{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:52:56Z","timestamp":1789764776722,"version":"4.0.1"},"reference-count":0,"publisher":"Codon Publications","issue":"1","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Popl Ther Clin Pharmacol"],"abstract":"<jats:p>Background\r\nAutoimmune arthritic diseases affect many women of child-bearing age. Tumour necrosis factor (TNF)-\u03b1 inhibitors are currently used for the treatment of various immune-mediated diseases during pregnancy. However, there has been no evaluation of safety in the treatment of arthritic diseases during gestation.\r\nObjective\r\nTo analyze the risk of adverse pregnancy and neonatal outcomes after treatment of arthritic diseases with TNF-\u03b1 inhibitors.\r\nMethods\r\nMajor databases including Ovid MEDLINE, Embase, and Web of Science, were searched inclusive to April 2016. Observational prospective cohort studies evaluating pregnancy outcomes (birth defects, Spontaneous abortion, therapeutic abortion, birth weight, preterm birth, live birth) after exposure to TNF-\u03b1 inhibitors for the treatment of arthritic diseases during pregnancy were included. Data on pregnancy and neonatal outcomes was extracted from all included studies. A meta-analysis was performed using inverse-variance random effect with a 95% confidence interval (95%CI) and p&lt;0.05.\r\nResults\r\nEight prospective studies with comparison groups were included in the meta-analysis. TNF-\u03b1 inhibitors were associated with significantly higher risks of low birth weight (odds ratio (OR), 1.43; 95%CI, 1.00\u20132.04) and significantly lower rates of live birth (OR, 0.61; 95%CI, 0.38\u20130.98). However, birth defects, therapeutic abortion, spontaneous abortion, and preterm birth were not significantly different between the 2 groups.\r\nConclusion\r\nTreatment of arthritic diseases with TNF-\u03b1 inhibitors during pregnancy increases the risk of lower birth weight and decreases the rate of live birth in this population. While duration of treatment and gestational age at exposure may play a role in these outcomes, evaluation of risk versus benefit is crucial in this patient population.<\/jats:p>","DOI":"10.22374\/1710-6222.25.1.5","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T12:59:36Z","timestamp":1526389176000},"page":"e53-e56","source":"Crossref","is-referenced-by-count":11,"title":["PREGNANCY OUTCOMES AFTER EXPOSURE TO TNF-\u03b1 INHIBITORS FOR THE TREATMENT OF ARTHRITIC DISEASES: A META-ANALYSIS OF OBSERVATIONAL STUDIES"],"prefix":"10.15586","volume":"25","author":[{"given":"Kamelia","family":"Mirdamadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Vali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manny","family":"Papadimitropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheline","family":"Piquette-Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","published-online":{"date-parts":[[2018,4,10]]},"container-title":["Journal of Population Therapeutics and Clinical Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/jptcp.com\/index.php\/jptcp\/article\/download\/31\/26","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jptcp.com\/index.php\/jptcp\/article\/download\/31\/26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:59:25Z","timestamp":1634345965000},"score":1,"resource":{"primary":{"URL":"https:\/\/jptcp.com\/index.php\/jptcp\/article\/view\/31"}},"subtitle":["TNF-\u03b1 Inhibitors and Pregnancy Outcomes in Arthritic Diseases"],"short-title":[],"issued":{"date-parts":[[2018,4,10]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,17]]}},"URL":"https:\/\/doi.org\/10.22374\/1710-6222.25.1.5","relation":{},"ISSN":["1710-6222","1198-581X"],"issn-type":[{"value":"1710-6222","type":"electronic"},{"value":"1198-581X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4,10]]}}}