{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:12:09Z","timestamp":1790241129596,"version":"4.1.0"},"reference-count":0,"publisher":"Forum Multimedia Publishing LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["eCM"],"abstract":"<jats:p>Implant infection impairs osseointegration of orthopaedic implants by inducing inflammation. Acinetobacter spp. are increasingly prevalent multi-drug resistant bacteria that can cause osteomyelitis. Acinetobacter spp. can also cause inflammation and thereby inhibit osseointegration in mice. The purpose of the present study was to investigate the role of quorum sensing in this context. Therefore, wild-type bacteria were compared with an isogenic abaI mutant defective in quorum sensing in a murine osseointegration model. The abaI quorum- sensing mutant affected significantly less osseointegration and interleukin (IL) 1\u03b2 levels, without detectably altering other pro-inflammatory cytokines. Wild-type bacteria had fewer effects on IL1 receptor (IL1R)\u2212\/\u2212 mice. These results indicated that quorum sensing in Acinetobacter spp. contributed to IL1\u03b2 induction and the resultant inhibition of osseointegration in mice. Moreover, targeting the Gram-negative acyl-homoserine lactone quorum sensing may be particularly effective for patients with Acinetobacter spp. infections.<\/jats:p>","DOI":"10.22203\/ecm.v043a18","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T10:49:55Z","timestamp":1654771795000},"page":"267-276","source":"Crossref","is-referenced-by-count":3,"title":["Acinetobacter quorum sensing contributes to inflammation-induced inhibition of orthopaedic implant osseointegration"],"prefix":"10.22203","volume":"43","author":[{"name":"Department of Orthopaedic Surgery, Indiana University School of Medicine, Medical Sciences Building, Room 371, 635 Barnhill Drive, Indianapolis, IN, 46202, USA E-mail: egreenf at iu.edu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Choe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BS","family":"Hausman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KM","family":"Hujer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Akkus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PN","family":"Rather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RA","family":"Bonomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EM","family":"Greenfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"39461","published-online":{"date-parts":[[2022,6,9]]},"container-title":["European Cells and Materials"],"original-title":[],"link":[{"URL":"https:\/\/www.ecmjournal.org\/papers\/vol043\/pdf\/v043a18.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:48:14Z","timestamp":1790239694000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ecmjournal.org\/journal\/ECM\/path\/vol043\/10.22203\/eCM.v043a18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22203\/ecm.v043a18","relation":{},"subject":[],"published":{"date-parts":[[2022,6,9]]}}}