{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:48:10Z","timestamp":1791373690522,"version":"4.3.1"},"reference-count":0,"publisher":"Forum Multimedia Publishing LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["eCM"],"abstract":"<jats:p>Prior studies have outlined C-reactive protein (CRP) within the first 5 d following total hip arthroplasty (THA) as an inappropriate indicator of an early periprosthetic joint infection (PJI). Recently, interleukin-6 (IL-6), as a potential inflammatory marker following total joint arthroplasty (TJA), has gained increasing interest, particularly due to its considerably shorter half-life. The aim of the present study was to assess IL-6 measured on postoperative day 3 following TJA as a prediction marker of early onset PJI. 7,661 patients, who underwent total hip or knee arthroplasty (THA, TKA) at a single institution between 2016 and 2019, were evaluated. Serum IL-6 values were measured on postoperative day 3 and compared between patients, with and without early onset PJI in the postoperative follow-up, matched for age, gender, Surgical Site Infection Risk Score and Charlson comorbidity index. Overall (n = 7,661), there was no statistically significant difference in serum IL-6 levels comparing patients with and without early onset PJI following THA [38.9 pg\/ mL vs. 32.0 pg\/mL, p = 0.116] and TKA [30.6 pg\/mL vs. 28.2 pg\/mL, p = 0.718]. Male gender and high body mass index were associated with an increased risk of early onset PJI following THA (p = 0.027, p = 0.002). Matched cohort analysis (n = 86) showed no statistically significant difference in serum IL-6 levels between patients with and without early onset PJI following THA (p = 0.680) and TKA (p = 0.910). Serum IL-6 values on postoperative day 3 following THA or TKA could not predict early onset PJIs.<\/jats:p>","DOI":"10.22203\/ecm.v043a20","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T06:21:56Z","timestamp":1656397316000},"page":"293-298","source":"Crossref","is-referenced-by-count":5,"title":["Postoperative IL-6 levels cannot predict early onset periprosthetic hip\/knee infections: an analysis of 7,661 patients at a single institution"],"prefix":"10.22203","volume":"43","author":[{"given":"A","family":"Aichmair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BJH","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Skolek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dominkus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JG","family":"Hofstaetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"39461","published-online":{"date-parts":[[2022,6,28]]},"container-title":["European Cells and Materials"],"original-title":[],"link":[{"URL":"https:\/\/www.ecmjournal.org\/papers\/vol043\/pdf\/v043a20.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:48:15Z","timestamp":1790239695000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ecmjournal.org\/journal\/ECM\/path\/vol043\/10.22203\/eCM.v043a20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22203\/ecm.v043a20","relation":{},"subject":[],"published":{"date-parts":[[2022,6,28]]}}}