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Pathogenic flaviviruses. Lancet 371: 500-9.2008.","DOI":"10.1016\/S0140-6736(08)60238-X"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Hollidge BS, Gonzalez-Scarano F, Soldan SS. Arboviral encephalitides: transmission, emergence, and pathogenesis. J Neuroimmune Pharmacol 5: 428-42.2010.","DOI":"10.1007\/s11481-010-9234-7"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Wilson MR. Emerging viral infections. Curr Opin Neurol 26: 301-6.2013.","DOI":"10.1097\/WCO.0b013e328360dd2b"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Ergunay K, Tkachev S, Kozlova I, Ruzek D. A Review of Methods for Detecting Tick-Borne Encephalitis Virus Infection in Tick, Animal, and Human Specimens. Vector borne and zoonotic diseases 16: 4-12.2016.","DOI":"10.1089\/vbz.2015.1896"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Lindquist L. Tick-borne encephalitis. Handb Clin Neurol 123: 531-59.2014.","DOI":"10.1016\/B978-0-444-53488-0.00025-0"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Heinz FX, Mandl CW. The molecular biology of tick-borne encephalitis virus. Review article. APMIS 101: 735-45.1993.","DOI":"10.1111\/j.1699-0463.1993.tb00174.x"},{"key":"7","unstructured":"7) Slavik I, Mrena E, Mayer V. Studies on Tick-borne encephalitis virus. II. Virus morphology and some data on virus structure. Acta Virol 14: 8-16.1970."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Stadler K, Allison SL, Schalich J, Heinz FX. Proteolytic activation of tick-borne encephalitis virus by furin. J Virol 71: 8475-81.1997.","DOI":"10.1128\/JVI.71.11.8475-8481.1997"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Elshuber S, Allison SL, Heinz FX, Mandl CW. Cleavage of protein prM is necessary for infection of BHK-21 cells by tick-borne encephalitis virus. J Gen Virol 84: 183-91.2003.","DOI":"10.1099\/vir.0.18723-0"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Allison SL, Schalich J, Stiasny K, Mandl CW, Kunz C, Heinz FX. Oligomeric rearrangement of tick-borne encephalitis virus envelope proteins induced by an acidic pH. J Virol 69: 695-700.1995.","DOI":"10.1128\/JVI.69.2.695-700.1995"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Wengler G. Cell-associated West Nile flavivirus is covered with E+pre-M protein heterodimers which are destroyed and reorganized by proteolytic cleavage during virus release. J Virol 63: 2521-6.1989.","DOI":"10.1128\/JVI.63.6.2521-2526.1989"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Lorenz IC, Allison SL, Heinz FX, Helenius A. Folding and dimerization of tick-borne encephalitis virus envelope proteins prM and E in the endoplasmic reticulum. J Virol 76: 5480-91.2002.","DOI":"10.1128\/JVI.76.11.5480-5491.2002"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Mandl CW. Steps of the tick-borne encephalitis virus replication cycle that affect neuropathogenesis. Virus research 111: 161-74.2005.","DOI":"10.1016\/j.virusres.2005.04.007"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Muller DA, Young PR. The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker. Antiviral Res 98: 192-208.2013.","DOI":"10.1016\/j.antiviral.2013.03.008"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kroschewski H, Allison SL, Heinz FX, Mandl CW. Role of heparan sulfate for attachment and entry of tick-borne encephalitis virus. Virology 308: 92-100.2003.","DOI":"10.1016\/S0042-6822(02)00097-1"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Demina TV, Dzhioev YP, Verkhozina MM, Kozlova IV, Tkachev SE, Plyusnin A, Doroshchenko EK, Lisak OV, Zlobin VI. Genotyping and characterization of the geographical distribution of tick-borne encephalitis virus variants with a set of molecular probes. J Med Virol 82: 965-76.2010.","DOI":"10.1002\/jmv.21765"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Suss J. Tick-borne encephalitis 2010: epidemiology, risk areas, and virus strains in Europe and Asia-an overview. Ticks and tick-borne diseases 2: 2-15.2011.","DOI":"10.1016\/j.ttbdis.2010.10.007"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Takeda T, Ito T, Chiba M, Takahashi K, Niioka T, Takashima I. Isolation of tick-borne encephalitis virus from Ixodes ovatus (Acari: Ixodidae) in Japan. Journal of medical entomology 35: 227-31.1998.","DOI":"10.1093\/jmedent\/35.3.227"},{"key":"19","unstructured":"19) Lichard M, Kozuch O. Persistence of tick-borne encephalitis virus in nymphs and adults of Ixodes arboricola and its transmission to white mice. Acta Virol 11: 480.1967."},{"key":"20","unstructured":"20) Kozuch O, Nosek J. Transmission of tick-borne encephalitis (TBE) virus by Dermacentor marginatus and D. reticulatus ticks. Acta Virol 15: 334.1971."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Yun SM, Lee YJ, Choi W, Kim HC, Chong ST, Chang KS, Coburn JM, Klein TA, Lee WJ. Molecular detection of severe fever with thrombocytopenia syndrome and tick-borne encephalitis viruses in ixodid ticks collected from vegetation, Republic of Korea, 2014. Ticks and tick-borne diseases 7: 970-978.2016.","DOI":"10.1016\/j.ttbdis.2016.05.003"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Danielova V, Daniel M, Schwarzova L, Materna J, Rudenko N, Golovchenko M, Holubova J, Grubhoffer L, Kilian P. Integration of a tick-borne encephalitis virus and Borrelia burgdorferi sensu lato into mountain ecosystems, following a shift in the altitudinal limit of distribution of their vector, Ixodes ricinus (Krkonose mountains, Czech Republic). Vector borne and zoonotic diseases 10: 223-30.2010.","DOI":"10.1089\/vbz.2009.0020"},{"key":"23","unstructured":"23) Radda A, Hofmann H, Pretzmann G. Threshold of viraemia in Apodemus flavicollis for infection of Ixodes ricinus with tick-borne encephalitis virus. Acta Virol 13: 74-7.1969."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Rosa R, Pugliese A, Norman R, Hudson PJ. Thresholds for disease persistence in models for tick-borne infections including non-viraemic transmission, extended feeding and tick aggregation. J Theor Biol 224: 359-76.2003.","DOI":"10.1016\/S0022-5193(03)00173-5"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Labuda M, Austyn JM, Zuffova E, Kozuch O, Fuchsberger N, Lysy J, Nuttall PA. Importance of localized skin infection in tick-borne encephalitis virus transmission. Virology 219: 357-66.1996.","DOI":"10.1006\/viro.1996.0261"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Bogovic P, Strle F. Tick-borne encephalitis: A review of epidemiology, clinical characteristics, and management. World J Clin Cases 3: 430-41.2015.","DOI":"10.12998\/wjcc.v3.i5.430"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Suss J. Tick-borne encephalitis in Europe and beyond--the epidemiological situation as of 2007. Euro Surveill 13.2008.","DOI":"10.2807\/ese.13.26.18916-en"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Kim SY, Jeong YE, Yun SM, Lee IY, Han MG, Ju YR. Molecular evidence for tick-borne encephalitis virus in ticks in South Korea. Medical and veterinary entomology 23: 15-20.2009.","DOI":"10.1111\/j.1365-2915.2008.00755.x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Kaiser R. Tick-borne encephalitis. Infect Dis Clin North Am 22: 561-75, x.2008.","DOI":"10.1016\/j.idc.2008.03.013"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Mickiene A, Laiskonis A, Gunther G, Vene S, Lundkvist A, Lindquist L. Tickborne encephalitis in an area of high endemicity in lithuania: disease severity and long-term prognosis. Clin Infect Dis 35: 650-8.2002.","DOI":"10.1086\/342059"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Dorrbecker B, Dobler G, Spiegel M, Hufert FT. Tick-borne encephalitis virus and the immune response of the mammalian host. Travel Med Infect Dis 8: 213-22.2010.","DOI":"10.1016\/j.tmaid.2010.05.010"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Gunther G, Haglund M, Lindquist L, Forsgren M, Skoldenberg B. Tick-bone encephalitis in Sweden in relation to aseptic meningo-encephalitis of other etiology: a prospective study of clinical course and outcome. J Neurol 244: 230-8.1997.","DOI":"10.1007\/s004150050077"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Logar M, Bogovic P, Cerar D, Avsic-Zupanc T, Strle F. Tick-borne encephalitis in Slovenia from 2000 to 2004: comparison of the course in adult and elderly patients. Wien Klin Wochenschr 118: 702-7.2006.","DOI":"10.1007\/s00508-006-0699-6"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Broker M, Kollaritsch H. After a tick bite in a tick-borne encephalitis virus endemic area: current positions about post-exposure treatment. Vaccine 26: 863-8.2008.","DOI":"10.1016\/j.vaccine.2007.11.046"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Heinz FX, Holzmann H, Essl A, Kundi M. Field effectiveness of vaccination against tick-borne encephalitis. Vaccine 25: 7559-67.2007.","DOI":"10.1016\/j.vaccine.2007.08.024"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Chiba N, Osada M, Komoro K, Mizutani T, Kariwa H, Takashima I. Protection against tick-borne encephalitis virus isolated in Japan by active and passive immunization. Vaccine 17: 1532-9.1999.","DOI":"10.1016\/S0264-410X(98)00360-0"},{"key":"37","unstructured":"37) Ando K, Kuratsuka K, Arima S, Hironaka N, Honda Y, Ishii K. Studies on the viruses isolated during epidemic of Japanese B encephalitis in 1948 in Tokyo area. Kitasato Arch Exp Med 24: 557-62; English transl 429-41.1952."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Venugopal K, Buckley A, Reid HW, Gould EA. Nucleotide sequence of the envelope glycoprotein of Negishi virus shows very close homology to louping ill virus. Virology 190: 515-21.1992.","DOI":"10.1016\/0042-6822(92)91245-P"},{"key":"39","unstructured":"39) Morita K, Igarashi A, Sato T, Takezawa T. A suspected case of tick-borne encephalitis in Hokkaido. Infectious Agents Surveillance Report 15.1994."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Takashima I, Morita K, Chiba M, Hayasaka D, Sato T, Takezawa C, Igarashi A, Kariwa H, Yoshimatsu K, Arikawa J, Hashimoto N. A case of tick-borne encephalitis in Japan and isolation of the the virus. Journal of clinical microbiology 35: 1943-7.1997.","DOI":"10.1128\/JCM.35.8.1943-1947.1997"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Takeda T, Ito T, Osada M, Takahashi K, Takashima I. Isolation of tick-borne encephalitis virus from wild rodents and a seroepizootiologic survey in Hokkaido, Japan. The American journal of tropical medicine and hygiene 60: 287-91.1999.","DOI":"10.4269\/ajtmh.1999.60.287"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Kentaro Y, Yamazaki S, Mottate K, Nagata N, Seto T, Sanada T, Sakai M, Kariwa H, Takashima I. Genetic and biological characterization of tick-borne encephalitis virus isolated from wild rodents in southern Hokkaido, Japan in 2008. Vector borne and zoonotic diseases 13: 406-14.2013.","DOI":"10.1089\/vbz.2012.1231"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Yoshii K, Mottate K, Omori-Urabe Y, Chiba Y, Seto T, Sanada T, Maeda J, Obara M, Ando S, Ito N, Sugiyama M, Sato H, Fukushima H, Kariwa H, Takashima I. Epizootiological study of tick-borne encephalitis virus infection in Japan. The Journal of veterinary medical science \/ the Japanese Society of Veterinary Science 73: 409-12.2011.","DOI":"10.1292\/jvms.10-0350"},{"key":"44","unstructured":"44) Yoshii K, Tajima Y, Bando K, Moriuchi R. A confirmed case of tick-borne encephalitis in Hokkaido in 2016. Infectious Agents Surveillance Report 38: 126.2016."},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Puchhammer-Stockl E, Kunz C, Mandl CW, Heinz FX. Identification of tick-borne encephalitis virus ribonucleic acid in tick suspensions and in clinical specimens by a reverse transcription-nested polymerase chain reaction assay. Clin Diagn Virol 4: 321-6.1995.","DOI":"10.1016\/0928-0197(95)00022-4"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Saksida A, Duh D, Lotric-Furlan S, Strle F, Petrovec M, Avsic-Zupanc T. The importance of tick-borne encephalitis virus RNA detection for early differential diagnosis of tick-borne encephalitis. J Clin Virol 33: 331-5.2005.","DOI":"10.1016\/j.jcv.2004.07.014"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Holzmann H, Kundi M, Stiasny K, Clement J, McKenna P, Kunz C, Heinz FX. Correlation between ELISA, hemagglutination inhibition, and neutralization tests after vaccination against tick-borne encephalitis. J Med Virol 48: 102-7.1996.","DOI":"10.1002\/(SICI)1096-9071(199601)48:1<102::AID-JMV16>3.3.CO;2-Q"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Yoshii K, Hayasaka D, Goto A, Obara M, Araki K, Yoshimatsu K, Arikawa J, Ivanov L, Mizutani T, Kariwa H, Takashima I. Enzyme-linked immunosorbent assay using recombinant antigens expressed in mammalian cells for serodiagnosis of tick-borne encephalitis. Journal of virological methods 108: 171-9.2003.","DOI":"10.1016\/S0166-0934(02)00283-5"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Inagaki E, Sakai M, Hirano M, Muto M, Kobayashi S, Kariwa H, Yoshii K. Development of a serodiagnostic multi-species ELISA against tick-borne encephalitis virus using subviral particles. Ticks and tick-borne diseases 7: 723-9.2016.","DOI":"10.1016\/j.ttbdis.2016.03.002"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Obara M, Yoshii K, Kawata T, Hayasaka D, Goto A, Mizutani T, Kariwa H, Takashima I. Development of an enzyme-linked immunosorbent assay for serological diagnosis of tick-borne encephalitis using subviral particles. Journal of virological methods 134: 55-60.2006.","DOI":"10.1016\/j.jviromet.2005.11.018"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Chiba N, Iwasaki T, Mizutani T, Kariwa H, Kurata T, Takashima I. Pathogenicity of tick-borne encephalitis virus isolated in Hokkaido, Japan in mouse model. Vaccine 17: 779-87.1999.","DOI":"10.1016\/S0264-410X(98)00262-X"},{"key":"52","unstructured":"52) Goto A, Hayasaka D, Yoshii K, Mizutani T, Kariwa H, Takashima I. Genetic and biological comparison of tick-borne encephalitis viruses from Hokkaido and far-eastern Russia. The Japanese journal of veterinary research 49: 297-307.2002."},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Takano A, Yoshii K, Omori-Urabe Y, Yokozawa K, Kariwa H, Takashima I. Construction of a replicon and an infectious cDNA clone of the Sofjin strain of the Far-Eastern subtype of tick-borne encephalitis virus. Archives of virology 156: 1931-41.2011.","DOI":"10.1007\/s00705-011-1066-0"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Hayasaka D, Gritsun TS, Yoshii K, Ueki T, Goto A, Mizutani T, Kariwa H, Iwasaki T, Gould EA, Takashima I. Amino acid changes responsible for attenuation of virus neurovirulence in an infectious cDNA clone of the Oshima strain of tick-borne encephalitis virus. J Gen Virol 85: 1007-18.2004.","DOI":"10.1099\/vir.0.19668-0"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Sakai M, Muto M, Hirano M, Kariwa H, Yoshii K. Virulence of tick-borne encephalitis virus is associated with intact conformational viral RNA structures in the variable region of the 3'-UTR. Virus research 203: 36-40.2015.","DOI":"10.1016\/j.virusres.2015.03.006"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Formanova P, Cerny J, Bolfikova BC, Valdes JJ, Kozlova I, Dzhioev Y, Ruzek D. Full genome sequences and molecular characterization of tick-borne encephalitis virus strains isolated from human patients. Ticks and tick-borne diseases 6: 38-46.2015.","DOI":"10.1016\/j.ttbdis.2014.09.002"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Mandl CW, Holzmann H, Meixner T, Rauscher S, Stadler PF, Allison SL, Heinz FX. Spontaneous and engineered deletions in the 3' noncoding region of tick-borne encephalitis virus: construction of highly attenuated mutants of a flavivirus. J Virol 72: 2132-40.1998.","DOI":"10.1128\/JVI.72.3.2132-2140.1998"}],"container-title":["Uirusu"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jsv\/67\/2\/67_143\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T14:21:09Z","timestamp":1662301269000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jsv\/67\/2\/67_143\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,25]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.2222\/jsv.67.143","relation":{},"ISSN":["0042-6857","1884-3433"],"issn-type":[{"value":"0042-6857","type":"print"},{"value":"1884-3433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,25]]}}}