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Nat Rev Cancer 2007; 7: 270-280.","DOI":"10.1038\/nrc2111"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5\uff09\tBangham CRM, Matsuoka M. Human T-cell leukaemia virus type 1: parasitism and pathogenesis. Philos Trans R Soc Lond B Biol Sci 2017; 372.","DOI":"10.1098\/rstb.2016.0272"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6\uff09\tUchiyama T, Yodoi J, Sagawa K et al. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood 1977; 50: 481-492.","DOI":"10.1182\/blood.V50.3.481.481"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7\uff09\tTakatsuki K. Discovery of adult T-cell leukemia. Retrovirology 2005; 2: 16.","DOI":"10.1186\/1742-4690-2-16"},{"key":"8","doi-asserted-by":"crossref","unstructured":"9\uff09\tTajima K. The 4th nation-wide study of adult T-cell leukemia\/lymphoma (ATL) in Japan: estimates of risk of ATL and its geographical and clinical features. The T- and B-cell Malignancy Study Group. Int J Cancer 1990; 45: 237-243.","DOI":"10.1002\/ijc.2910450206"},{"key":"9","doi-asserted-by":"crossref","unstructured":"10\uff09\tWatanabe T. Current status of HTLV-1 infection. Int J Hematol 2011; 94: 430-434.","DOI":"10.1007\/s12185-011-0934-4"},{"key":"10","doi-asserted-by":"crossref","unstructured":"11\uff09\tSatake M, Iwanaga M, Sagara Y et al. Incidence of human T-lymphotropic virus 1 infection in adolescent and adult blood donors in Japan: a nationwide retrospective cohort analysis. Lancet Infect Dis 2016; 16: 1246-1254.","DOI":"10.1016\/S1473-3099(16)30252-3"},{"key":"11","doi-asserted-by":"crossref","unstructured":"12\uff09\tNosaka K, Iwanaga M, Imaizumi Y et al. Epidemiological and clinical features of adult T-cell leukemia-lymphoma in Japan, 2010-2011: A nationwide survey. Cancer Sci 2017; 108: 2478-2486.","DOI":"10.1111\/cas.13398"},{"key":"12","doi-asserted-by":"crossref","unstructured":"13\uff09\tVose J, Armitage J, Weisenburger D. International peripheral T-cell and natural killer\/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 2008; 26: 4124-4130.","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"13","unstructured":"14\uff09\tGessain A, Cassar O. Epidemiological Aspects and World Distribution of HTLV-1 Infection. Front Microbiol 2012; 3: 388."},{"key":"14","doi-asserted-by":"crossref","unstructured":"15\uff09\tChihara D, Ito H, Matsuda T et al. Differences in incidence and trends of haematological malignancies in Japan and the United States. Br J Haematol 2014; 164: 536-545.","DOI":"10.1111\/bjh.12659"},{"key":"15","doi-asserted-by":"crossref","unstructured":"16\uff09\tTsukasaki K, Utsunomiya A, Fukuda H et al. VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801. 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Leukemia 2017; 31: 2235-2243.","DOI":"10.1038\/leu.2017.74"},{"key":"85","doi-asserted-by":"crossref","unstructured":"86\uff09\tNakagawa M, Shaffer AL, 3rd, Ceribelli M et al. Targeting the HTLV-I-Regulated BATF3\/IRF4 Transcriptional Network in Adult T Cell Leukemia\/Lymphoma. Cancer Cell 2018; 34: 286-297.e210.","DOI":"10.1016\/j.ccell.2018.06.014"},{"key":"86","doi-asserted-by":"crossref","unstructured":"87\uff09\tLi P, Spolski R, Liao W et al. BATF-JUN is critical for IRF4-mediated transcription in T cells. 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