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We demonstrate that initializing a hardware-efficient, Floquet-structured ansatz within the many-body localized (MBL) phase mitigates barren plateaus and enhances algorithmic trainability. Through analysis of the inverse participation ratio, entanglement entropy, and a novel low-weight stabilizer R\u00e9nyi entropy, we characterize a distinct MBL--thermalization transition. Below a critical kick strength, the circuit avoids forming a unitary 2-design, exhibits robust area-law entanglement, and maintains non-vanishing gradients. Leveraging this MBL regime facilitates the efficient variational preparation of ground states for several model Hamiltonians with significantly reduced computational resources. Crucially, experiments on a 127-qubit superconducting processor provide evidence for the preservation of trainable gradients in the MBL phase for a kicked Heisenberg chain, validating our approach on contemporary noisy hardware. Our findings position MBL-based initialization as a viable strategy for developing scalable VQAs and motivate broader integration of localization into quantum algorithm design.<\/jats:p>","DOI":"10.22331\/q-2025-12-12-1942","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T15:17:26Z","timestamp":1765552646000},"page":"1942","update-policy":"https:\/\/doi.org\/10.22331\/q-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Exploiting many-body localization for scalable variational quantum simulation"],"prefix":"10.22331","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5589-7503","authenticated-orcid":false,"given":"Chenfeng","family":"Cao","sequence":"first","affiliation":[{"name":"HK Institute of Quantum Science $\\&$ Technology, The University of Hong Kong, Hong Kong, China"},{"name":"Dahlem Center for Complex Quantum Systems, Freie Universit\u00e4t Berlin, 14195 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Wisconsin-Madison, Madison, WI 53706, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swamit","family":"Tannu","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Wisconsin-Madison, Madison, WI 53706, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nic","family":"Shannon","sequence":"additional","affiliation":[{"name":"Theory of Quantum Matter Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0412, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Joynt","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Wisconsin-Madison, Madison, WI 53706, USA"},{"name":"Theoretical Sciences Visiting Program (TSVP), Okinawa Institute of Science and Technology Graduate University, Onna, 904-0495, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9598","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"0","doi-asserted-by":"publisher","unstructured":"Alberto Peruzzo, Jarrod McClean, Peter Shadbolt, Man-Hong Yung, Xiao-Qi Zhou, Peter J. 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