u03b2 via suppression of p44\/p42 MAP kinase and JNK in osteoblasts. <i>Biomed Res<\/i> (Tokyo) 43, 41\u201351.","DOI":"10.2220\/biomedres.43.41"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Fixe P and Praloran V (1998) M-CSF: haematopoietic growth factor or inflammatory cytokine? <i>Cytokine<\/i> 10, 32\u201337.","DOI":"10.1006\/cyto.1997.0249"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Harris HA, Albert LM, Leathurby Y, Malamas MS, Mewshaw RE, <i>et al.<\/i> (2003) Evaluation of an estrogen receptor-\u03b2 agonist in animal models of human disease. <i>Endocrinology<\/i> 144, 4241\u20134249.","DOI":"10.1210\/en.2003-0550"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Kanazawa I, Tomita T, Miyazaki S, Ozawa E, <i>et al.<\/i> (2017) Bazedoxifene ameliorates homocysteine-induced apoptosis and accumulation of advanced glycation end products by reducing oxidative stress in MC3T3-E1 cells. <i>Calcif Tissue Int<\/i> 100, 286\u2013297.","DOI":"10.1007\/s00223-016-0211-x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Karsenty G and Wangner EF (2002) Reaching a genetic and molecular understanding of skeletal development. <i>Dev Cell<\/i> 2, 389\u2013406.","DOI":"10.1016\/S1534-5807(02)00157-0"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Kato K, Ito H, Hasegawa K, Inaguma Y, Kozawa O, <i>et al.<\/i> (1996) Modulation of the stress-induced synthesis of hsp27 and \u03b1B-crystallin by cyclic AMP in C6 rat glioma cells. <i>J Neurochem<\/i> 66, 946\u2013950.","DOI":"10.1046\/j.1471-4159.1996.66030946.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Khalid AB and Krum SA (2016) Estrogen receptors \u03b1 and \u03b2 in bone. <i>Bone<\/i> 87, 130\u2013135.","DOI":"10.1016\/j.bone.2016.03.016"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Kim JM, Lin C, Stavre Z, Greenblatt MB and Shim JH (2020) Osteoblast-osteoclast communication and bone homeostasis. <i>Cells 9, <\/i>2073.","DOI":"10.3390\/cells9092073"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Kozawa O, Tokuda H, Miwa M, Kotoyori J and Oiso Y (1992) Cross-talk regulation between cyclic AMP production and phosphoinositide hydrolysis induced by prostaglandin E2 in osteoblast-like cells. <i>Exp Cell Res<\/i> 198, 130\u2013134.","DOI":"10.1016\/0014-4827(92)90158-5"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Kular J, Tickner J, Chim SM and Xu J (2012) An overview of the regulation of bone remodeling at the cellular level. <i>Clin Biochem<\/i> 45, 863\u2013873.","DOI":"10.1016\/j.clinbiochem.2012.03.021"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. <i>Nature<\/i> 227, 680\u2013685.","DOI":"10.1038\/227680a0"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Martinkovich S, Shah D, Planey SL and Arnott JA (2014) Selective estrogen receptor modulators: tissue specificity and clinical utility. <i>Clin Interv Aging<\/i> 9, 1437\u20131452.","DOI":"10.2147\/CIA.S66690"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Maximov PY, Lee TM and Jordan VC (2013) The discovery and development of selective estrogen receptor modulators (SERMs) for clinical practice. <i>Curr Clin Pharmacol<\/i> 8, 135\u2013 155.","DOI":"10.2174\/1574884711308020006"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Morikawa M, Derynck R and Miyazono K (2016) TGF-\u03b2 and the TGF-\u03b2 family: context-dependent roles in cell and tissue physiology. <i>Cold Spring Harb Perspect Biol<\/i> 8, a021873.","DOI":"10.1101\/cshperspect.a021873"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Moustakas A and Heldin CH (2005) Non-Smad TGF-\u03b2 signals. <i>J Cell Sci<\/i> 118, 3573\u20133584.","DOI":"10.1242\/jcs.02554"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Olivier S, Fillet M, Malaise M, Piette J, Bours V, <i>et al.<\/i> (2005) Sodium nitroprusside-induced osteoblast apoptosis is mediated by long chain ceramide and is decreased by raloxifene. <i>Biochem Pharmacol<\/i> 69, 891\u2013901.","DOI":"10.1016\/j.bcp.2004.11.030"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Pinkerton JV and Thomas S (2014) Use of SERMs for treatment in postmenopausal women. <i>J Steroid Biochem Mol Biol<\/i> 142, 142\u2013154.","DOI":"10.1016\/j.jsbmb.2013.12.011"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Sinder BP, Pettit AR and McCauley LK (2015) Macrophages: their emerging roles in bone. <i>J Bone Miner Res<\/i> 30, 2140\u2013 2149.","DOI":"10.1002\/jbmr.2735"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Stauffer SR, Coletta CJ, Tadesco R, Nishiguchi K, Carlson K, <i>et al.<\/i> (2000) Pyrazole ligands: structure-affinity\/activity relationships and estrogen receptor-\u03b1-selective agonists. <i>J Med Chem<\/i> 43, 4934-4947.","DOI":"10.1021\/jm000170m"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Sudo H, Kodama H, Amagai Y, Yamamoto S and Kasai S (1983) In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. <i>J Cell Biol<\/i> 96, 191\u2013198.","DOI":"10.1083\/jcb.96.1.191"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Sun J, Huang YR, Harrington WR, Sheng S, Katzenellenbogen JA, <i>et al.<\/i> (2000) Antagonists selective for estrogen receptor \u03b1. <i>Endocrinology<\/i> 143, 941\u2013947.","DOI":"10.1210\/endo.143.3.8704"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Takaishi T, Matsui T, Tsukamoto T, Ito M, Taniguchi T, <i>et al.<\/i> (1994) TGF-\u03b2-induced macrophage colony-stimulating factor gene expression in various mesenchymal cell lines. <i>Am J Physiol<\/i> 267, C25\u201331.","DOI":"10.1152\/ajpcell.1994.267.1.C25"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Tang Y, Wu X, Lei W, Pang L, Wan C, <i>et al.<\/i> (2009) TGF-\u03b21-induced migration of bone mesenchymal stem cells couples bone resorption with formation. <i>Nat Med<\/i> 15, 757\u2013765.","DOI":"10.1038\/nm.1979"},{"key":"26","doi-asserted-by":"crossref","unstructured":"ten Dijke P and Hill CS (2004) New insights into TGF-\u03b2-Smad signalling. <i>Trends Biochem Sci<\/i> 29, 265\u2013273.","DOI":"10.1016\/j.tibs.2004.03.008"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Theoleyres S, Wittrant Y, Tat SK, Fortun Y, Redini F, <i>et al.<\/i> (2004) The molecular triad OPG\/RANK\/RANKL: involvement in the orchestration of pathophysiological bone remodeling. <i>Cytokine Growth Factor Rev<\/i> 15, 457\u2013475.","DOI":"10.1016\/j.cytogfr.2004.06.004"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Walsh MC, Kim N, Kadono Y, Rho J, Lee SY,<i> et al.<\/i> (2006) Osteoimmunology: interplay between the immune system and bone metabolism. <i>Annu Rev Immunol<\/i> 24, 33\u201363.","DOI":"10.1146\/annurev.immunol.24.021605.090646"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Wang G, Xu W, Zhang J, Tang T, Chen J, <i>et al.<\/i> (2017) Induction of bone remodeling by raloxifene-doped iron oxide functionalized with hydroxyapatite to accelerate fracture healing. <i>J Biomed Nanotechnol<\/i> 17, 932-941.","DOI":"10.1166\/jbn.2021.3068"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Xu B, Lovre D and Mauvais-Jarvis F (2017) The effect of selective estrogen receptor modulators on type 2 diabetes onset in women: Basic and clinical insights. <i>J Diabetes Complications<\/i> 31, 773\u2013779.","DOI":"10.1016\/j.jdiacomp.2016.12.010"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Zuo C, Huang Y, Bajis R, Sahih M, Li YP, <i>et al.<\/i> (2012) Osteoblastogenesis regulation signals in bone remodeling. <i>Osteoporos Int<\/i> 23, 1653\u20131663.","DOI":"10.1007\/s00198-012-1909-x"}],"container-title":["Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/biomedres\/43\/6\/43_211\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T04:30:18Z","timestamp":1715315418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/biomedres\/43\/6\/43_211\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.2220\/biomedres.43.211","relation":{},"ISSN":["0388-6107","1880-313X"],"issn-type":[{"value":"0388-6107","type":"print"},{"value":"1880-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,1]]}}}