{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T17:31:15Z","timestamp":1706031075113},"reference-count":0,"publisher":"Codon Publications","issue":"2","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Popl Ther Clin Pharmacol"],"abstract":"<jats:p>Objectives&#x0D;\nTo study the clinical profile and outcome in patients with epilepsy who developed psychogenic non-epileptic&#x0D;\nseizures (PNES) associated with levetiracetam (LEV) use.&#x0D;\nMethods&#x0D;\nIn this prospective observational study, conducted over 1 year, 13 patients with epilepsy and PNES, documented by video electroencephalogram (VEEG) while on LEV, were included. Those with past history of psychiatric illnesses were excluded. VEEG, high-resolution magnetic resonance imaging, neuropsychological and psychiatric evaluation were performed. Patients in Group I (07) were treated with psychotherapy, psychiatric medications and immediate withdrawal of LEV while, those in Group II (06) received psychotherapy, anxiolytics and LEV for initial 2 months after which it was stopped. Follow-up period was six months.&#x0D;\nResults&#x0D;\nMean (\u00b1SD) age of patients was 25 \u00b1 12.28 years; there were 11 (84.62%) females. All were on antiepileptic&#x0D;\nagents which included LEV &gt;1000 mg\/day, except one. Mean dose of LEV was 1269.23 \u00b1 483.71 mg\/day.&#x0D;\nThree patient\u2019s scores were suggestive of depression or anxiety; one had both depression and anxiety. Eight&#x0D;\npatients had mood disorders; three had a history of emotional abuse or neglect. PNES subsided in all&#x0D;\npatients within 1\u20133 months, only after withdrawal of LEV and did not recur in any after stopping LEV.&#x0D;\n&#x0D;\nConclusion&#x0D;\nLEV can induce PNES in susceptible populations. Awareness of this association is crucial for timely withdrawal of triggering factor and appropriate management. This will reduce inadvertent additional prescription\u00a0of antiepileptic agents.&#x0D;\n&#x0D;\n<\/jats:p>","DOI":"10.22374\/1710-6222.25.2.1","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T15:22:05Z","timestamp":1540826525000},"page":"e1-e11","source":"Crossref","is-referenced-by-count":5,"title":["LEVETIRACETAM-ASSOCIATED PSYCHOGENIC NON-EPILEPTIC SEIZURES: A HIDDEN PARADOX"],"prefix":"10.15586","volume":"25","author":[{"given":"Shaik Afshan","family":"Jabeen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padmaja","family":"Gaddamanugu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajith","family":"Cherian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kandadai Rukmini","family":"Mridula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dasari Uday","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angamuttu kanikannan","family":"Meena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6228","published-online":{"date-parts":[[2018,7,11]]},"container-title":["Journal of Population Therapeutics and Clinical Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/jptcp.com\/index.php\/jptcp\/article\/download\/46\/27","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jptcp.com\/index.php\/jptcp\/article\/download\/46\/27","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:59:19Z","timestamp":1634345959000},"score":1,"resource":{"primary":{"URL":"https:\/\/jptcp.com\/index.php\/jptcp\/article\/view\/46"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,7,24]]}},"URL":"https:\/\/doi.org\/10.22374\/1710-6222.25.2.1","relation":{},"ISSN":["1710-6222","1198-581X"],"issn-type":[{"value":"1710-6222","type":"electronic"},{"value":"1198-581X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,11]]}}}