{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:18:29Z","timestamp":1773944309226,"version":"3.50.1"},"reference-count":0,"publisher":"Undersea and Hyperbaric Medical Society (UHMS)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["UHM"],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:p>Background: Rheumatoid arthritis is a debilitating and destructive disease for which limited therapeutic\u00a0options exist.  Objective: This report summarizes serial magnetic resonance imaging (MRI) findings from nine study\u00a0participants treated with hyperbaric oxygen (HBO2) therapy and expands upon an earlier pilot study\u00a0that showed improvement in disease activity and joint pain as determined by multiple, validated\u00a0clinical measures.  Methods: Rheumatoid arthritis patients received 30 hyperbaric oxygen treatments over six to 10 weeks.\u00a0MRI with and without contrast was completed at baseline, and at three- and six-month intervals\u00a0following initiation of HBO2 therapy. Ratings were based on Outcome Measures in Rheumatology\u00a0Clinical Trials (OMERACT) Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) criteria,\u00a0the standard method for quantification of inflammation and damage by MRI in RA trials.  Results: Using RAMRIS criteria, nine of nine patients demonstrated no radiologic progression of\u00a0erosions, synovitis, or bone marrow edema at three- and six-month scans.  Conclusion: Our findings suggest that HBO2 therapy may be useful as an adjunctive or alternative\u00a0treatment to disease-modifying drugs for rheumatoid arthritis.<\/jats:p>","DOI":"10.22462\/01.01.2023.19","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T18:58:28Z","timestamp":1676919508000},"page":"39-43","source":"Crossref","is-referenced-by-count":3,"title":["The effects of hyperbaric oxygen on MRI findings in rheumatoid arthritis: A pilot study"],"prefix":"10.22462","author":[{"name":"David Grant USAF Medical Center, Travis AFB, California US","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Dulberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Slade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"David Grant USAF Medical Center, Travis AFB, California US","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"David Grant USAF Medical Center, Travis AFB, California US","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoinette","family":"McNeary-Garvin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"David Grant USAF Medical Center, Travis AFB, California US","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"David Grant USAF Medical Center, Travis AFB, California US","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance","family":"Edmonds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"David Grant USAF Medical Center, Travis AFB, California US","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9754","published-online":{"date-parts":[[2023,1,1]]},"container-title":["Undersea and Hyperbaric Medicine"],"original-title":[],"deposited":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T18:58:29Z","timestamp":1676919509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.uhms.org\/uhm-search\/uhm-journal-volume-50-2023\/number-1\/the-effects-of-hyperbaric-oxygen-on-mri-findings-in-rheumatoid-arthritis-a-pilot-study.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.22462\/01.01.2023.19","relation":{},"ISSN":["1066-2936"],"issn-type":[{"value":"1066-2936","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1,1]]}}}